1NH6,1ITX,3B9A,1KFW,1LL4,1E6Z,1O6I,1UR9


Conserved Protein Domain Family
GH18_chitinase
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cd06548: GH18_chitinase 
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The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.
Links
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Statistics
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PSSM-Id: 119365
Aligned: 71 rows
Threshold Bit Score: -1
Created: 4-Aug-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #                            #                                               
1NH6_A       137 VGSYFVEWGVYGRnftvdk-ipaqnLTHLLYGFIPICggngindslkeiegsfqalqrscqgredfkvsihdpfaalqka 215 Serratia marces...
AAG35111     123 NLAYFTNWGIYGRkyspld-vpycnLTHVLYAFADVNpdtgecfltdlwadeq-----------------------ihyt 178 Ustilago maydis
CAG77802       3 NVIYFCNWSIYARkhlpwe-ipcssTTHIIYAFANCDpltgevqlsdkwadeq----------------------ivfen 59  Yarrowia lipoly...
Q06350        75 SGVYYSNWSPYKPrfhfphdinlkqVSHIYYAFFKINsrtggientdswsdlemnlyks----------laiknselike 144 baker's yeast
XP_360159     49 SVAYVTNWSIYGAkflpeq-iavdsISHVQYAFADILangtvvssdawadtq------------------------kqfg 103 Magnaporthe gri...
EAU86796      64 NFAYFTNWGIYGAnfqptd-ivpdyITHILYSFADTDastgaikltdpysdeq-----------------------krfp 119 Coprinopsis cin...
CAG99140      68 VATYYSNWSPYNArnhkpadiptsqLTHVYYAFFVVDaksgavkssdsw------------------------------- 116 Kluyveromyces l...
XP_001804658  40 SQVFYTNWAMYGRkhfvtd-lpadhLTKINYGFANVNnktgevflsdewsdv------------------------qfpy 94  Phaeosphaeria n...
AAS51062      65 VGVYYSSWSPYKPrlhyprnidfqrVTHVYYAFFVVDektgkigsldkwsd--------------------------tkm 118 Ashbya gossypii...
AAP49451      58 SLGYYPNWGVYAKkyfvtd-ipadhFTHLSYAFANVNnktgevylsdpyadlq-----------------------yayp 113 uncultured Neot...
AAG35111     123 NLAYFTNWGIYGRkyspld-vpycnLTHVLYAFADVNpdtgecfltdlwadeq-----------------------ihyt 178 Ustilago maydis
CAG77802       3 NVIYFCNWSIYARkhlpwe-ipcssTTHIIYAFANCDpltgevqlsdkwadeq----------------------ivfen 59  Yarrowia lipoly...
Q06350        75 SGVYYSNWSPYKPrfhfphdinlkqVSHIYYAFFKINsrtggientdswsdlemnlyks----------laiknselike 144 baker's yeast
XP_360159     49 SVAYVTNWSIYGAkflpeq-iavdsISHVQYAFADILangtvvssdawadtq------------------------kqfg 103 Magnaporthe gri...
EAU86796      64 NFAYFTNWGIYGAnfqptd-ivpdyITHILYSFADTDastgaikltdpysdeq-----------------------krfp 119 Coprinopsis cin...
CAG99140      68 VATYYSNWSPYNArnhkpadiptsqLTHVYYAFFVVDaksgavkssdsw------------------------------- 116 Kluyveromyces l...
XP_001804658  40 SQVFYTNWAMYGRkhfvtd-lpadhLTKINYGFANVNnktgevflsdewsdv------------------------qfpy 94  Phaeosphaeria n...
AAS51062      65 VGVYYSSWSPYKPrlhyprnidfqrVTHVYYAFFVVDektgkigsldkwsd--------------------------tkm 118 Ashbya gossypii...
AAP49451      58 SLGYYPNWGVYAKkyfvtd-ipadhFTHLSYAFANVNnktgevylsdpyadlq-----------------------yayp 113 uncultured Neot...

Feature 1                                                                                     # #
1NH6_A       216 qkgvtawddpyKGNFGQLMALKQAHPd--LKILPSIGGWTLs--dPFFFMg-dKVKRDRFVGSVKEFlqtwkfFDGVDID 290 Serratia marces...
AAG35111     179 gdswndtgnnlYGNFKQFLLLKKKNRa--LKLMLSVGGWTFg--pHFAPMaadAKKRAKFVSTAITIlen-dgLDGIDID 253 Ustilago maydis
CAG77802      60 dkwtddsekqlHGCFYQFNLLKRQHRq--LKLFLSIGGYSFa--gNFAEMakdETKRKRFAESAAQHvin-lgLDGIDLD 134 Yarrowia lipoly...
