1RP5


Conserved Protein Domain Family
PASTA_Pbp2x-like_2

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cd06575: PASTA_Pbp2x-like_2 
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PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are attached to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
Statistics
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PSSM-Id: 119326
View PSSM: cd06575
Aligned: 114 rows
Threshold Bit Score: 49.7582
Threshold Setting Gi: 168182385
Created: 3-Sep-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RP5_A       647 EVPDMYGWTKETAETFAKwlNIELEFEGSGs-tVQKQDVRANTAIkd-iKKIKLTLG 701 Streptococcus pneumoniae
YP_001308708 684 VMPDVRGYSKEDANTLLKklGIVPAFEGSGa--VSEQDISQGEVItk-gTTVKLTLS 737 Clostridium beijerinckii NCIMB 8052
Q97H83       671 IVPNLTGYSKKEAEETLKslGLDFKISGDGv--VESQSIDAGKQVnk-gTVLTLKLE 724 Clostridium acetobutylicum
ZP_02620786  676 VVPNLKGYSKEKAAELLKnlGIQVKFIGDGv--VLDQSIAPGKAVnrgkAIVVLTLK 730 Clostridium botulinum C str. Eklund
ZP_01189226  638 TVPDLTGMTVNEALDLLFelGLKMDYNGSKeslIITQDIEPGSRVpg-gTTIIVEVS 693 Halothermothrix orenii H 168
Q8XJ81       673 VVPDFRKLNKEEAEEILKylGLKGEFEGEGe--IKEQSISAGEIIks-gDKIKFKLE 726 Clostridium perfringens
Q8XMX4       673 IIPDFKNYSKESAEKLLNqlGLIGEFVGEGp-sVTKQSISPDEVVng-nSKITLTLG 727 Clostridium perfringens
ZP_02949308  695 SMPDIKGYSKESAYELLSklGITATFEGEGa--ARDQSISSGEIVpk-gTSVKITLE 748 Clostridium butyricum 5521
Q8XJ98       684 IVPDFNGLSMEKAKEILNkiGLKGTFAGEGv--IKEQSVVQGDVVks-gTSIEFKLD 737 Clostridium perfringens
ZP_02092128  733 EVPDVTGKSPDFARQMLSaaGLNCVVEGSGt--VQAQSAEPGSSVqr-gTIITLTCG 786 Faecalibacterium prausnitzii M21/2
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