1NH6,1ITX,3B9A,1KFW,1LL4,1E6Z,1O6I,1UR9


Conserved Protein Domain Family
GH18_chitinase

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cd06548: GH18_chitinase 
Click on image for an interactive view with Cn3D
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
Statistics
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PSSM-Id: 119365
View PSSM: cd06548
Aligned: 71 rows
Threshold Bit Score: 286.834
Threshold Setting Gi: 189467212
Created: 4-Aug-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #                            #                                               
1NH6_A       137 VGSYFVEWGVYGRnftvdk-ipaqnLTHLLYGFIPICggngindslkeiegsfqalqrscqgredfkvsihdpfaalqka 215 Serratia marces...
AAG35111     123 NLAYFTNWGIYGRkyspld-vpycnLTHVLYAFADVNpdtgecfltdlwadeq-----------------------ihyt 178 Ustilago maydis
CAG77802       3 NVIYFCNWSIYARkhlpwe-ipcssTTHIIYAFANCDpltgevqlsdkwadeq----------------------ivfen 59  Yarrowia lipoly...
Q06350        75 SGVYYSNWSPYKPrfhfphdinlkqVSHIYYAFFKINsrtggientdswsdlemnlyks----------laiknselike 144 baker's yeast
XP_360159     49 SVAYVTNWSIYGAkflpeq-iavdsISHVQYAFADILangtvvssdawadtq------------------------kqfg 103 Magnaporthe gri...
EAU86796      64 NFAYFTNWGIYGAnfqptd-ivpdyITHILYSFADTDastgaikltdpysdeq-----------------------krfp 119 Coprinopsis cin...
CAG99140      68 VATYYSNWSPYNArnhkpadiptsqLTHVYYAFFVVDaksgavkssdsw------------------------------- 116 Kluyveromyces l...
XP_001804658  40 SQVFYTNWAMYGRkhfvtd-lpadhLTKINYGFANVNnktgevflsdewsdv------------------------qfpy 94  Phaeosphaeria n...
AAS51062      65 VGVYYSSWSPYKPrlhyprnidfqrVTHVYYAFFVVDektgkigsldkwsd--------------------------tkm 118 Ashbya gossypii...
AAP49451      58 SLGYYPNWGVYAKkyfvtd-ipadhFTHLSYAFANVNnktgevylsdpyadlq-----------------------yayp 113 uncultured Neot...
Feature 1                                                                                     # #
1NH6_A       216 qkgvtawddpyKGNFGQLMALKQAHPd--LKILPSIGGWTLs--dPFFFMg-dKVKRDRFVGSVKEFlqtwkfFDGVDID 290 Serratia marces...
AAG35111     179 gdswndtgnnlYGNFKQFLLLKKKNRa--LKLMLSVGGWTFg--pHFAPMaadAKKRAKFVSTAITIlen-dgLDGIDID 253 Ustilago maydis
CAG77802      60 dkwtddsekqlHGCFYQFNLLKRQHRq--LKLFLSIGGYSFa--gNFAEMakdETKRKRFAESAAQHvin-lgLDGIDLD 134 Yarrowia lipoly...
Q06350       145 ssnnsvqnilpLGCIGELFYLKNTCSdkkFKVIMSIGGWSDs--eNFKIIikdDKLLQNFVDSSVETmfr-lgFDGIDLD 221 baker's yeast
XP_360159    104 ngtqggnssdaHGLVEQLYKIKQANRn--VKMLLSIGGYTWs--pKFVPVaadAGKRAAFVSSAVALmgd-wgMDGLDVD 178 Magnaporthe gri...
EAU86796     120 gdtwtetgnnlYGCLKQLYLLKMKKRd--LKVLLSIGGWTYsqagHFNFVt-nPTARAKFISDAVQLied-ygFDGIDID 195 Coprinopsis cin...
CAG99140     117 sdfelplsvgvKGCIKELQKIKLESKh-eFKTILCLGGWSNr--eAYKKIaksEKKVKKFIETAVDCmfr-ygFDGIDLD 192 Kluyveromyces l...