Q06350       145 ssnnsvqnilpLGCIGELFYLKNTCSdkkFKVIMSIGGWSDs--eNFKIIikdDKLLQNFVDSSVETmfr-lgFDGIDLD 221 baker's yeast
XP_360159    104 ngtqggnssdaHGLVEQLYKIKQANRn--VKMLLSIGGYTWs--pKFVPVaadAGKRAAFVSSAVALmgd-wgMDGLDVD 178 Magnaporthe gri...
EAU86796     120 gdtwtetgnnlYGCLKQLYLLKMKKRd--LKVLLSIGGWTYsqagHFNFVt-nPTARAKFISDAVQLied-ygFDGIDID 195 Coprinopsis cin...
CAG99140     117 sdfelplsvgvKGCIKELQKIKLESKh-eFKTILCLGGWSNr--eAYKKIaksEKKVKKFIETAVDCmfr-ygFDGIDLD 192 Kluyveromyces l...
XP_001804658  95 pgdvatngsqlLGNFNQLYKLKQKNRn--LKVILSVGGWTWr--gNFKPAlatEAGRQKFCDSSLQLiad-lgLDGFDID 169 Phaeosphaeria n...
AAS51062     119 pmnltgmprglNGAIGELNYLKTRPGt-dFKLMMAVGGWSNr--ePFHKIvrdEEKFNNFIDSAIDAmfe-ygFDGIDLD 194 Ashbya gossypii...
AAP49451     114 gddtkakgnnlYGNFKQLYKLKKENRy--LNTLLAIGGFTYs--aNFGPVlasKPLRETFAKSAVKLvad-lgLDGLDLD 188 uncultured Neot...
AAG35111     179 gdswndtgnnlYGNFKQFLLLKKKNRa--LKLMLSVGGWTFg--pHFAPMaadAKKRAKFVSTAITIlen-dgLDGIDID 253 Ustilago maydis
CAG77802      60 dkwtddsekqlHGCFYQFNLLKRQHRq--LKLFLSIGGYSFa--gNFAEMakdETKRKRFAESAAQHvin-lgLDGIDLD 134 Yarrowia lipoly...
Q06350       145 ssnnsvqnilpLGCIGELFYLKNTCSdkkFKVIMSIGGWSDs--eNFKIIikdDKLLQNFVDSSVETmfr-lgFDGIDLD 221 baker's yeast
XP_360159    104 ngtqggnssdaHGLVEQLYKIKQANRn--VKMLLSIGGYTWs--pKFVPVaadAGKRAAFVSSAVALmgd-wgMDGLDVD 178 Magnaporthe gri...
EAU86796     120 gdtwtetgnnlYGCLKQLYLLKMKKRd--LKVLLSIGGWTYsqagHFNFVt-nPTARAKFISDAVQLied-ygFDGIDID 195 Coprinopsis cin...
CAG99140     117 sdfelplsvgvKGCIKELQKIKLESKh-eFKTILCLGGWSNr--eAYKKIaksEKKVKKFIETAVDCmfr-ygFDGIDLD 192 Kluyveromyces l...
XP_001804658  95 pgdvatngsqlLGNFNQLYKLKQKNRn--LKVILSVGGWTWr--gNFKPAlatEAGRQKFCDSSLQLiad-lgLDGFDID 169 Phaeosphaeria n...
AAS51062     119 pmnltgmprglNGAIGELNYLKTRPGt-dFKLMMAVGGWSNr--ePFHKIvrdEEKFNNFIDSAIDAmfe-ygFDGIDLD 194 Ashbya gossypii...
AAP49451     114 gddtkakgnnlYGNFKQLYKLKKENRy--LNTLLAIGGFTYs--aNFGPVlasKPLRETFAKSAVKLvad-lgLDGLDLD 188 uncultured Neot...

Feature 1         #                                                                              
1NH6_A       291 WLFPggkganpnlgspqDGETYVLLMKELRAMLdqlsve---------tgrkyELTSAISAGKDKIDKvaynVAQNSMDH 361 Serratia marces...
AAG35111     254 WEYPsd---------stQAANFVLLLKELRAGLtahqakk-------netnpyLLSIAAPCGPDHYKVlqvaKMDQYLDF 317 Ustilago maydis
CAG77802     135 WEYAdt---------deKAQQYVELLRAVRLELdsvalkt------gldrhtfGLSIAAPGSVWYAKHlkiaEMDQFLSF 199 Yarrowia lipoly...
