1L7V,1L7V,2QI9,2QI9,2NQ2,2NQ2


Conserved Protein Domain Family
TM_ABC_iron-siderophores_like

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cd06550: TM_ABC_iron-siderophores_like 
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Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.
Statistics
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PSSM-Id: 119348
View PSSM: cd06550
Aligned: 78 rows
Threshold Bit Score: 96.8572
Threshold Setting Gi: 14195338
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interfaceABC-ATPaseputative PBP
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:2NQ2_AB, Haemophilus influenza putative metal-chelate-type ABC transporter, interface between the two TMs (2NQ2_AB), defined at 3.5A contacts.
    View structure with Cn3D
  • Structure:1L7V_AB, Escherichia coli BtuCD transporter BtuC (2) homodimer interface, defined at 3.5A contacts.
    View structure with Cn3D
  • Structure:2QI9_AB, Escherichia coli BtuCD transporter, BtuC (2) homodimer interface,defined at 3.5A contacts.
    View structure with Cn3D
  • Comment:BtuCD (1L7V) is in an outward-facing conformation. In BtuCD (2QI9) complexed with the binding protein, BtuF, the central cavity is accessible to neither side of the membrane.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                            # #    #                                                 
1L7V_B     60 TLAVLLVGAALAISGavxQALFENPLAEPGLlGVSNGAGVGLIAavllgqgq---lpnwalglCAIAGALIITLILLrfa 136 Escherichia coli
2NQ2_A     66 ILTALCVGAGLALSGvvlQGIFRNPLVNPHIiGVTSGSAFGGTLaiffgfs------lyglftSTILFGFGTLALVFlfs 139 Haemophilus influe...
Q56954     14 MVKAIWVSAIVGAVCaflSAYLMLKGWSLMGdALSHSVVPGVAGayalgf-------pyaagaFFTGMLAALAMTLVrhi 86  Yersinia pestis
P44661     14 MLKAMILSTAVGGICaflSSYLMLKGWSLIGdALSHSVVPGVAIayafal-------pyalgaFFAGILAALSILWIksi 86  Haemophilus influe...
P31606     33 MQRAFVIGLIAALLAgivGSFLMLQRLTLLSdAISHSVLPGLAIafsfgi-------plifgaLLASIISVIIINWIrte 105 Cyanophora paradoxa
P42361     15 LQNALITAIVIGVVAgavGCFIILRGMSLMGdAISHAVLPGVALsfilgi-------nffigaITFGLLASIIITYIkgn 87  Streptococcus gord...
Q9KD29     17 LQQALTAAILVGIICgviGCFIILRGMALMGdAISHAVLPGVVIaymiga-------sffigaVITGVITALAIGYVsqn 89  Bacillus haloduran...
Q92AG0     13 LQKALITSVTVGIVSgviGSFIILRGMSLMGdAISHAVLPGVAIsymmgm-------nffigaATFGIAAALGIGFVnqk 85  Listeria innocua C...
Q9PKW9     37 DDIQVIVFFAIAVSCsiiGTFLVLKKMAMYAnVVSHTILFGLVCaclfthqlthlsmqnltiaAISTTLLTGASIHFirn 116 Chlamydia muridaru...
O84072     11 FLSSFLAVSLICMTTalwGTILLVERQPLLSeSLSHACYPGLLIgallsykvp--afsdslwvIIFFGCLASVLGCLgis 88  Chlamydia trachoma...
Feature 1              # ##  ##  ##  #  ## #             ##  #                                
1L7V_B    137 rr--hlstsRLLLAGVALGIICSALXTWAIyfsts--vdlrqLXYWXX-GGFGGVDWRQs-wLXLALIPVLLWICCQSRP 210 Escherichia coli
2NQ2_A    140 fkfnqrsllMLILIGMILSGLFSALVSLLQyisdte-eklpsIVFWLM-GSFATSNWEKllfFFVPFLLCSSILLSLSWR 217 Haemophilus influe...
Q56954     87 t-----rlrEDAIIGFIFSTFFAVGLLIVSlnpt-----svnVQSIIF-GNILGIADEDvlqVEIIILVSFVILCLIWKD 155 Yersinia pestis
