1C7T


Conserved Protein Domain Family
GH20_Sm-chitobiase-like

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cd06569: GH20_Sm-chitobiase-like 
Click on image for an interactive view with Cn3D
The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.
Statistics
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PSSM-Id: 119337
View PSSM: cd06569
Aligned: 20 rows
Threshold Bit Score: 676.703
Threshold Setting Gi: 5881581
Created: 22-Aug-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1C7T_A; Serratia marcescens chitobiase binds Di- N Acetyl-D-Glucosamine, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #                                                                
1C7T_A        307 DAPRFPYRGIFLDVARNFHKKDAVLRLLDQMAAYKLNKFHFHLSDDEGWRIEIPGLPELTEVGGQRCHDLsettCLLPQY 386  Serratia marc...
BAA84281      352 DAPRFEYRGMMLDVSRNFQSKETVFKLLDLMAFYKLNKFEINLANDEGWRLEIPGIPELTEFGAKRGYDLsestMLHTFM 431  Alteromonas s...
BAA92145      300 DAPRFAYRGVHLDVGRNFSSKESVLRLLDCMALYKLNQFHFHLTDDEGWRVEIPSLPELTEIGSGRGFTItetdNLVPCF 379  Aeromonas sp....
BAB17855      336 DSPRFSWRGMHYDNARNYHGKDALFKLIEQMARYKLNKFHWHFSDDEGWRLEIPGLPELTEVGAFRCFDLqereCLLTQL 415  Alteromonas s...
YP_444514     341 DAPRFDHRGLHLDVARNMQSVAAVKRLLDIMAFYKLNTFHFHLTDDEGWRLAVEGLPELTRVGGRRGHTLdeqaHLMPSY 420  Salinibacter ...
ZP_01460692   358 DAPGFVYRGMHLDVGRHFQSKETVKKLLDVISHFKINKFNIHLTDDEGWRLETPGIPELTSYGARRGFDLaeaeMLHAGL 437  Stigmatella a...
ZP_01886296   310 DAPRFGHRAFLLDIARNFQSKDEVYKIIDLMALYKMNVLHLHLNDDEGWRIEIDGLPELTSIGSRRGHSIan-dMLPPSY 388  Pedobacter sp...
YP_435910     348 DAPRFSYRGMHLDVARHFSQPESVKKLIDVMALYKLNKLHLHLSDDEGWRLEIPGLPELTSVGGKRGHSEneldNLVPSF 427  Hahella cheju...
XP_001637561  330 DAPRFEYRGMEIDLGRNFMPKSEILKLIDATSMYKLNKLHLHLTDDEGWRLEIPGLPELTTLGSKRCHDPkehdCIDSQL 409  starlet sea a...
ZP_02434136   287 DYPDFSYRGHMQDVARNFIELSDLKKLIDILSSYKLNVFRFHFSDDEGWRLQIPGLEELTEIASHRGHTYneseCLYPAY 366  Bacteroides s...
Feature 1                                                                                    #    
1C7T_A        387 Gqgp-------------------------------------dvyGGFFSRQDYIDIIKYAQARQIEVIPEIDMPAHARAA 429  Serratia marc...
BAA84281      432 GaangfapgdgienkptdetaanlgtapsyqgfeiaqqnflgkgWGYYTVNDFKEILQYAADRHIDVIIEYDFPAHARAA 511  Alteromonas s...
BAA92145      380 Gsgaev---------------------------------egshgTGFYTRAEFVEILKFATARHIEVVPEFDVPGHARSA 426  Aeromonas sp....
BAB17855      416 Gtgpfk----------------------------------tgsgNGYLSREDFVELLKFATARHIEIIPEIESPGHARAA 461  Alteromonas s...
YP_444514     421 Gsgpsps-------------------------------peasrgSGWYSRADYLDILRYAKARHITVMPEIDVPGHARAA 469  Salinibacter ...