Q06350       222 WEFPgnn--------esEPRGYLKLVRMLRLKLnslesqif----gkrtedhfQLSIAAPAFKDKLFYlpitEIDQYVDY 289 baker's yeast
XP_360159    179 WEYPdt---------aeTNKNCVLLLQELRRGLddysqqh------tgsqykfSLSMPAPAGPTHYAAfdfkAMDASLDF 243 Magnaporthe gri...
EAU86796     196 YEYPst---------peQGQGLADLVTSLRTALtqlasrk-------gesnpyLITAAVGAGPAGYSNlkvaQMDRAMDY 259 Coprinopsis cin...
CAG99140     193 WEFPeed--------snEPIVYLEMMRGIREGMdqlerqifgspaeekdhphfQLSVATPAFAEKLNIlpisEMSKYVDI 264 Kluyveromyces l...
XP_001804658 170 WEYAed---------atDAANFLDTVMRCRKAYdeyaaan-------ahgyhfDLGISAPAGPSRYSVlrmkEMDQYVDN 233 Phaeosphaeria n...
AAS51062     195 WEFPkdd--------gyEPQMYLEMCSRLRHKMdeledniwg--pggtteprfHLSMAAPAFPQTLGIfpveEMNKYLSM 264 Ashbya gossypii...
AAP49451     189 YEYVan---------skEAEEIVDLLRLLREGLdklnrds-------katapfLLTFASPAGEQRYKVlnfpEMSKYVDL 252 uncultured Neot...
AAG35111     254 WEYPsd---------stQAANFVLLLKELRAGLtahqakk-------netnpyLLSIAAPCGPDHYKVlqvaKMDQYLDF 317 Ustilago maydis
CAG77802     135 WEYAdt---------deKAQQYVELLRAVRLELdsvalkt------gldrhtfGLSIAAPGSVWYAKHlkiaEMDQFLSF 199 Yarrowia lipoly...
Q06350       222 WEFPgnn--------esEPRGYLKLVRMLRLKLnslesqif----gkrtedhfQLSIAAPAFKDKLFYlpitEIDQYVDY 289 baker's yeast
XP_360159    179 WEYPdt---------aeTNKNCVLLLQELRRGLddysqqh------tgsqykfSLSMPAPAGPTHYAAfdfkAMDASLDF 243 Magnaporthe gri...
EAU86796     196 YEYPst---------peQGQGLADLVTSLRTALtqlasrk-------gesnpyLITAAVGAGPAGYSNlkvaQMDRAMDY 259 Coprinopsis cin...
CAG99140     193 WEFPeed--------snEPIVYLEMMRGIREGMdqlerqifgspaeekdhphfQLSVATPAFAEKLNIlpisEMSKYVDI 264 Kluyveromyces l...
XP_001804658 170 WEYAed---------atDAANFLDTVMRCRKAYdeyaaan-------ahgyhfDLGISAPAGPSRYSVlrmkEMDQYVDN 233 Phaeosphaeria n...
AAS51062     195 WEFPkdd--------gyEPQMYLEMCSRLRHKMdeledniwg--pggtteprfHLSMAAPAFPQTLGIfpveEMNKYLSM 264 Ashbya gossypii...
AAP49451     189 YEYVan---------skEAEEIVDLLRLLREGLdklnrds-------katapfLLTFASPAGEQRYKVlnfpEMSKYVDL 252 uncultured Neot...

Feature 1           # ##                                                                      #  
1NH6_A       362 IFLMSYDFYGafdlknLGHQTALNapawkp------------------dtaytTVNGVNALLAqGVKPGKIVVGTAMYGR 423 Serratia marces...
AAG35111     318 WNLMAYDFAGsws-alTGHQANLWnikg---------------------appsADDSINYYIGqGVVSHKLVLGIPLYGR 375 Ustilago maydis
CAG77802     200 WNIMAYDFAGsws-pqSGHQSNLYgge------------------------isVDQIMNYYVQnGVASEKLILGMPIYGR 254 Yarrowia lipoly...
Q06350       290 WNMMTYDYYGsws-etTGYHSNLFsete----------------------lngNFAMHYMIDRfGVNSRKLVLGMAAYGR 346 baker's yeast
XP_360159    244 WSIMAFDFAGswd-ntTGHQANVYpgpdl-------------------ttkasIDVAVSDYVKaGVAPGKINLGLPLYGR 303 Magnaporthe gri...
EAU86796     260 WNLMAYDYAGswl-twADNQANFYggar---------------------tgysTDAALKWYISqGATKSKINVGMPLYGR 317 Coprinopsis cin...
