Conserved Protein Domain Family
TM_PBP1_branched-chain-AA_like

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cd06574: TM_PBP1_branched-chain-AA_like 
Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of monosaccharides including ribose, galactose, and arabinose. These transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. This group includes Escherichia coli LivM and LivH, two TMs which heterodimerize to form the translocation pathway of the E. coli branched-chain AA LIV-1/LS transporter. This transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) and LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine. Included in this group are proteins from transport systems that contain a single TM which homodimerizes to generate the transmembrane pore; for example E. coli RbsC, AlsC, and MglC, the TMs of the high affinity ribose transporter, the D-allose transporter and the galactose transporter, respectively. The D-allose transporter may also to be involved in low affinity ribose transport.
Statistics
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PSSM-Id: 119320
View PSSM: cd06574
Aligned: 25 rows
Threshold Bit Score: 128.164
Threshold Setting Gi: 160940484
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
TM-ABC
Feature 1:TM-ABC transporter signature motif
Evidence:
  • Comment:a signature motif (the EAA motif) conserved in all TMs of ABC transporters.
  • Comment:a conserved hydrophilic segment, part of a loop which interacts with the cytoplasmic ATPase.
  • Citation:PMID 7934906

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
P0AEX7        19 GSTYALIAIGYTMVYgiIGMI----------------NFAHGEVYMIGSYvsfmiiaalmmmgidtGWLLVAAGFVGAIV 82  Escherichia col...
P22729       118 TMIYIILGLGLNVVVglSGLL----------------VLGYGGFYAIGAYtfalln----hyyglgFWTCLPIAGLMAAA 177 Escherichia col...
O83343        15 STPILITALGGLFSEr-SGVI----------------NIALEGLMMFGAFstatvtvlcepytiaaPWIALGVGMAVAAS 77  Treponema pallidum
NP_602696     24 ISRNLFLIMSLLIPIv-AGMG----------------LNFGIVLGAMGGQlalilitnwhimglqgIFLAMILSIPFSIL 86  Fusobacterium n...
Q9ZDG1        11 SLIMLPLILGMYISYriLKIT----------------DLTVDGTYVLGAAvfart-------ipfgLFHALIFAIIAGGI 67  Rickettsia prow...
YP_556326     18 GLTYALIAVAIMIPFriLNFS----------------DMTGEGAFPFGACvcakll-----migfnPVMALLGGALAGFV 76  Burkholderia xe...
YP_594793     13 GLILAIIAFGIMIPFrfLNFP----------------DLTAEGAYPLGGAvcaslm-----vanmpQILAMMAGIMAGGL 71  Lawsonia intrac...
ZP_02087829  105 GPVSFFMAILIATPFa-LIFGggyg---------wllNKIKGGEMMIATYv---------------GFSSVSFMCMMWLL 159 Clostridium bol...
YP_001559159 194 MLLLLRILLVLYFVFsaANVIlrkkkegksgyklsiiKISVTILLLLLTLipair------dflgtDRLLLLNAITIGCV 267 Clostridium phy...
ZP_02087830   52 LGRNAFLILSLLIPIm-AGMG----------------LNFGMTLGAMAGEiglifvadwqiwgipgIILAMIISIPISIL 114 Clostridium bol...
Feature 1                                                                                        
P0AEX7        83 IASAYGw-------SIERVAYRPV-------------RNSKRl----iALISAIGMSIFlqnyvsltegsrdvalpslfn 138 Escherichia col...
P22729       178 AGFLLGf-------PVLRLRGDYLaivtl----gfgeIVRILllnnteITGGPNGISQIpkptlfglefsrtareggwdt 246 Escherichia col...
O83343        78 VALFYAy-------LSVRLCSDQI-------------IAGTA------INLCATGMTVFfaqvifgqqgtqaysrglvkt 131 Treponema pallidum
NP_602696     87 LGYIGGv-------ILNRAKGKEMi------------TSMILg----yFINGAYQLVVLysmgkifpvkdktlllssgrg 143 Fusobacterium n...
Q9ZDG1        68 NGSIVSf-------MQRNKRINGL-------------IAGIL------ANFMLYSVNLQimqrpnisvlgmpt------- 114 Rickettsia prow...
YP_556326     77 AGVLTGy-------IHEKAKINTL-------------LCGIL------VLSMLYSVNIRvmgqpnsalfayssvf----- 125 Burkholderia xe...
YP_594793     72 LAVGTSq-------VALRLKVNSL-------------LAGII------LSTMAYSINLRimgkpnialfd---------- 115 Lawsonia intrac...
ZP_02087829  160 LPYSSPt-------MVWGLSGKGLrttislegfydkaLANFLq-----INIGKISIPTG--------------------- 206 Clostridium bol...
