1JR2,3D8N


Conserved Protein Domain Family
HemD
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cd06578: HemD 
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Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in the human uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria, a recessive inborn error of metabolism also known as Gunther disease.
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Statistics
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PSSM-Id: 119440
Aligned: 415 rows
Threshold Bit Score: -1
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:3D8N; Thermus thermophilus Uroporphyrinogen III synthase with bound product uroporphyrinogen III, contacts defined at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #                                                                    ###    
1JR2_A        24 VLLLKdakedd---cgqdpYIRELGLYGLEATLIPvlsfef--------lslpsFSEKLshp--edYGGLIFTSPRAVEA 90  human
3D8N_A        36 IAYAGlrr--------keeFKALAEKLGFTPLLFPvqatekv-----pvpeyrdQVRELaq----gVDLFLATTGVGVRD 98  Thermus thermop...
ZP_01916582    5 LVVCKpklpdqyltqrvdlKRQLDQMHSGHVMYFPvfelvpd------laslltIRPWLetttdkpNHLIVFVSPSVLEI 78  Limnobacter sp....
NP_299087     61 LLSLRpann-------haaLRRAVARYGGGLIALSpwrlkrl-----dspetrsALASAl-----tASTLVFTSPEAVRA 123 Xylella fastidi...
NP_635593     21 LLSLRpsge-------hapLRRAVARHGGQLLAVSpwrlqin-----dtlqardALRQAl-----gAPIVVFTSPAAVHA 83  Xanthomonas cam...
YP_002026519  22 FISLRpqgq-------haaLRRAVAGLDGHLLALSpwrlqrl-----hgtpvvrQLQRAl-----nCDRVVFTSPAAVAA 84  Stenotrophomona...
YP_001281152   3 FINTRpier-------aqpLTQAMQDKGLTVLELPlleltaieigqreqqyqqhFYQQPd-----qYQALVVVSPTAARM 70  Psychrobacter s...
YP_263398     27 VINTRpver-------aapLTRHLQAAGMSVIDMPmltlqprs---ttdndmilMRQWLag----eYQALVIVSPTAAAS 92  Psychrobacter a...
ABO10738       3 FINTRpdsr-------aaeLTHALQKKGFQVESLPllelvaqp----fseslsqLYQQLt-----gAQAIVVVSPTAVDV 66  Acinetobacter b...
AAS73063       3 IIDTRs-------------NIAFSNHKKGSIKNIPlfelk----------sfeyALPSKd------FTDIIFQSIPSVEF 53  uncultured mari...
3D8N_A        36 IAYAGlrr--------keeFKALAEKLGFTPLLFPvqatekv-----pvpeyrdQVRELaq----gVDLFLATTGVGVRD 98  Thermus thermop...
ZP_01916582    5 LVVCKpklpdqyltqrvdlKRQLDQMHSGHVMYFPvfelvpd------laslltIRPWLetttdkpNHLIVFVSPSVLEI 78  Limnobacter sp....
NP_299087     61 LLSLRpann-------haaLRRAVARYGGGLIALSpwrlkrl-----dspetrsALASAl-----tASTLVFTSPEAVRA 123 Xylella fastidi...
NP_635593     21 LLSLRpsge-------hapLRRAVARHGGQLLAVSpwrlqin-----dtlqardALRQAl-----gAPIVVFTSPAAVHA 83  Xanthomonas cam...
YP_002026519  22 FISLRpqgq-------haaLRRAVAGLDGHLLALSpwrlqrl-----hgtpvvrQLQRAl-----nCDRVVFTSPAAVAA 84  Stenotrophomona...
YP_001281152   3 FINTRpier-------aqpLTQAMQDKGLTVLELPlleltaieigqreqqyqqhFYQQPd-----qYQALVVVSPTAARM 70  Psychrobacter s...
YP_263398     27 VINTRpver-------aapLTRHLQAAGMSVIDMPmltlqprs---ttdndmilMRQWLag----eYQALVIVSPTAAAS 92  Psychrobacter a...
ABO10738       3 FINTRpdsr-------aaeLTHALQKKGFQVESLPllelvaqp----fseslsqLYQQLt-----gAQAIVVVSPTAVDV 66  Acinetobacter b...
AAS73063       3 IIDTRs-------------NIAFSNHKKGSIKNIPlfelk----------sfeyALPSKd------FTDIIFQSIPSVEF 53  uncultured mari...