ZP_01460692   438 GsgsdlqdgdlirlkpatpqkanaetppayqgfetatlnfvgkgSGYYTTKDFEEILKYATERHIEVIPEIDVPGHARAA 517  Stigmatella a...
ZP_01886296   389 Gsgpgt---------------------------------dnpfgTGYFSRKEYIALLKYAAARYVDIIPEIETPGHARAA 435  Pedobacter sp...
YP_435910     428 Gsgpfa---------------------------------dsnngSGYFSRRQYIELLRYAAERHIEVVPEFDLPGHARAA 474  Hahella cheju...
XP_001637561  410 Gsgpgt----------------------------------gnsgTGYYTVSEYRDILRYARDRHVEVIPEFDMPGHGHAA 455  starlet sea a...
ZP_02434136   367 Ngdfdyq--------------------------------sktsgNGFYSRDEFIDLLRYAADRHVAIIPEIESPGHARAA 414  Bacteroides s...
Feature 1                                             ##                                          
1C7T_A        430 VVSMEARYKKLhaagkeqeaneFRLVDQTDTSNTTSVQFFnrqsyLNPCLDSSQRFVDKVIGEIAQMHkea-gqpIKTWH 508  Serratia marc...
BAA84281      512 IKAMEHRYNKYkdsdp-veanrFRLIDPLDQSQYYTPQFYtd-nfVNPALESTFTFLNHVVRETRAIYdavpdatLTRLH 589  Alteromonas s...
BAA92145      427 IKAMNVRYDRLvkagqqaeaekYLLVDFDDKSKYESVQLWtd-nvICIAREGAYNFIETVIHDVKDMYaea-gapWTTMH 504  Aeromonas sp....
BAB17855      462 IKSMEARYHKLmeagkaqeakaYLLNDIDDTSKYLTVQLYtd-nsINVCLDSSYAFMEKVVYELQEMYrda-gtmLTTVH 539  Alteromonas s...
YP_444514     470 IQAMEARTRRLraagdtaaaraYRLRDPADTSDYESVQGWdd-nvMNVCRPSTYRFLSTVVDELRGLHeaa-gapLPAVH 547  Salinibacter ...
ZP_01460692   518 VKAMEYRYRKLkdldp-aqaaaYRLIDPNDTSKHKSVQGYtd-nfINPCLDTSYAFLTKVAEEIKARYaaa-gapLKTIH 594  Stigmatella a...
ZP_01886296   436 IKSMDARYDYYmkkgkkqeaeeFLLRDRADSSVYRSVQGWnd-nvINPALPSTYQFIRKVTGELVRMYaea-gapLKTIH 513  Pedobacter sp...
YP_435910     475 IKSMEARAKHFaeagkpyqgrnFLLSDPEDKSEYKSVQGWkd-nvINPCMPTTYFFIDKVVGEVSRMYrqa-glrMPAFH 552  Hahella cheju...
XP_001637561  456 IKAMQSRYRKYlamgdkykanqYILSDPLDKSEYLSVQFFtd-naINPCLESTYEFIEHIVFQVRRMHfdv--qpLKTFH 532  starlet sea a...
ZP_02434136   415 IVAMKARYKKYqdtdp-ikaheYLLHDIHDTSQYVSAQGYsd-nvMNVAMPSTYRFMKKVIQEIQLMYkea-gvpLRSIH 491  Bacteroides s...
Feature 1            ##                                                                           
1C7T_A        509 FGGDDAknirlgagytdkakpepgkgiidqsnedkpwaksqvcqtmikegkvadmEHLPSYFGQEVSKLVKAhgidRMQA 588  Serratia marc...
BAA84281      590 GGGDELphlgpnewwaqsp-----------------------avdqnpatagktdAELFDYFFLRWKQIVNQhg-fDMAT 645  Alteromonas s...
BAA92145      505 TGGDEVphgawegspicq--------------------------kfmkdnalesiQELQDHFLARYRDILKKyg-lTFGG 557  Aeromonas sp....
BAB17855      540 FGGDEVgkgswtespacnd------------------------lfavadngvagpNDLKPYFTQKVAKLLAKrg-iTPAA 594  Alteromonas s...
