1OY0,1M3U,1O66


Conserved Protein Domain Family
KPHMT-like

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cd06557: KPHMT-like 
Click on image for an interactive view with Cn3D
Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a precursor to coenzyme A and is required for penicillin biosynthesis.
Statistics
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PSSM-Id: 119342
View PSSM: cd06557
Aligned: 180 rows
Threshold Bit Score: 284.697
Threshold Setting Gi: 85704649
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         #                  # ###                                     # 
1OY0_A        23 THHLQRWKadgHKWAMLTAYDYSTARIFDEaGIPVLLVGDSAANVVYGYDTTVPISIDELIPLVRGVVRGapHALVVADL 102 Mycobacterium t...
1M3U_A         6 ISLLQKYKqekKRFATITAYDYSFAKLFADeGLNVMLVGDSLGMTVQGHDSTLPVTVADIAYHTAAVRRGapNCLLLADL 85  Escherichia coli
ZP_01035751    9 LKHLAEKVqkgERIVGMECHDTPSAMMAEElGMDLLCCGSPGPMGLMGHKSMATVDFEEQLYMLQGVLRGasSPFIICNM 88  Roseovarius sp....
YP_001019980  16 ITEIRDSKksgEKMVYTSVPDYTSAKWAELaGVDVAVVGDSLAMVAHGHSSTVPATMDMMVMHAQAVRRGapRTFTLGCM 95  Methylibium pet...
ZP_01816173    5 PSSFVEMKg-kQRIPMLTAYTFPVAASIESaGIPIILVGDTVGMVEMGFSSTRDVTIEHMEYHVGAVRRGapNTHIIGDL 83  Vibrionales bac...
YP_001319056   7 ILDLMKMKkaeEQVAWVTAYDFPTASFAEQaGMEMILVGDSLGMVVLGYQGTIPVTMEDCISHCQAVRRGapNTWVIGDM 86  Alkaliphilus me...
YP_001528968   4 LSVFRDYKkqgRKITMLTAYDYPTAVLEDRaGIDILLVGDSVGRNILGYASELEVTMEDMLHHVRAVARGakQAHVMGDM 83  Desulfococcus o...
ZP_02125029   25 ITDIRNSKrtgEKMVYMSVPDYTSARWAEMaGVDVAVVGDSLAMVAHGHPSTIPATMDMMVLHAQAVRRGtpNTFVLGCM 104 Methylobacteriu...
ZP_02947175    4 SARFFEMKrrgEPIAVLTAYDAPTARAEAEaGVDVILVGDSVGANVLGYASEREVTLADMRHHVAAARRGapDAVIIGDL 83  Methylocella si...
YP_001834345   7 AARFAEMKrrgEPIAMLTAYDAPMARAEAAaRVDILLVGDSVGTNMLGYASEQEVTLADMAHHTRAVRRGapDAFVISDL 86  Beijerinckia in...
Feature 1                                    #                       #    #                      
1OY0_A       103 PFGSYeagptAALAAATRFLKdGGAHAVKLEGGerVAEQIACLTAAGIPVMAHIGFTPQSVNTLGgfrvqg-rgdaaEQT 181 Mycobacterium t...
1M3U_A        86 PFMAYat-peQAFENAATVMR-AGANMVKIEGGewLVETVQMLTERAVPVCGHLGLTPQSVNIFGgykvqgrgdeagDQL 163 Escherichia coli
ZP_01035751   89 PNTTAsisieESVRNAAKVVK-LGADGVHIEPSlgTVPHIRAIVDAGIPVVGHFGVQGERAVMNSghspagrtageaAAI 167 Roseovarius sp....
YP_001019980  96 PYQSYnt-vdRALLNATRFMQdGGCDAVKPQGGrsQAHILKALVDSGIPTASHIGLTPHTIAMFGgfkiqgrtaeaaMKI 174 Methylibium pet...
ZP_01816173   84 PYLTDrs-peAALFNAKRLMQ-AGADSIKLEGA--KLDVIAHLVANNIPVVGHTGLTPQTATNFKkvgqs---aedaQTV 156 Vibrionales bac...
YP_001319056  87 PFGSYqvsdeDAVRNAVRFMKeADVDCIKLEGGdrVKSRIRAITDAGIPVMGHIGLTPQSSGQLGgfkaqgrrvdnaRVL 166 Alkaliphilus me...