Feature 1                                                   #                                    
1JR2_A        91 AElcleqnnktev-----------werslkekwnaKSVYVVGnATASLVSKIGLdtege---------tcgnAEKLAEYi 150 human
3D8N_A        99 LLeagkalgl-----------------dlegplakAFRLARGaKAARALKEAGLpphav---------gdgtSKSLLPLl 152 Thermus thermop...
ZP_01916582   79 AVtnlgq------------------------wpanVYCGVMGrQSAKLAIDLGIpkdniiaptgendhetedSDGLARLl 134 Limnobacter sp....
NP_299087    124 AHalqtl-----------------------raspgQVWLCVGaSTARMLQQCGItrvlh--------ptqmnSEGLLTLl 172 Xylella fastidi...
NP_635593     84 AHrllpl-----------------------qrpgpAQWASVGeGTARALQACGIdavvr--------parmdSEGLLALp 132 Xanthomonas cam...
YP_002026519  85 AAsllpl-----------------------adaqrSPWLTVGeGTARALRAQGVhevha--------pqrmdSEGLLALp 133 Stenotrophomona...
YP_001281152  71 GLaacpi-----------------------gfvprCAVIAVGhATAEVLRVAGWqvhcp---------veysNEGMMLMp 118 Psychrobacter s...
YP_263398     93 GLaiwqllererqangatdkavegiedslgvlvapSHLIAVGeATAAVLNEVKLpfasyqv----lqpaianNEGMLSMp 168 Psychrobacter a...
ABO10738      67 GMqyltqsgl------------------kidelkyIQWIAVGqATANRLHDYGIeahvp---------evetSEGMLNLp 119 Acinetobacter b...
AAS73063      54 FKekdh--------------------------linKDIYTMGpSTKNFLLQKGFdsicp---------aipgSKELIKLl 98  uncultured mari...
3D8N_A        99 LLeagkalgl-----------------dlegplakAFRLARGaKAARALKEAGLpphav---------gdgtSKSLLPLl 152 Thermus thermop...
ZP_01916582   79 AVtnlgq------------------------wpanVYCGVMGrQSAKLAIDLGIpkdniiaptgendhetedSDGLARLl 134 Limnobacter sp....
NP_299087    124 AHalqtl-----------------------raspgQVWLCVGaSTARMLQQCGItrvlh--------ptqmnSEGLLTLl 172 Xylella fastidi...
NP_635593     84 AHrllpl-----------------------qrpgpAQWASVGeGTARALQACGIdavvr--------parmdSEGLLALp 132 Xanthomonas cam...
YP_002026519  85 AAsllpl-----------------------adaqrSPWLTVGeGTARALRAQGVhevha--------pqrmdSEGLLALp 133 Stenotrophomona...
YP_001281152  71 GLaacpi-----------------------gfvprCAVIAVGhATAEVLRVAGWqvhcp---------veysNEGMMLMp 118 Psychrobacter s...
YP_263398     93 GLaiwqllererqangatdkavegiedslgvlvapSHLIAVGeATAAVLNEVKLpfasyqv----lqpaianNEGMLSMp 168 Psychrobacter a...
ABO10738      67 GMqyltqsgl------------------kidelkyIQWIAVGqATANRLHDYGIeahvp---------evetSEGMLNLp 119 Acinetobacter b...
AAS73063      54 FKekdh--------------------------linKDIYTMGpSTKNFLLQKGFdsicp---------aipgSKELIKLl 98  uncultured mari...

Feature 1                         #                       # #                                    
1JR2_A       151 csr---essaLPLLFPCGnlkreiLPKALKdkGIAMESITVYQTVAhp------giQGNLNSYYsqqg------------ 209 human
3D8N_A       153 pq------grGVAALQLYgkplplLENALAerGYRVLPLMPYRHLPdp------egILRLEEAVlrge------------ 208 Thermus thermop...
ZP_01916582  135 athf--eagsCRVMVCKGprgrveFPKKLVemQHDVTVLECYDRKVieqs--dtqcEALFARTSea-------------- 196 Limnobacter sp....
NP_299087    173 aqqp--ptevGLITAPGGrd---lLQQKLLenGIRLHRANVYERQPlrlr---tatLDVLQRNAtr-------------- 230 Xylella fastidi...
NP_635593    133 vfda-plhavGLITAPGGrg---tLSPALEqrGAQILRADVYQRVAlrlr---astLHALESALpr-------------- 191 Xanthomonas cam...
