1RP5


Conserved Protein Domain Family
PASTA_Pbp2x-like_1

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cd06576: PASTA_Pbp2x-like_1 
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PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are connected to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
Statistics
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PSSM-Id: 119327
View PSSM: cd06576
Aligned: 70 rows
Threshold Bit Score: 49.4298
Threshold Setting Gi: 81631121
Created: 3-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RP5_A      589 PMPSVKDISPGDLAEELRRnlVQPIVVGTGTkIKNSSAEEGKNLApNQQVLILSD 643 Streptococcus pneumoniae
YP_806494   603 TIPAVTNAALTTAQDSLKQanFDVATVGTGNkVVQQLPTSGTKALhGSRVLLLTN 657 Lactobacillus casei ATCC 334
Q71XX4      603 KVPVLAGKTIDEAKKIVKDkgLELIIVGNGKkIVQQLPQANAEIMqGQKVILMTD 657 Listeria monocytogenes str. 4b F2365
YP_395359   579 KVASVLSQSTKDAQKKLEAqnLKTTLVGSGNlVVQQLPKAGSVILpNQRVLLMTN 633 Lactobacillus sakei subsp. sakei 23K
ZP_01189226 572 VVPDIIGKKAIKAEEVLRKagLDVKLVGMKEkVLRQVPLPGARVKeGTTVIIFTE 626 Halothermothrix orenii H 168
ZP_02848477 585 SIPELAKLKVTEAKSQLRSrgLNAEIVGSGKtIIQQIPASGALVHpGQKVYLITE 639 Paenibacillus sp. JDR-2
AAN87416    589 AVPQVTGIGVDDAEDRLLHvgLGVATEGFGTrVVNQLPQPGEKVTpQTTVVLYLA 643 Heliobacillus mobilis
Q8R9G1      559 MVPDVRNMKLYEAERIILEnkLDFILQGNGDtVFDQVPKPGALVNeNTKIILYLN 613 Thermoanaerobacter tengcongensis
ZP_01369891 592 TVPSVLGLTLAEAEKSLRQagFTVLTEGSGTvVQDQIPHGDSKVEeGSSVLLYLG 646 Desulfitobacterium hafniense DCB-2
ZP_02184970 609 KMPKVTGIAKEEALKSLEDtqLNVTVVGNGDtIVQQLPLPEETTIeNQRVVLMTN 663 Carnobacterium sp. AT7
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