YP_001528968  84 PYRSCdt-paLALENARRMMD-AGAHSVKIEGEqdMVDRIKYVVDAGVPVCAHIGYTPQTSGKAAvqgkd---idraKAL 158 Desulfococcus o...
ZP_02125029  105 PYQSYnt-veRALTNATRFMQdALCDAVKPQGGrsQAHILKALVDAGIPTASHIGLTPHTIATFGgfkiqgrtaeaaMKI 183 Methylobacteriu...
ZP_02947175   84 PFETYgg-peIAIASARALIG-AGADIVKFEGA--DVAVLKALTDAGIEVCCHLGLEPQTHADKRlkgrs---aqdaARL 156 Methylocella si...
YP_001834345  87 PVATYet-ptEAVANARVLAE-AGADMVKFEGC--RPAIVEALVGAGFAVCGHLGLEPQHHAEKRlkgkq---ageaHQL 159 Beijerinckia in...
Feature 1                         #                              # #                             
1OY0_A       182 IADAIAVAEAGAFAVVMEMVPAELATQITGKltIPTVGIGAGpnCDGQVLVWQDMAGfsgaktarFVKRYAdvGGELRRA 261 Mycobacterium t...
1M3U_A       164 LSDALALEAAGAQLLVLECVPVELAKRITEAlaIPVIGIGAGnvTDGQILVMHDAFGitgghipkFAKNFLaeTGDIRAA 243 Escherichia coli
ZP_01035751  168 IELVRASIEAGIFAALFEHTSVELTKWCYENlpVAVASLGSGpyAHGIFHVSSDIIGcsvfpippKRELFGdvWGEMQKA 247 Roseovarius sp....
YP_001019980 175 LEDAFAIQDAGCFMLEFEAVPAKIATLISKQleIPTIGIGAGagCDGQILLSYDLLGvftdfkpkFTKRYAnlTEVAVQG 254 Methylibium pet...
ZP_01816173  157 SEEAKAIQEAGAFMLVLEHIPSSLGESITKEisIPTIGIGAGadCDGQVLVINDALGlgnr-wppFSKQYAhcSQTIFDA 235 Vibrionales bac...
YP_001319056 167 IQDALVVQEAGAFSLLVEAVPPEVTKFIADKldIPVYSIGAGp-CDGQLVISGDMLGkfqaftpkFIKKYAnvAEVETNA 245 Alkaliphilus me...
YP_001528968 159 IDAALQLEKAGADMVVFELIPELLAKEITNLlsIPTIGIGAGrfCDGQVQVYCDILGlsar-vfrHAKAYDtlGQRYEDA 237 Desulfococcus o...
ZP_02125029  184 LEDALAIEDAGCFMLEFEAVPAPIAKLISEQlsIPTIGIGAGagCDGQILLAYDLLGvfidfkpkFTKRYAnlTEVAVTG 263 Methylobacteriu...
ZP_02947175  157 LADAIRLDEAGMKMLVLEMIPEEVAAEITRAvrAPTIGIGAGrrTDGQVLVITDVLGfgar-nfrHNRRYQevGRLMRET 235 Methylocella si...
YP_001834345 160 VEAALTMEKAGIAMLVLELIPEEVAEIVTQRlkVPTIGIGAGraTDGQVLVICDVLGytka-afrHNKRYAevGETMEAA 238 Beijerinckia in...
Feature 1                      
1OY0_A       262 AMQYAQEVAGGVFP 275 Mycobacterium tuberculosis
1M3U_A       244 VRQYMAEVESGVYP 257 Escherichia coli
ZP_01035751  248 YSAYYNAAKSGQFP 261 Roseovarius sp. 217
YP_001019980 255 LKAYVDEVKTGRFP 268 Methylibium petroleiphilum PM1
ZP_01816173  236 ANEFATQVKTNVFP 249 Vibrionales bacterium SWAT-3
YP_001319056 246 FKEYVAEVKAGQFP 259 Alkaliphilus metalliredigens QYMF
YP_001528968 238 FAAYAREVTGGTFP 251 Desulfococcus oleovorans Hxd3
ZP_02125029  264 IRSYVEEVKTGAFP 277 Methylobacterium nodulans ORS 2060
ZP_02947175  236 AAAYVRDVHDGGFP 249 Methylocella silvestris BL2
YP_001834345 239 ARAYVGDVHSKAFP 252 Beijerinckia indica subsp. indica ATCC 9039

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