CAG99140     265 WNMMCYDFHGews-dvTGYHSNLYlqghshrrsls--------nrisnsslssDTAVKLMTDRhNISSRRIALGMAAYGR 335 Kluyveromyces l...
XP_001804658 234 WNLMAFDYQGggfsnfTGHQSNVYasktnpkttdgw------dsvlgkfmpfnTKEAIDYYKAnVASPCKIVLGMPLYGR 307 Phaeosphaeria n...
AAS51062     265 WNMMTYDYHGaws-erTGYHSNLYnatnspykshldkrryedmgidnfdelnaHDAILMMTEQfKVSPRKIALGMAAYGR 343 Ashbya gossypii...
AAP49451     253 YNFMAVDYAGpsfskkTGYLDNLYadkknpd----------------atpfntASGIHYYLHEgKVPGSKIVVQNPLYGS 316 uncultured Neot...
AAG35111     318 WNLMAYDFAGsws-alTGHQANLWnikg---------------------appsADDSINYYIGqGVVSHKLVLGIPLYGR 375 Ustilago maydis
CAG77802     200 WNIMAYDFAGsws-pqSGHQSNLYgge------------------------isVDQIMNYYVQnGVASEKLILGMPIYGR 254 Yarrowia lipoly...
Q06350       290 WNMMTYDYYGsws-etTGYHSNLFsete----------------------lngNFAMHYMIDRfGVNSRKLVLGMAAYGR 346 baker's yeast
XP_360159    244 WSIMAFDFAGswd-ntTGHQANVYpgpdl-------------------ttkasIDVAVSDYVKaGVAPGKINLGLPLYGR 303 Magnaporthe gri...
EAU86796     260 WNLMAYDYAGswl-twADNQANFYggar---------------------tgysTDAALKWYISqGATKSKINVGMPLYGR 317 Coprinopsis cin...
CAG99140     265 WNMMCYDFHGews-dvTGYHSNLYlqghshrrsls--------nrisnsslssDTAVKLMTDRhNISSRRIALGMAAYGR 335 Kluyveromyces l...
XP_001804658 234 WNLMAFDYQGggfsnfTGHQSNVYasktnpkttdgw------dsvlgkfmpfnTKEAIDYYKAnVASPCKIVLGMPLYGR 307 Phaeosphaeria n...
AAS51062     265 WNMMTYDYHGaws-erTGYHSNLYnatnspykshldkrryedmgidnfdelnaHDAILMMTEQfKVSPRKIALGMAAYGR 343 Ashbya gossypii...
AAP49451     253 YNFMAVDYAGpsfskkTGYLDNLYadkknpd----------------atpfntASGIHYYLHEgKVPGSKIVVQNPLYGS 316 uncultured Neot...

Feature 1                                                                                        
1NH6_A       424 GWTGvngyqnnipftgtatgpvkg--------twengivdyrqiasqfmsgeWQYTYDATAEAPYVFKpstgDLITFDDA 495 Serratia marces...
AAG35111     376 GFENtdgpqqpyrgtgqgt------------------weagnwdykflpvkgAKEMINTKIAASWSYDsakrEFISYDTP 437 Ustilago maydis
CAG77802     255 SFAGtdglnkpytsvgegtqee-------------gswergvwdykklprpgFEAHFDDQCKASYLYNkdtkTLVTYDDV 321 Yarrowia lipoly...
Q06350       347 SFHIkdnkfepfnqntvlinkifkgvgkptkeidkadgkegiwpyknlpkigTIEQYDPKYVSAYCFDeknsIFISYDNT 426 baker's yeast
XP_360159    304 SFDKttglgkgytastagsl----------------egqagiwiykdlpragATVLYDDVAKASYTMDnstgQLISYDDL 367 Magnaporthe gri...
EAU86796     318 AFQNtdglgapysgigpgt------------------iepgiysykalplagGQVYENKTDMTSYSYDpvkrELVSYDTP 379 Coprinopsis cin...
CAG99140     336 GFTNvetnddnylgkkyhgvgg------------gsegepgiwlynqlpidgSKEQFDSNAVSAYCFDpksrTFVGYDNV 403 Kluyveromyces l...
XP_001804658 308 SFGNvvdlskdqrglgqkfngsg-----------egtwepgtldykflplngSKVYQDKETLSSWSWDpvkkEVVSFDTP 376 Phaeosphaeria n...
AAS51062     344 GFTNvrgdgeqligqkysgvgg------------gsegepgmwlynqlplahGPEKFDNVWVSAYSYDpntkTLVVYDNV 411 Ashbya gossypii...
