1WK2


Conserved Protein Domain Family
ASCH_ASC-1_like

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cd06554: ASCH_ASC-1_like 
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ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation. The domain has been named after the ASC-1 protein, the activating signal cointegrator 1 or thyroid hormone receptor interactor protein 4 (TRIP4). ASC-1 is conserved in many eukaryotes and has been suggested to participate in a protein complex that interacts with RNA. It has been shown that ASC-1 mediates the interaction between various transciption factors and the basal transcriptional machinery.
Statistics
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PSSM-Id: 119346
View PSSM: cd06554
Aligned: 31 rows
Threshold Bit Score: 81.9935
Threshold Setting Gi: 168724474
Created: 12-Aug-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1WK2_A         5 KLGLIVREPYASLIVDGRKVWEIRRRk---TRHRGPLGIVSg--gRLIGQADLVGVEGPFsv--------eELLAHQek- 70  Thermus thermop...
BAA31049       1 MKGLIIKQPYANWIVEGKKVWEIRKTp---TKIRGRVIIISe--kKAVGSVEIVDVLGPFtp--------eELANHEnkh 67  Pyrococcus hori...
ZP_02756751    1 MKCLIVKEKWADLILSGEKTLELRSRn---TNVRGTIGIIKsgtgLICGTVDILSSYEITdee------yiELKNKHk-- 69  Clostridium dif...
ACD38834       1 MKALSIRQPWAWLVANGHKDIENRDWa---TNFRGRFLVHAs---KGMTREEYEEARDYAarngvtipaphELERGGivg 74  Pseudomonas aer...
YP_001582852   1 MKCLSVSQPFAELIILGKKTIELRKWn---TNYRGELLIHSp---LKIRKEDAKRLKIDK-----------KFVTGAivg 63  Nitrosopumilus ...
ZP_02066917    1 MKAITIKQPWASLIVHGIKDIENRTWacpwKYIGHRVLIHAs--gKPVEMRNPNSVFTKAqw--------dSLPIEFqrk 70  Bacteroides ova...
YP_002026022   1 MKALSIRQPWAWLVAAGHKDIENRTWp---TSYRGPLLIHAs---KGMTRAEYENAMRFAivagiaykelqCFDESArgg 74  Burkholderia ps...
YP_565156     61 IRVLAIRQPWASLIIRGLKNIEVRSKn---TYVRGTIAIYAs--rSIIRKKDLKLVNENYdipi---eqldDLPTGMiig 132 Methanococcoide...
ZP_02011132   22 LPALAIRQPYAWLVINGIKDIENRSRr---THYRGKVLIHA----SLSEDLLFEDSLAELgir-----agiELPESYdig 89  Opitutaceae bac...
ZP_01852580   12 LPALGIRQPWAELILRGEKTIEIRSSq---TKIRGTIYVYAs--kKLATTPHAVKAASKAgid------vnTLPTGTlv- 79  Planctomyces ma...
1WK2_A        71 ------------------hLAEEAFLRAYAkd-----------epLYAWVLENAFRY 98  Thermus thermophilus
BAA31049      68 -----------------laSYDFLKRYANGk-------------kLYAWVLANPEKY 94  Pyrococcus horikoshii OT3
ZP_02756751   70 -------------------VPYSREQIKYKk--------------IFAWELHNPVKY 93  Clostridium difficile QCD-76w55
ACD38834      75 k--------------asiiGCVYDSDSPWFf-------------gKYGFELSDARPL 104 Pseudomonas aeruginosa
YP_001582852  64 kveiy-------dvkkydsQKQVKSDQKFHfaskn------fhdrTYGFLLKNAKTF 107 Nitrosopumilus maritimus SCM1
ZP_02066917   71 iicaegivnsaiigsveiiGCSINHPSKWAektddsk--gyyenpIYNWVLANPILF 125 Bacteroides ovatus ATCC 8483
YP_002026022  75 i---------------igiADLFDCVPPSRavspw------qiegSYGFALRNARPL 110 Burkholderia pseudomallei Pasteur 52237
YP_565156    133 tvnlvec--keyesdfhfkLDQRRHLNPEEsys----------knIKGWFLKSPRPI 177 Methanococcoides burtonii DSM 6242
ZP_02011132   90 giv----------gvaeivGCERRHESDWKdp------------sSWGWVLANARPL 124 Opitutaceae bacterium TAV2
ZP_01852580   80 -----------------gtVEIVDSFPATEkhaaaagvpaellagKYGWKLANPRRL 119 Planctomyces maris DSM 8797
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