XP_001804658  95 pgdvatngsqlLGNFNQLYKLKQKNRn--LKVILSVGGWTWr--gNFKPAlatEAGRQKFCDSSLQLiad-lgLDGFDID 169 Phaeosphaeria n...
AAS51062     119 pmnltgmprglNGAIGELNYLKTRPGt-dFKLMMAVGGWSNr--ePFHKIvrdEEKFNNFIDSAIDAmfe-ygFDGIDLD 194 Ashbya gossypii...
AAP49451     114 gddtkakgnnlYGNFKQLYKLKKENRy--LNTLLAIGGFTYs--aNFGPVlasKPLRETFAKSAVKLvad-lgLDGLDLD 188 uncultured Neot...
Feature 1         #                                                                              
1NH6_A       291 WLFPggkganpnlgspqDGETYVLLMKELRAMLdqlsve---------tgrkyELTSAISAGKDKIDKvaynVAQNSMDH 361 Serratia marces...
AAG35111     254 WEYPsd---------stQAANFVLLLKELRAGLtahqakk-------netnpyLLSIAAPCGPDHYKVlqvaKMDQYLDF 317 Ustilago maydis
CAG77802     135 WEYAdt---------deKAQQYVELLRAVRLELdsvalkt------gldrhtfGLSIAAPGSVWYAKHlkiaEMDQFLSF 199 Yarrowia lipoly...
Q06350       222 WEFPgnn--------esEPRGYLKLVRMLRLKLnslesqif----gkrtedhfQLSIAAPAFKDKLFYlpitEIDQYVDY 289 baker's yeast
XP_360159    179 WEYPdt---------aeTNKNCVLLLQELRRGLddysqqh------tgsqykfSLSMPAPAGPTHYAAfdfkAMDASLDF 243 Magnaporthe gri...
EAU86796     196 YEYPst---------peQGQGLADLVTSLRTALtqlasrk-------gesnpyLITAAVGAGPAGYSNlkvaQMDRAMDY 259 Coprinopsis cin...
CAG99140     193 WEFPeed--------snEPIVYLEMMRGIREGMdqlerqifgspaeekdhphfQLSVATPAFAEKLNIlpisEMSKYVDI 264 Kluyveromyces l...
XP_001804658 170 WEYAed---------atDAANFLDTVMRCRKAYdeyaaan-------ahgyhfDLGISAPAGPSRYSVlrmkEMDQYVDN 233 Phaeosphaeria n...
AAS51062     195 WEFPkdd--------gyEPQMYLEMCSRLRHKMdeledniwg--pggtteprfHLSMAAPAFPQTLGIfpveEMNKYLSM 264 Ashbya gossypii...
AAP49451     189 YEYVan---------skEAEEIVDLLRLLREGLdklnrds-------katapfLLTFASPAGEQRYKVlnfpEMSKYVDL 252 uncultured Neot...
Feature 1           # ##                                                                      #  
1NH6_A       362 IFLMSYDFYGafdlknLGHQTALNapawkp------------------dtaytTVNGVNALLAqGVKPGKIVVGTAMYGR 423 Serratia marces...
AAG35111     318 WNLMAYDFAGsws-alTGHQANLWnikg---------------------appsADDSINYYIGqGVVSHKLVLGIPLYGR 375 Ustilago maydis
CAG77802     200 WNIMAYDFAGsws-pqSGHQSNLYgge------------------------isVDQIMNYYVQnGVASEKLILGMPIYGR 254 Yarrowia lipoly...
Q06350       290 WNMMTYDYYGsws-etTGYHSNLFsete----------------------lngNFAMHYMIDRfGVNSRKLVLGMAAYGR 346 baker's yeast
XP_360159    244 WSIMAFDFAGswd-ntTGHQANVYpgpdl-------------------ttkasIDVAVSDYVKaGVAPGKINLGLPLYGR 303 Magnaporthe gri...
EAU86796     260 WNLMAYDYAGswl-twADNQANFYggar---------------------tgysTDAALKWYISqGATKSKINVGMPLYGR 317 Coprinopsis cin...
CAG99140     265 WNMMCYDFHGews-dvTGYHSNLYlqghshrrsls--------nrisnsslssDTAVKLMTDRhNISSRRIALGMAAYGR 335 Kluyveromyces l...
