2DSK


Conserved Protein Domain Family
GH18_PF-ChiA-like

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cd06543: GH18_PF-ChiA-like 
Click on image for an interactive view with Cn3D
PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in archaea but also in eukaryotes and prokaryotes. PF-ChiA exhibits hydrolytic activity toward both colloidal and crystalline (beta/alpha) chitins at high temperature.
Statistics
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PSSM-Id: 119360
View PSSM: cd06543
Aligned: 37 rows
Threshold Bit Score: 265.31
Threshold Setting Gi: 53803113
Created: 1-Jun-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:2DSK_A; the catalytic domain of the hyperthermophilic chitinase from Pyrococcus furiosus binds glycerol, contacts at 4.5A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                                    #                                     
2DSK_A        10 HFFAPYIDMSLSvhkplv----------eyakltGTKYFTLAFILyss-vyNGPAWAGsipl---------ekfVDEVRE 69  Pyrococcus furi...
BAA06605      32 TEAAPYFFTWGYgessykfts-----lvdakqkaGLDAATLAFIItgs-sgCSLSNDVdn-------------mLSDVLA 92  Aeromonas sp. 1...
YP_001106083  32 IRTAPYVDITREsptlpe-----------iaqatGQKHFTLAFVLgss-agCDPQWGGqiplt-------epriVDQVTR 92  Saccharopolyspo...
YP_096229     27 PIFSPYVDLTINthwdsqsqdmepmdlispakklGIKAYHLAFITds--gqCQPAWGAqqnysv-----akgwgKKQFDT 99  Legionella pneu...
NP_630126     40 RVFAPYFEAWTGespaa------------laaqsGAKHLTMAFLQtatpgsCTPYWNGdtsmpi-----aqstfGADFDT 102 Streptomyces co...
ZP_02326598   66 KQYVPYFDVGAYpqnpllm--------ydymtktGTQQAFLGFLVtnp-qtDELVWSGsnkpvdvlqpngrdmiFDDIRR 136 Paenibacillus l...
YP_873791     40 YAQAPYVMPLDNsppdla----------tvmaatNEKAFMLAFILang-ssCSPAWDGtnpvs------sdttvANVINQ 102 Acidothermus ce...
YP_001828002 179 MAVAPYLYNGWGsppspt----------tvmnatGVKWFTLAFVLsn--gyCNPQWDGgrplv-------ggvdQRTINT 239 Streptomyces gr...
NP_822927    271 KQAAPYLYLGWGdppsat----------svmsstGIKWYTMAFMLds--ggCNPAWDGsrplt-------ggndQSVINS 331 Streptomyces av...
P14529         6 VSASPYLYNGWGnppspt----------evmnasGIKNFTLAFILad--gtCNPAWDGnrpl--------dgqdKATIDA 65  Saccharopolyspo...
Feature 1                  #                                       # # #                         
2DSK_A        70 LREIGGEVIIAFGGAVGPylcq----qasTPEQLAEWYIKVIDTYNATYLDFDIEAGid------adKLADALLIVQRER 139 Pyrococcus furi...
BAA06605      93 FQQQGGRLIISFGGAAVPmwk-----pavPAPRWPRWWMPCCNAPACVPLDFDIEGSqlsqt-alnsVRNEAIKTLQAKY 166 Aeromonas sp. 1...
YP_001106083  93 LREMGGDVIVASGGALGPyler----scrTADELLAAYRKTLDAVGANHLDIDVEASip------hdVVNEALARLQAER 162 Saccharopolyspo...
YP_096229    100 LSREGVKLTVSFGGASGTdis-----yhcDKNQLINTFSQVANQYHANVLDFDIENGtan-----ipNLLQALKLFQKEH 169 Legionella pneu...
NP_630126    103 IQANGGDVIPSFGGYTADttgteiadsctDVQQIAAAYEKVITTYDVSRLDMDIEIDaldnt-agidRRNKAIKLVQDWA 181 Streptomyces co...
ZP_02326598  137 LREQGKDLGIAVGGAGATmlpe----tvkSAEDAVKEYKEFLTAYGFTHLDFDIEGNltpdk-kgheNRAKVIKQLKKEL 211 Paenibacillus l...
YP_873791    103 VRSLGGDVSVSIGGYAGTklgq----vcsSPQATAAAYQAVIDKYALKAIDFDLEEPeyenl-tavsNEVGAAQILQRNN 177 Acidothermus ce...
YP_001828002 240 VRAAGGDVIPSFGGWSGNkles----scgSAGELAAAYQKVIDAYGLKAIDIDIEAAaydsp-tvqqRTVDALKTIRANN 314 Streptomyces gr...
NP_822927    332 VRSAGGDVVPSFGGWSGSklga----ncsSASALAGALQKVIDAYGLKAIDMDIENTdefenatvqdRILTALKTVKANN 407 Streptomyces av...
P14529        66 IRGAGGDVIPSIGGYSGSklge----vcqDSQSLAGAYQKVIDAYGLKAIDVDIEATefend-asetRVLEALKIVKEAN 140 Saccharopolyspo...