P44661     87 s-----klkEDAVIGFIFSTFFALGLLIVSlnpt-----avnVQNIIL-GNILGIADEDiyqVAIIIGVCLVLLLLFWKD 155 Haemophilus influe...
P31606    106 s-----rlkEDTAIGIVFASFFGLGILLISviqke---nkvdLNHFLF-GNILGITSEDlqnTSIILAIILLFFISCYRQ 176 Cyanophora paradoxa
P42361     88 s-----iikSDTAIGITFSSFLALGIILISvaks-----stdLFHILF-GNILAVQDLDmwiSIGVGILVLLVISIFFKQ 156 Streptococcus gord...
Q9KD29     90 s-----rvkEDSAIGILFTAAFALGIVLITgmrg----tgvdLWHILF-GNVLAVSRTDlwvTLGIGLFVLLIIILFYRP 159 Bacillus haloduran...
Q92AG0     86 s-----rikNDTAIGIVFSAFFALGIILISfaks-----stdLYHILF-GNVLAVRSSDmwmTIIIAILVISLVAIFYKE 154 Listeria innocua C...
Q9PKW9    117 v----fkvaEEASTALVFSLLFSASLLLLVfltr-----nahVGTELViGNADALAKTDifpVFLVLLXNLGVSYCFFSS 187 Chlamydia muridaru...
O84072     89 flekklamhKDSALCLVLVSFFGVGVILVSyvkdccpllynkINAYLY-GQAATLGYTEaklALIIFCLSAVVLWWWYRQ 167 Chlamydia trachoma...
Feature 1                                                 #                                   
1L7V_B    211 XNXLALGEISARQLGlplWFWRNVLVAATGWXVGVSVALAGAIGF-IGLVIPHILRLCGltdHRVLLPgCALAGASALLL 289 Escherichia coli
2NQ2_A    218 LNLLSLDEKEAKALGvkmAPLRWLVIFLSGSLVACQVAISGSIGW-VGLIIPHLSRMLVganHQSLLPcTMLVGATYMLL 296 Haemophilus influe...
Q56954    156 LLAVFFDESHAMSIGlspLRLKILFFTLLSACTVAALQTVGAILViAMVVTPGATAYLLtdrFGRLLIiAIAIGAITSAF 235 Yersinia pestis
P44661    156 LLLIFFDETQAITVGlspLFYKILFFTLLSACVVAALQTVGAILViAMVVTPGATAYLLtdkFKTLSIiAIILGAVTSFV 235 Haemophilus influe...
P31606    177 LKCYTFDPIMAQTIGlpiNFLQSTFLILVALTIIVSMKAIGVILVlALLVTPGATGLLIgksLEYVILtSSIIGVSCSFS 256 Cyanophora paradoxa
P42361    157 LLLTSFDPLLAQAMGmkvNFYHYLLMILLTLVSVTAMQSVGTILIvAMLITPAATAYLYaksLKTMILlSSALGAGASVL 236 Streptococcus gord...
Q9KD29    160 LLLSTFDPVMAQATGipvQMIHYLLMLLLSLVTVAALQTVGIVLVvAMLITPGATAYLLtnrLPVMLClAAMFGVISAIA 239 Bacillus haloduran...
Q92AG0    155 FLVSSFDPVMAEAYGlnvRFLHYFLMLLLTLVTVSALQTVGIILVvAMLITPAATAYLLtnkLSKMIMlASTFGAVSAII 234 Listeria innocua C...
Q9PKW9    188 FICVSFDTVFAFSLGirvKLIDYLMMFLLSASIVGAFKAVGVLMSlAFLLVPGLIAKLIassVQEMMGySMIFGVLSALI 267 Chlamydia muridaru...
O84072    168 ISVAIFDREFAYSCGlrtRTAELVVLVFISLVIVSGVRSVGILLIsAMFVAPPLSARQLsdrLSTILIlSSIFGGICGAL 247 Chlamydia trachoma...
Feature 1                               #  ##  #  ##  #
1L7V_B    290 ADIVARlala---------aaeLPIGVVTATLGAPVFIWLL 321 Escherichia coli
2NQ2_A    297 VDNVARsls----------daeIPISILTALIGAPLFGVLV 327 Haemophilus influenzae
Q56954    236 GAYLSFyl-------------dGATGGVIVTLQTLVFLPAF 263 Yersinia pestis
P44661    236 GVYISYyl-------------dGATGGVIVTLQTLLFLVAF 263 Haemophilus influenzae
P31606    257 GMLLSYlf-------------nIPPGPTIVLITSLIFFILF 284 Cyanophora paradoxa
P42361    237 GLFIGYsf-------------nVAAGSSIVLTSALIFLVSF 264 Streptococcus gordonii str. Challis
Q9KD29    240 GIYFSViy-------------dVASGASIVLVASTLFALAF 267 Bacillus halodurans C-125
Q92AG0    235 GLYFSYif-------------nLASGAAMVLVATIIFFIAF 262 Listeria innocua Clip11262
Q9PKW9    268 APALSRsil-----------svHGIGLSTSGLAVCLLLVFY 297 Chlamydia muridarum Nigg
O84072    248 GCYFSVaftcqtvvegkpisiiLPTGPLVVFFAGVLVFLCL 288 Chlamydia trachomatis A/HAR-13

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