AAP49451     317 AFNGtngigqsfkdaglqgsl--------------gtagtwfvkdlppkgfnLEVTNNKAVGGSYSYDkaqkYLIAHDTP 382 uncultured Neot...
AAG35111     376 GFENtdgpqqpyrgtgqgt------------------weagnwdykflpvkgAKEMINTKIAASWSYDsakrEFISYDTP 437 Ustilago maydis
CAG77802     255 SFAGtdglnkpytsvgegtqee-------------gswergvwdykklprpgFEAHFDDQCKASYLYNkdtkTLVTYDDV 321 Yarrowia lipoly...
Q06350       347 SFHIkdnkfepfnqntvlinkifkgvgkptkeidkadgkegiwpyknlpkigTIEQYDPKYVSAYCFDeknsIFISYDNT 426 baker's yeast
XP_360159    304 SFDKttglgkgytastagsl----------------egqagiwiykdlpragATVLYDDVAKASYTMDnstgQLISYDDL 367 Magnaporthe gri...
EAU86796     318 AFQNtdglgapysgigpgt------------------iepgiysykalplagGQVYENKTDMTSYSYDpvkrELVSYDTP 379 Coprinopsis cin...
CAG99140     336 GFTNvetnddnylgkkyhgvgg------------gsegepgiwlynqlpidgSKEQFDSNAVSAYCFDpksrTFVGYDNV 403 Kluyveromyces l...
XP_001804658 308 SFGNvvdlskdqrglgqkfngsg-----------egtwepgtldykflplngSKVYQDKETLSSWSWDpvkkEVVSFDTP 376 Phaeosphaeria n...
AAS51062     344 GFTNvrgdgeqligqkysgvgg------------gsegepgmwlynqlplahGPEKFDNVWVSAYSYDpntkTLVVYDNV 411 Ashbya gossypii...
AAP49451     317 AFNGtngigqsfkdaglqgsl--------------gtagtwfvkdlppkgfnLEVTNNKAVGGSYSYDkaqkYLIAHDTP 382 uncultured Neot...

Feature 1                            #     
1NH6_A       496 RSVQAKGKYVLDKQLGGLFSWEIDAD 521 Serratia marcescens
AAG35111     438 QNVLLKCQYIRNKRLRGAMFWELSGD 463 Ustilago maydis
CAG77802     322 NVVKLKSEYVRQKNLGGGMWWESSAD 347 Yarrowia lipolytica CLIB99
Q06350       427 KSVKTKAEYVTHNNLGGGFWWESCGE 452 baker's yeast
XP_360159    368 KSVQFKSDYVKQKQIGGVMFWESSQD 393 Magnaporthe grisea 70-15
EAU86796     380 NIVRMKAIYVEKNGLGGTMFWELSTD 405 Coprinopsis cinerea okayama7#130
CAG99140     404 QSMDIKGKYIKKKNLNGGFWWESCGD 429 Kluyveromyces lactis NRRL Y-1140
XP_001804658 377 KTAVWKTDFLKSEGLGGAWWWDSSSD 402 Phaeosphaeria nodorum SN15
AAS51062     412 DSMKIKKEYVKDKKLAGAFLWESCGD 437 Ashbya gossypii ATCC 10895
AAP49451     383 VTVRQKVDYVKKTKLAGTSFWEISQD 408 uncultured Neotyphodium
AAG35111     438 QNVLLKCQYIRNKRLRGAMFWELSGD 463 Ustilago maydis
CAG77802     322 NVVKLKSEYVRQKNLGGGMWWESSAD 347 Yarrowia lipolytica CLIB99
Q06350       427 KSVKTKAEYVTHNNLGGGFWWESCGE 452 baker's yeast
XP_360159    368 KSVQFKSDYVKQKQIGGVMFWESSQD 393 Magnaporthe grisea 70-15
EAU86796     380 NIVRMKAIYVEKNGLGGTMFWELSTD 405 Coprinopsis cinerea okayama7#130
CAG99140     404 QSMDIKGKYIKKKNLNGGFWWESCGD 429 Kluyveromyces lactis NRRL Y-1140
XP_001804658 377 KTAVWKTDFLKSEGLGGAWWWDSSSD 402 Phaeosphaeria nodorum SN15
AAS51062     412 DSMKIKKEYVKDKKLAGAFLWESCGD 437 Ashbya gossypii ATCC 10895
AAP49451     383 VTVRQKVDYVKKTKLAGTSFWEISQD 408 uncultured Neotyphodium

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