XP_001804658 234 WNLMAFDYQGggfsnfTGHQSNVYasktnpkttdgw------dsvlgkfmpfnTKEAIDYYKAnVASPCKIVLGMPLYGR 307 Phaeosphaeria n...
AAS51062     265 WNMMTYDYHGaws-erTGYHSNLYnatnspykshldkrryedmgidnfdelnaHDAILMMTEQfKVSPRKIALGMAAYGR 343 Ashbya gossypii...
AAP49451     253 YNFMAVDYAGpsfskkTGYLDNLYadkknpd----------------atpfntASGIHYYLHEgKVPGSKIVVQNPLYGS 316 uncultured Neot...
Feature 1                                                                                        
1NH6_A       424 GWTGvngyqnnipftgtatgpvkg--------twengivdyrqiasqfmsgeWQYTYDATAEAPYVFKpstgDLITFDDA 495 Serratia marces...
AAG35111     376 GFENtdgpqqpyrgtgqgt------------------weagnwdykflpvkgAKEMINTKIAASWSYDsakrEFISYDTP 437 Ustilago maydis
CAG77802     255 SFAGtdglnkpytsvgegtqee-------------gswergvwdykklprpgFEAHFDDQCKASYLYNkdtkTLVTYDDV 321 Yarrowia lipoly...
Q06350       347 SFHIkdnkfepfnqntvlinkifkgvgkptkeidkadgkegiwpyknlpkigTIEQYDPKYVSAYCFDeknsIFISYDNT 426 baker's yeast
XP_360159    304 SFDKttglgkgytastagsl----------------egqagiwiykdlpragATVLYDDVAKASYTMDnstgQLISYDDL 367 Magnaporthe gri...
EAU86796     318 AFQNtdglgapysgigpgt------------------iepgiysykalplagGQVYENKTDMTSYSYDpvkrELVSYDTP 379 Coprinopsis cin...
CAG99140     336 GFTNvetnddnylgkkyhgvgg------------gsegepgiwlynqlpidgSKEQFDSNAVSAYCFDpksrTFVGYDNV 403 Kluyveromyces l...
XP_001804658 308 SFGNvvdlskdqrglgqkfngsg-----------egtwepgtldykflplngSKVYQDKETLSSWSWDpvkkEVVSFDTP 376 Phaeosphaeria n...
AAS51062     344 GFTNvrgdgeqligqkysgvgg------------gsegepgmwlynqlplahGPEKFDNVWVSAYSYDpntkTLVVYDNV 411 Ashbya gossypii...
AAP49451     317 AFNGtngigqsfkdaglqgsl--------------gtagtwfvkdlppkgfnLEVTNNKAVGGSYSYDkaqkYLIAHDTP 382 uncultured Neot...
Feature 1                            #     
1NH6_A       496 RSVQAKGKYVLDKQLGGLFSWEIDAD 521 Serratia marcescens
AAG35111     438 QNVLLKCQYIRNKRLRGAMFWELSGD 463 Ustilago maydis
CAG77802     322 NVVKLKSEYVRQKNLGGGMWWESSAD 347 Yarrowia lipolytica CLIB99
Q06350       427 KSVKTKAEYVTHNNLGGGFWWESCGE 452 baker's yeast
XP_360159    368 KSVQFKSDYVKQKQIGGVMFWESSQD 393 Magnaporthe grisea 70-15
EAU86796     380 NIVRMKAIYVEKNGLGGTMFWELSTD 405 Coprinopsis cinerea okayama7#130
CAG99140     404 QSMDIKGKYIKKKNLNGGFWWESCGD 429 Kluyveromyces lactis NRRL Y-1140
XP_001804658 377 KTAVWKTDFLKSEGLGGAWWWDSSSD 402 Phaeosphaeria nodorum SN15
AAS51062     412 DSMKIKKEYVKDKKLAGAFLWESCGD 437 Ashbya gossypii ATCC 10895
AAP49451     383 VTVRQKVDYVKKTKLAGTSFWEISQD 408 uncultured Neotyphodium

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