YP_002026519 134 vla---dvrgRRIGLVTApggrglIAAQLQaaGASIERADVYQRRPlrl-----spRTLARLAHsay------------- 192 Stenotrophomona...
YP_001281152 119 qlnrlgvgnrILVWRGRGgr--rvLVNFLQenGVGVDAIAWYQRQCpp------qaEHDFKQLLpqlglsevaklpdain 190 Psychrobacter s...
YP_263398    169 eidslqagdkLLVWRGLGgr--rlLVDTLQarGVHIDSIAWYERKIpvda--maqyQQWLQDFDsqnaiggit------- 237 Psychrobacter a...
ABO10738     120 llhrmqksgsVAFWRGEGgr--qfMMETLQqqGIQILNFVLYRRQCpqasystfkhLTQNSNYNldk------------- 184 Acinetobacter b...
AAS73063      99 pn-----lnnNKYLIVKGddglsdIFDYLYknKNNVEEISCYKRVKfk-------sYDDVKESFlka------------- 153 uncultured mari...
3D8N_A       153 pq------grGVAALQLYgkplplLENALAerGYRVLPLMPYRHLPdp------egILRLEEAVlrge------------ 208 Thermus thermop...
ZP_01916582  135 athf--eagsCRVMVCKGprgrveFPKKLVemQHDVTVLECYDRKVieqs--dtqcEALFARTSea-------------- 196 Limnobacter sp....
NP_299087    173 aqqp--ptevGLITAPGGrd---lLQQKLLenGIRLHRANVYERQPlrlr---tatLDVLQRNAtr-------------- 230 Xylella fastidi...
NP_635593    133 vfda-plhavGLITAPGGrg---tLSPALEqrGAQILRADVYQRVAlrlr---astLHALESALpr-------------- 191 Xanthomonas cam...
YP_002026519 134 vla---dvrgRRIGLVTApggrglIAAQLQaaGASIERADVYQRRPlrl-----spRTLARLAHsay------------- 192 Stenotrophomona...
YP_001281152 119 qlnrlgvgnrILVWRGRGgr--rvLVNFLQenGVGVDAIAWYQRQCpp------qaEHDFKQLLpqlglsevaklpdain 190 Psychrobacter s...
YP_263398    169 eidslqagdkLLVWRGLGgr--rlLVDTLQarGVHIDSIAWYERKIpvda--maqyQQWLQDFDsqnaiggit------- 237 Psychrobacter a...
ABO10738     120 llhrmqksgsVAFWRGEGgr--qfMMETLQqqGIQILNFVLYRRQCpqasystfkhLTQNSNYNldk------------- 184 Acinetobacter b...
AAS73063      99 pn-----lnnNKYLIVKGddglsdIFDYLYknKNNVEEISCYKRVKfk-------sYDDVKESFlka------------- 153 uncultured mari...

Feature 1                                #####                                                   
1JR2_A       210 -----------------vpasITFFSPSGLTYSLKhiqels---------------gdnidQIKFAAIGPTTARALAa-- 255 human
3D8N_A       209 ------------------vdaLAFVAAIQVEFLFEgakdpka------------lrealntRVKALAVGRVTADALRe-- 256 Thermus thermop...
ZP_01916582  197 --------------------vLWITSSETIEALDSqlarkses-----------rlktlkeTATVLTTHPRITAKCRe-- 243 Limnobacter sp....
NP_299087    231 -------------------smLALSSAEALALLLPqwpdnl---------------rrilyQRPVIATSKRLEDLACa-- 274 Xylella fastidi...
NP_635593    192 -------------------svMALSSSEALTLIVQqlppsl---------------atalkTRPVVASSDRMLEAARa-- 235 Xanthomonas cam...
YP_002026519 193 ------------------pwvLAVSSGEALQHFWRqlphal--------------qqrlqaHASVVVASDRLREQAQa-- 238 Stenotrophomona...
YP_001281152 191 lnslhispldnpdanskhkplVLISSGEAFTNWRLlmasideisd-------kavpnyqlnDFNYLTFGKRLTDTLNq-- 261 Psychrobacter s...
YP_263398    238 -------------isqqakpiVIVSSGTAFEHWQSivqatktlnlaaenqamsvnvtlelsDFAYVVLGERLANMVAe-- 302 Psychrobacter a...