Feature 1                                                       ##                               
2DSK_A       140 p----wVKFSFTLPSdp-giGLA-GGYGIIETMAKKgvRVDRVNPMTMDYYwt----pSNAENAIKVAENVFRQlkqiyp 209 Pyrococcus furi...
BAA06605     167 p----dLYISFTLPTnp--tGLTsEGLNLLRGAQAAgvRTDVVNVMTMDYGasissgkKMGDLAVQAGNSLFTQlkgiyt 240 Aeromonas sp. 1...
YP_001106083 163 g-----TEISYTLRVqsddtGLDpYSYQVLQSAAAHg-VDVLVNPMTMEFGss----kPWGDAVIAAAESTLGQmrqiwp 232 Saccharopolyspo...
YP_096229    170 p----dVLLSFTLPVmp--eGLTsVGKEIITSAATLg-LHFNVNIMAMDYGpay--sgDMGDYAISAATNLHQFlqeiyp 240 Legionella pneu...
NP_630126    182 aangrdLEISYTLPTtt--rGLAsNGVALLENAVKNgtKVDVVNLMTFDYYdnq--qhDMARDTQTATQGLHDVlarlhp 257 Streptomyces co...
ZP_02326598  212 qsegqpLSVSYTLALgk--sGIEpKEVAIIEPAIKEgvDISRLNFMAFDYGei---neSLVETTIKALRSTHTTlkdlyq 286 Paenibacillus l...
YP_873791    178 p----gLYISITLPGta--sGTGyFGQNVLNTAKGLgfTPNNYSIMPFDGGf------NGAASQQSALQQFHTIlmntfg 245 Acidothermus ce...
YP_001828002 315 p----gIKLYVTFGT-----GQNgSDTSLINRAAQSglTVDSWTIMPFNFGgn---gqNMGTLSVRAAEGLKTAvkgayg 382 Streptomyces gr...
NP_822927    408 p----gLRTIVTFGTtt--tGPTyWGNRLIEQAQALnaGIDVFTIMPFDFGgg----sDMYGNTVNATDGLKAKlkstfg 477 Streptomyces av...
P14529       141 p----gLRTVVTFPTlv--nGPNdVGKRMIDKAARIgsDVDVWTQMPFNFGg-----gDMAADTITSTEGLVAHlksafg 209 Saccharopolyspo...
Feature 1                           #                                  #                         
2DSK_A       210 e----ksdeeiWKMIGLTPMIGVNDDKs--vFTLEDAQQLVDWAIQHKIGSLAFWSVDRDhpgptgevsp---lhrgtnd 280 Pyrococcus furi...
BAA06605     241 t----ksdaelWAMVGITPMIGKNDVQte-iFTTADATQVANFAKQYNIGLLSFWALQRDrsgsgsldd-----ysltpq 310 Aeromonas sp. 1...
YP_001106083 233 g----lsdaelKARLGVTPMIGRNFNGk--vFDQSHARQLVDWAAANRIGLLSFWSAGRDngrcpggpva--pdcssiaq 304 Saccharopolyspo...
YP_096229    241 d----kkpealWQMIEVTPMIGVNDVNte-qFTLSNAAQLKQFAQKNLLGGLSMWSFNRDkpcadkwaspv-csgnnlqs 314 Legionella pneu...
NP_630126    258 g----kssadlWHMIGVIEMIGVDDFGpaetFTLDNARTVYDWALDQGINTLSFWALQRDngscagggaa--dncsgiqq 331 Streptomyces co...
ZP_02326598  287 kygydktdadiWNLMGITSMTAQDDQGh--pFTLKDVQATIDFANSVGIPFLSMWSINRDsndnswv---------hpgt 355 Paenibacillus l...
YP_873791    246 -----wdsataWAHEGISQMNGRSDTGe--yFYQADFQSNLDFARSVGLGRYTFWSVNRDrqcpggatsttsgtcssvvq 318 Acidothermus ce...
YP_001828002 383 -----ysddqaYRHTGISSMNGTTDVGe--tITVADFRTILAYAQQRHLARLTFWSVNRDrpctgggad----tcsgvgq 451 Streptomyces gr...
NP_822927    478 -----wddataYSHIGISGMNGLSDQQe--nTSPATWTQIRDWANSHHIARLAFWSVNRDrpcpgggvvs---ncsgisq 547 Streptomyces av...
P14529       210 -----yddataYAHAGISSMNGKSDTGe--tVDQAAFQKMADYAGEKGLGRLSFWSVNRDrpcdgapd------acggid 276 Saccharopolyspo...
Feature 1                  
2DSK_A       281 pdWAFSHVFV 290 Pyrococcus furiosus
BAA06605     311 tdYQFYKAAK 320 Aeromonas sp. 10S-24
YP_001106083 305 sdYEFTRIFG 314 Saccharopolyspora erythraea NRRL 2338
YP_096229    315 hdYEFVKYFQ 324 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
NP_630126    332 ntWDFSHVFA 341 Streptomyces coelicolor A3(2)
ZP_02326598  356 qeGDYSKAFV 365 Paenibacillus larvae subsp. larvae BRL-230010
YP_873791    319 ndWDFTKFDV 328 Acidothermus cellulolyticus 11B
YP_001828002 452 qpWDFTRVLA 461 Streptomyces griseus subsp. griseus NBRC 13350
NP_822927    548 ntWQFTSITA 557 Streptomyces avermitilis MA-4680
P14529       277 qqWDFTKIVA 286 Saccharopolyspora erythraea NRRL 2338

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