YP_444514     548 VGGDEVpegawagspicd-------------------------dyiartegvdgaDDLFGHFLGRFQDTLATrg-iAMAG 601  Salinibacter ...
ZP_01460692   595 AGGDELpalnpnvwwqgsp-----------------------lckanpatkdmddHQLFNHFFTRWNQIIKAtg-aEMTG 650  Stigmatella a...
ZP_01886296   514 MGGDEVpegvwakspavl-------------------------qllekepsigsvYGMWKYYFSKVNDILKTqh-lYLSG 567  Pedobacter sp...
YP_435910     553 VGADEVpagvwkkspactr------------------------mfgseelsadevETLNRFFNATVTGIVAAhg-tKIAG 607  Hahella cheju...
XP_001637561  533 FGGDEVahgawtkspacaal---------------------aqklglnftspsivKDLKEYFVRRVSKITSKyc-lDLGS 590  starlet sea a...
ZP_02434136   492 IGGDEVaegawkgspick--------------------------nfmlehnmtdvQELSDYFIMRIVDFLKEqn-iPFSG 544  Bacteroides s...
Feature 1         #                                   #                                           
1C7T_A        589 WQDglkdaess-------------kafatsrVGVNFWDtlywg------------------gfdsVNDWANKGYEVVVSN 637  Serratia marc...
BAA84281      646 WGDvlshngtgn----------vsygeiypvFWNNVWGwgn---------------------ehqAYKFANQGHKVVLAH 694  Alteromonas s...
BAA92145      558 WEEialkketvegvthhgpnpkfvdanfrpyIWNNVWGwgq---------------------edfAYQLANAGYKVVLCN 616  Aeromonas sp....
BAB17855      595 WEDglmynttttf---------krdefpnpqFLVNTWDniwew-----------------gvadrAHRFANNNYQVILSH 648  Alteromonas s...
YP_444514     602 WEEvgleeadhrsattt-pnealvdddvqpyVWSNIWGggt---------------------edrAYRLANAGYDVVMAQ 659  Salinibacter ...
ZP_01460692   651 WDDiihnglt--------------lpgfipmPWSNVWGwgr---------------------eddAYKYANQGYQVILSH 695  Stigmatella a...
ZP_01886296   568 WEEiglkktlvngkg----kwitdptvsgrgYTTDVWNniigt-----------------gaedlAYKLANGGFKVVLSN 626  Pedobacter sp...
YP_435910     608 WEElafmhedggkvv----nphfvggimipyVWNNVWGwgt---------------------ednAYKLANAGYPVVLAN 662  Hahella cheju...
XP_001637561  591 WEDgvlgvkdkpydr-----gylpnrnvyayAWDNVWEwghgsrayklanagykashffragidkTFSSINVAAQVVMTQ 665  starlet sea a...
ZP_02434136   545 WQEiaaghdkdf-----------drylsenaLGISCWKasphs-----------------hsdelVYQFANKGYPVILCN 596  Bacteroides s...
Feature 1             # ##          # #                                                           
1C7T_A        638 PdyVYMDFPYEvnPDERGYYWgtrfsdERKVFSFAPDnmpqnaetsvdrdg--------nhfnaksdkpwpgAYGLSAQL 709  Serratia marc...
BAA84281      695 AtnLYLDLAYNkhPDEIGYHWagy-tdTKKAFEYRPFniyanaerdklgnpvp----wdpkwvllseagkqnVQGIQAQL 769  Alteromonas s...
BAA92145      617 VtnLYFDLAYEkdPKEPGYYWggf-inTRKAYEFVPLdiyttatvnlfghdlg---dslkdkarltpegtknVIGIQGEL 692  Aeromonas sp....
BAB17855      649 GthLYFDHPYEahPEERGYYWatrytdTKKAFSYMPDniyanadftrnrepivn-lealvgrelpalkrpqnILGMQGQI 727  Alteromonas s...
