1K30,1IUQ


Conserved Protein Domain Family
LPLAT
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cd06551: LPLAT 
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Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis.
Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).
Links
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Statistics
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PSSM-Id: 153244
Aligned: 29 rows
Threshold Bit Score: 76.6841
Created: 12-Dec-2003
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:putative acyl-acceptor binding pocket
Evidence:
  • Structure:1IUQ_A; Cucurbita moschata glycerol-3-phosphate acyltransferase binds glycerol and a sulfate ion in the putative glycerol-3-phosphate binding site, contacts at 5A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                    #  #  #                       ####  
1K30_A       110 GNSFVgnl--slfKDIEEKLqqg-------------hnVVLISNHQTEa-DPAIIslllektnpyiaentIFVAGDRVla 173 crookneck pumpkin
1IUQ_A       109 GNSFVgnl--slfKDIEEKLqqg-------------hnVVLISNHQTEa-DPAIIslllektnpyiaentIFVAGDRVla 172 crookneck pumpkin
P0ACV0       101 DRRIArwtevigmEHIRDVQaqk-------------rgILLVGIHFLTl-ELGARqfgm--------qepGIGVYRPNdn 158 Escherichia col...
AAK14816       8 IRWLCkvivksvfRDVNVINpenvp---------lygsVIFVGNHNNQfiDACVLiani--------prqVKFIVAEKsm 70  malaria parasit...
O15228       134 FSKVCvne--egiQKLQRAIqe--------------hpVVLLPSHRSYi-DFLMLsfllyn---ydlpvpVIAAGMDFlg 193 human
NP_593657    107 SRLLLlcf---gcLKLSKSTsgsfvqg-----dslqpgDILAVNHSSPl-DVLVLscl----------ynCTFAVCDSkt 167 fission yeast
EEH11733      69 WVMLGipg--iwwIDLQIDGvkkgslasqhssplpgpaSVIASSFTSPi-DALYLaai----------fdPIFTVSYPst 135 Ajellomyces cap...
Q9SHJ5       367 ANFLAsms--gvrITFKTHNlnngrp------ekgnsgVLYVCNHRTLl-DPVFLttslg-----kpltaVTYSLSKFs- 431 thale cress
XP_001765001 280 MWWALplea-mlgVTVRVKGipptcpl-----rnkkrgVLFVCSHRTLl-DPIFLsiavr-----rkvtaVTYSISRLs- 346 Physcomitrella ...
ABK25381     277 EKYVKisyk-imgIKLVVKGtpppapk-----kkgergVLFVCDHRTLl-DPVIVavalg-----rkvsaVTYSISRFs- 343 Sitka spruce

Feature 1                                                                                        
1K30_A       174 d-plcKPFSIgr---nLICVYskkhmfdipel------------------------------------------------ 201 crookneck pumpkin
1IUQ_A       173 d-plcKPFSIgr---nLICVYskkhxfdipel------------------------------------------------ 200 crookneck pumpkin
P0ACV0       159 p-lidWLQTWgrlrsnKSMLDr---------------------------------------------------------- 179 Escherichia col...
AAK14816      71 ---rrAVIGKlasvigCISVKrpqdlkfkgighicwnkgdvkitgintrfrldvqigdklliqnkmfpvvkiesetelli 147 malaria parasit...
O15228       194 mkmvgELLRMs----gAFFMRrtfggn----------------------------------------------------- 216 human
NP_593657    168 s--nvSIISAqa---yFWSCFfspskl----------------------------------------------------- 189 fission yeast
EEH11733     136 ----cKVQQIsl--vqAILRAfarpev----------------------------------------------------- 156 Ajellomyces cap...
Q9SHJ5       432 -----EFIAPl----kTVSLKrdr-------------------------------------------------------- 446 thale cress
XP_001765001 347 -----EVLSPi----rTVRLTrdr-------------------------------------------------------- 361 Physcomitrella ...
ABK25381     344 -----EIISPi----kTVRLTrdr-------------------------------------------------------- 358 Sitka spruce