YP_001559159 268 LAILYVitkicsikLIQKHKELEVnk----------yLAMIIia---iIVYALTYIPVVfditms--------------- 319 Clostridium phy...
ZP_02087830  115 LGLFCGk-------MLNMAKGREMv------------TSYIIs----fFMNGLYQLVVLymmgsiipiihssiklprgyg 171 Clostridium bol...
Feature 1                                                                     ###################
P0AEX7       139 g--------qwvvghsenfsasittmqaviWIVTFLAMLALTIFIRYSRMGRACRACAEDlKMASLLGINTDRVIALTFV 210 Escherichia col...
P22729       247 ---------fsnffglkydpsdrviflylvALLLVVLSLFVINRLLRMPLGRAWEALREDeIACRSLGLSPRRIKLTAFT 317 Escherichia col...
O83343       132 s--------ygffsripvlgpmvfthtyptVYLGFVLVALAWYVLYRTPFGVHVRATGDQpYAVDGAGLSVFRLRSAAVV 203 Treponema pallidum
NP_602696    144 ikntvdltevaksidnaiplrifrydipvlTILFIIALCFFVIWFRKTKLGQDMRAVGQDmEVSKSAGIEVNKVRIYAIV 223 Fusobacterium n...
Q9ZDG1       115 -----------------llsildldnwlvpLILINSFIIVIVLILLKGNLGLFLRAFGFNkDLLIDLGKPAELYRMLGLS 177 Rickettsia prow...
YP_556326    126 --------------swlpeagggylprilmLTVIDAVIGAGVLWFLGTQHGLAMRAIGSSpSMAKAQGINVKVYTLVGLG 191 Burkholderia xe...
YP_594793    116 --------------------mdgihfdfisLIIVGMFCIVPFALFLHTDFGLRFRTVGSNpKFAINHKISINKYTSLGLF 175 Lawsonia intrac...
ZP_02087829  207 ------------------------------SLLFFAFLAFLMWAFLHTKTGTAMTAVGSNpNFARASGINIDKTRMLSVI 256 Clostridium bol...
YP_001559159 320 ------------------------islpvcTYAAIILICGFNRWLLSTKLGQNMRTVGQSrTVANSAGINVNKTRIIAMC 375 Clostridium phy...
ZP_02087830  172 vrntvsllhmrqyldnllaihiggvkipvlTLIIIALLCLFIIWFRKTKLGQDMRAVGQDmDVAGDAGIKVERTRIIAII 251 Clostridium bol...
Feature 1                                                                                        
P0AEX7       211 IGAAMAAVAGVLLGQFYGvi-npYIGFMa-GMKAFTAAVLGGIg------------SIPGAMIGGLILGIAEAl------ 270 Escherichia col...
P22729       318 ISAAFAGFAGTLFAARQGfvspeSFTFAe-SAFVLAIVVLGGMg------------SQFAVILAAILLVVSREl------ 378 Escherichia col...
O83343       204 ISGLCAGLGGGVLILTQDiqytvYSTHGt-GFIALAALISGRW-------------HPFGVLVTSVLFGFSQIl------ 263 Treponema pallidum
NP_602696    224 ISTVLAGIGQVIYLQNLGtintyNSHEQi-GMFSVAALLIGGAsvara----tipnAISGVILFHTMFVVAPRag----- 293 Fusobacterium n...
Q9ZDG1       178 ISNGLAALTGTLSAQVNGfa-diNMGYGv-ALVGIGAIIIGRQiflnninnfnalkEIFACFIGILFYFISLSi------ 249 Rickettsia prow...
YP_556326    192 LANLFAALGGAMLAQNQGfa-dvNMGFGv-LVNGLAALLLGEAvvgnr----smlrQVLAPILGSIIYFQLISi------ 259 Burkholderia xe...
YP_594793    176 IAGSMFGLAGSLMVQMQQfm-diGMGVGi-VIHGLASLMIGESivgns----tipkQLAAPIIGSLIYQQIQGv------ 243 Lawsonia intrac...
ZP_02087829  257 MSTWLAAVGILMYEQGFGfi-qlYMAPFymALPAVSAILIGGAsvn--------kaSITNVIIGTFLFQGIVTmt----- 322 Clostridium bol...
YP_001559159 376 ISTVLASWGQLIYLQNLGtfstyGAHSMv-GLYAIAALLVGGAgvqma----nnkqAILGVILFHTLFVVAPLsa----- 445 Clostridium phy...
ZP_02087830  252 MSTVFAGLGMVIYLQNMGnistySSHTQi-GMFCIAALLVGGAsvdra----signVFLGVILFHLMFIVAPKagatitg 326 Clostridium bol...
Feature 1                                         
P0AEX7       271 --SSAYlst--------eyKDVVSFa-LLILVL 292 Escherichia coli K12
P22729       379 --MRDFne----------ySMLMLGg-LMVLMM 398 Escherichia coli K12
O83343       264 --NVYAtsvellkhlpielFSALPYa-LTVVVL 293 Treponema pallidum
NP_602696    294 keLMGSaqig------eyfRVFISYg-IIALVL 319 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
Q9ZDG1       250 --LLHIgid-------pinLKLILGi-VLFISL 272 Rickettsia prowazekii
YP_556326    260 --VLAVgfq-------psdLKLVTA--LFVLVT 281 Burkholderia xenovorans LB400
YP_594793    244 --ALSLgla-------psdLKFFTGsiVLIVLA 267 Lawsonia intracellularis PHE/MN1-00
ZP_02087829  323 ptVMNSmihmd---mseviRIVVSNg-MILYAL 351 Clostridium bolteae ATCC BAA-613
YP_001559159 446 snLLGSslig------eyfRVFICYg-VIALSL 471 Clostridium phytofermentans ISDg
ZP_02087830  327 dsMIGEy-----------fRVFISYg-VITVAL 347 Clostridium bolteae ATCC BAA-613

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