YP_444514     660 AtnFYFDMAYSkhPREDGYYWagf-vdTKAPFAFVPFdlyksadrtrmghpidp-dtafadqvrladtarnnIRGLQGQL 737  Salinibacter ...
ZP_01460692   696 StnLYMDLAYNkdPDEPGYYWanf-vdEKKTFEYRPFdiyanathdrmgnaikp--edlaskvrltaegkknILGMHGLL 772  Stigmatella a...
ZP_01886296   627 VtnNYLDMAYNnsFYEHGMNWagf-vnVDKPFYFIPYnyylttteneygepvaq--sffrnkdqlkaesknnIIGLQSAL 703  Pedobacter sp...
YP_435910     663 AtnLYFDLAYQkaPEEPGYYWagf-vdTRRVYEFTPMdvfkaawvdrmgnpltd--dmwndrtrlaadkqdmILGVQGEL 739  Hahella cheju...
XP_001637561  666 AthLYFDHPYEpdPEERGYYWapryidTRKTFGFMPDnlyanadftrmgdpivdlcqtmykgqcvplkepnnIAGMAGAL 745  starlet sea a...
ZP_02434136   597 AsnFYFDLAYDkhPNEPGHNWngy-vdESKSFSLLPYsiyrsirnrqvek----------ektrlteqgrknIKGVESAL 665  Bacteroides s...
Feature 1         # #                                                                             
1C7T_A        710 WSEtqrtdPQMEYMIFPRALSVAERSWHragweqdyragreyk-------------------------ggethfvdtqal 764  Serratia marc...
BAA84281      770 FGEnqkspEILDYMTFPKLLGAAERAWVqdmpaq------------------------------------------gaat 807  Alteromonas s...
BAA92145      693 WGEnlrdaGRLEYLAMPRIVALAERAWAkdpgwtqiad----------------------------------ktardakm 738  Aeromonas sp....
BAB17855      728 WSEtirseDQVLRLIFPRLLSLAERAWHkadwegrr--------------------------------------inqkel 769  Alteromonas s...
YP_444514     738 WGEtlrkpDRMEYMAVPRLLSLAERAWAprpgwatldd----------------------------------sgalrarr 783  Salinibacter ...
ZP_01460692   773 WGEnlktpEVVEYLAFPKVLGVAERAWNpelpev-------------------------------------------sam 809  Stigmatella a...
ZP_01886296   704 WSEtlvaeGLLEYMVLPKLLGSAERSWAkdpawsgtqg----------------------------------aifssqey 749  Pedobacter sp...
YP_435910     740 WSEnvkteSDLFYLALPKLLGLAERAWSpqpdwanead----------------------------------qaqrlsgl 785  Hahella cheju...
XP_001637561  746 WSEtvrtpSQLQSMIYPRLLALAERAWHkacweiesdv-----------------------------------tersrlq 790  starlet sea a...
ZP_02434136   666 WSEtirnfEQVEYYLFPKIMGLSERGWHaspqwenitgiheqytyekdlsfyyqrisqkeipywekmevnyrlpfpglyi 745  Bacteroides s...
Feature 1                    
1C7T_A        765 ekDWLRFANIL 775  Serratia marcescens
BAA84281      808 teAWHTFTNTL 818  Alteromonas sp. O-7
BAA92145      739 daDWNQFANRL 749  Aeromonas sp. 10S-24
BAB17855      770 nkDFSTFAAAL 780  Alteromonas sp. O-7
YP_444514     784 aeAWTAFANRL 794  Salinibacter ruber DSM 13855
ZP_01460692   810 paLWGQFTNSL 820  Stigmatella aurantiaca DW4/3-1
ZP_01886296   750 kqAWSTFTSTI 760  Pedobacter sp. BAL39
YP_435910     786 nqAWSGFAARV 796  Hahella chejuensis KCTC 2396
XP_001637561  791 vmDWEMFANAL 801  starlet sea anemone
ZP_02434136   746 dnDGILFANSS 756  Bacteroides stercoris ATCC 43183

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