Feature 1                                                         ###                            
1K30_A       202 -----------------tetkrkantrSLKEMALLLrgg-sqLIWIAPSGGRDrpdpstgewypaPFDASSVDNMRrliq 263 crookneck pumpkin
1IUQ_A       201 -----------------tetkrkantrSLKEXALLLrgg-sqLIWIAPSGGRDrpdpstgewypaPFDASSVDNXRrliq 262 crookneck pumpkin
P0ACV0       180 --------------------------kDLKGMIKALkk--geVVWYAPDHDYGprss-----vfvPLFAVEQAATTtgtw 226 Escherichia col...
AAK14816     148 qeviniecedkmngvpfkiipkinqteVYNLVTNSLkn--gdTIGIFPEGGSHdrt-------nlLPLKPGVAIMTlcal 218 malaria parasit...
O15228       217 ---------------------klywavFSEYVKTMLrng-yaPVEFFLEGTRSrsa-------ktLTPKFGLLNIVmepf 267 human
NP_593657    190 ---------------------kitdakPLAKVAAKAski-gtVVILFPEGVCTngr-------alCQFTPCFDSAKet-- 238 fission yeast
EEH11733     157 ---------------------kppagsRLVDIATLIkrhpnsPIVVFPECTTTngk-------giLQMSPSLVAVSaa-- 206 Ajellomyces cap...
Q9SHJ5       447 -------------------------kkDGEAMQRLLsk---gDLVVCPEGTTCrep-------ylLRFSPLFAELTe--- 488 thale cress
XP_001765001 362 -------------------------ntDANTMASLLee---gDLVVCPEGTTCrep-------ylLRFSSLFAELTd--- 403 Physcomitrella ...
ABK25381     359 -------------------------erDAANIKRLLee---gDLVICPEGTTCrep-------flLRFSALFAELTd--- 400 Sitka spruce

Feature 1                                                                                        
1K30_A       264 h--sdvpgHLFPLALLChdimpppsqvei---------------eigekrviafnGAGLSVApeisfeeiaathkn---- 322 crookneck pumpkin
1IUQ_A       263 h--sdvpgHLFPLALLChdixpppsqvei---------------eigekrviafnGAGLSVApeisfeeiaathkn---- 321 crookneck pumpkin
P0ACV0       227 mlarmsgaCLVPFVPRRkpdg-------------------------------kgyQLIMLPPecsppldda--------- 266 Escherichia col...
AAK14816     219 ad-giedvSIIPVGLSYskly------------------------------qlqgCATLFYGnaiiisqdlck------- 260 malaria parasit...
O15228       268 fkrevfdtYLVPISISYdkileetlyvyellgvpkpkesttgllkarkilsenfgSIHVYFGdp---------------- 331 human
NP_593657    239 -------dRIFPLYIKYlppcvtlpvpsll-------------sfarsvlltvsfEIRIRFSaepliprnctdvtesaqe 298 fission yeast
EEH11733     207 -------tRIFPVSLRYtpadittpipqsy------------rsfmwnllskpthCIRVRIAesvllptqtkstknnnih 267 Ajellomyces cap...
Q9SHJ5       489 --------DIVPVAVDArvsmfygtt---------------------asglkcldPIFFLMNprpvycleilkklpk--- 536 thale cress
XP_001765001 404 --------QIVPVTMNIkitmfhgts---------------------argwkgmdPFFFFMNpcpkyevtfldqlph--- 451 Physcomitrella ...
ABK25381     401 --------RIVPVAICNkmsmfhgtt---------------------vrgwkgfdPFFFFMNpvptyevtfldqlpt--- 448 Sitka spruce

Feature 1                                   
1K30_A       323 ------peevreayskalfdSVAMQYN 343 crookneck pumpkin
1IUQ_A       322 ------peevreayskalfdSVAXQYN 342 crookneck pumpkin
P0ACV0       267 -----------ettaawmnkVVEKCIM 282 Escherichia coli K12
AAK14816     261 ---------eynnnnreaisKLLSKIE 278 malaria parasite P. falciparum
O15228       332 -------------------vSLRSLAA 339 human
NP_593657    299 vlsklgrsrvvklgksdklsYLDARSK 325 fission yeast
EEH11733     268 ngsrlgptdgqpsydhnyfnALDARLA 294 Ajellomyces capsulatus G186AR
Q9SHJ5       537 -----emtcaggkssfevanFIQGELA 558 thale cress
XP_001765001 452 -----qltcnggktshevanYIQRVLA 473 Physcomitrella patens subsp. patens
ABK25381     449 -----eltcaggkspievanYIQRVLA 470 Sitka spruce

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