ABO10738     185 -------------------wlVLITSEASWKYWLElclkn-----------------kaqpDCVYLVLGPRLFQLVKdyr 228 Acinetobacter b...
AAS73063     154 -------------------daVIFSSTFGAQIFFEeiys-------------------sdvKAKLFGISNRIINYISd-- 193 uncultured mari...
3D8N_A       209 ------------------vdaLAFVAAIQVEFLFEgakdpka------------lrealntRVKALAVGRVTADALRe-- 256 Thermus thermop...
ZP_01916582  197 --------------------vLWITSSETIEALDSqlarkses-----------rlktlkeTATVLTTHPRITAKCRe-- 243 Limnobacter sp....
NP_299087    231 -------------------smLALSSAEALALLLPqwpdnl---------------rrilyQRPVIATSKRLEDLACa-- 274 Xylella fastidi...
NP_635593    192 -------------------svMALSSSEALTLIVQqlppsl---------------atalkTRPVVASSDRMLEAARa-- 235 Xanthomonas cam...
YP_002026519 193 ------------------pwvLAVSSGEALQHFWRqlphal--------------qqrlqaHASVVVASDRLREQAQa-- 238 Stenotrophomona...
YP_001281152 191 lnslhispldnpdanskhkplVLISSGEAFTNWRLlmasideisd-------kavpnyqlnDFNYLTFGKRLTDTLNq-- 261 Psychrobacter s...
YP_263398    238 -------------isqqakpiVIVSSGTAFEHWQSivqatktlnlaaenqamsvnvtlelsDFAYVVLGERLANMVAe-- 302 Psychrobacter a...
ABO10738     185 -------------------wlVLITSEASWKYWLElclkn-----------------kaqpDCVYLVLGPRLFQLVKdyr 228 Acinetobacter b...
AAS73063     154 -------------------daVIFSSTFGAQIFFEeiys-------------------sdvKAKLFGISNRIINYISd-- 193 uncultured mari...

Feature 1                                   
1JR2_A       256 ----qGLPVSCTAEsp--tpQALATGI 276 human
3D8N_A       257 ----wGVKPFYVDEte--rlGSLLQGF 277 Thermus thermophilus HB27
ZP_01916582  244 ----lGYAHVVQIAtgiqsvNSWLKSN 266 Limnobacter sp. MED105
NP_299087    275 ----rGFISVYRTTgp--lpRQLAATA 295 Xylella fastidiosa 9a5c
NP_635593    236 ----aGFVQVHRSEgp--lpAQLAAAA 256 Xanthomonas campestris pv. campestris str. ATCC 33913
YP_002026519 239 ----lGLQRISRSAgp--agAQLVSAA 259 Stenotrophomonas maltophilia R551-3
YP_001281152 262 ----lQLNCVRIENld---tSEVWRGV 281 Psychrobacter sp. PRwf-1
YP_263398    303 ----qHLSYWRVEDla---pETILAAI 322 Psychrobacter arcticus 273-4
ABO10738     229 dqqqaHFHIIQLENls---pSGMIHHI 252 Acinetobacter baumannii ATCC 17978
AAS73063     194 ----iGYESKFIDYf----aNDIAESI 212 uncultured marine gamma proteobacterium EBAC20E09
3D8N_A       257 ----wGVKPFYVDEte--rlGSLLQGF 277 Thermus thermophilus HB27
ZP_01916582  244 ----lGYAHVVQIAtgiqsvNSWLKSN 266 Limnobacter sp. MED105
NP_299087    275 ----rGFISVYRTTgp--lpRQLAATA 295 Xylella fastidiosa 9a5c
NP_635593    236 ----aGFVQVHRSEgp--lpAQLAAAA 256 Xanthomonas campestris pv. campestris str. ATCC 33913
YP_002026519 239 ----lGLQRISRSAgp--agAQLVSAA 259 Stenotrophomonas maltophilia R551-3
YP_001281152 262 ----lQLNCVRIENld---tSEVWRGV 281 Psychrobacter sp. PRwf-1
YP_263398    303 ----qHLSYWRVEDla---pETILAAI 322 Psychrobacter arcticus 273-4
ABO10738     229 dqqqaHFHIIQLENls---pSGMIHHI 252 Acinetobacter baumannii ATCC 17978
AAS73063     194 ----iGYESKFIDYf----aNDIAESI 212 uncultured marine gamma proteobacterium EBAC20E09

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