1EOM,2EBN,1EDT,1EOK


Conserved Protein Domain Family
GH18_EndoS-like

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cd06542: GH18_EndoS-like 
Click on image for an interactive view with Cn3D
Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain. Some members also have an additional C-terminal glycosyl hydrolase family 20 (GH20) domain while others have an N-terminal domain of unknown function (pfam08522). Members of this family include endo-beta-N-acetylglucosaminidase S (EndoS) from Streptococcus pyogenes, EndoF1, EndoF2, EndoF3, and EndoH from Flavobacterium meningosepticum, and EndoE from Enterococcus faecalis. EndoS is a secreted endoglycosidase from Streptococcus pyogenes that specifically hydrolyzes the glycan on human IgG between two core N-acetylglucosamine residues. EndoE is a secreted endoglycosidase, encoded by the ndoE gene in Enterococcus faecalis, that hydrolyzes the glycan on human RNase B.
Statistics
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PSSM-Id: 119359
View PSSM: cd06542
Aligned: 23 rows
Threshold Bit Score: 188.741
Threshold Setting Gi: 29349395
Created: 1-Jun-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #                                     #                                    
1EOM_A        9 GVCIAYYITDgrn-------------ptFKLKDIpdKVDMVILFGLKywslqdttklpggtgmmgsfksykdlDTQIRSL 75  Elizabethkingia ...
NP_809961    54 PKAFGWFGNWtgeg----------aslvNSMAGIpdSVDVVSIWGNWsnit------------------eaqkKDLKFCQ 105 Bacteroides thet...
ZP_02067101  57 PVAFGWFGNWtgng----------atleKCLAGLpdSVDFVSIWGNWrnlt------------------eaqtKDLRYVQ 108 Bacteroides ovat...
NP_813620    53 EISYAYYEAWspiegvtg--ykdpaswgERMVGLpdSIDIVNLWMGIptaet----------------hpiayADMQYCQ 114 Bacteroides thet...
YP_213020    78 PIMFGWFNAWqpdg----------agkyPRLSLLpdSMDVVSIWGNWhsls-------------------eekIKELRSV 128 Bacteroides frag...
ZP_02068544  56 AICFGWYAGYtseas---------psqgLHFTGLpdSLDIVSLWSGIpsnnpayvets----yynerylptayEEMNYIR 122 Bacteroides ovat...
P36912       61 QISAGYYRTWrdsat--------asgnlPSMRWLpdSLDMVMVFPDYtppena--------------ywntlkTNYVPYL 118 Elizabethkingia ...
NP_809957    71 VKGFGWFGNWtgkg----------nnaqNYLKMLpdSVDFVSLWGTRgyls------------------deqkADLKFFQ 122 Bacteroides thet...
AAA67924     61 PIFFGYYRTWrdkaiqlkdddpwkdklqVKLTDIpeHVNMVSLFHVEdnqksdq------------qfwetfhREYQPEL 128 Corynebacterium ...
NP_809951    60 KIMFGWFGNWagkgg---------ssmqYALCGLpdSTDFVSLWLCWgnlt-------------------veqQADLKDF 111 Bacteroides thet...
Feature 1                                                                                       
1EOM_A       76 QSRGIKVLQNIDDdvswqss---------------------------------kpggfaSAAAYGDAIKSIViDKWKLDG 122 Elizabethkingia ...
NP_809961   106 EVKGTRFTMCFIItsvgtqitpqhiydnwesmgfasqqeavndfwgwpsdesdkeaveaSIRKYANAIADTI-NKYGYDG 184 Bacteroides thet...
ZP_02067101 109 NVKGTKALMCFIVqnigdqltpeeykd------------------nylefwgwnenkeeAIKKYAHAICDSI-DKYGYDG 169 Bacteroides ovat...
NP_813620   115 RKLGTRFVMHADAshyrhqftvdgv-----------------------dydlsqnkddeAMAAYAKWIVNQV-LEPGLDG 170 Bacteroides thet...
YP_213020   129 QAKGTKVIIGWIIedigdqikwg--------------------------rdqwpaddtqAIKEYAQAIVDTI-NKYGYDG 181 Bacteroides frag...
ZP_02068544 123 TVKGTRVVMCTICrigste----------------------------------fpktdaGIEAYALHLVRCV-LRNDLDG 167 Bacteroides ovat...
P36912      119 HKRGTKVIITLGDlnsattt---------------------------------ggqdsiGYSSWAKGIYDKWvGEYNLDG 165 Elizabethkingia ...
NP_809957   123 EVKGGKALLCWIIqdlgdqltpkglnat-----------------qywveekgqgnfieGVKAYANAICDSI-EKYNLDG 184 Bacteroides thet...
AAA67924    129 KKRGTRVVRTVGAqlllnkikdkn-------------------------lygkhveddyKYREIARDVYNEYvVKHNLDG 183 Corynebacterium ...
NP_809951   112 QAKGSRAVLCWRAgdigdnltpggnddavk-------------eafwgfdpkdeqscieAAKKYALAIVDTC-NKYNIDG 177 Bacteroides thet...
Feature 1        # # #                                                                          
1EOM_A      123 ISLDIEHSgakpnpiptfpgyaatgyngwysgsmaatpaFLNVISELTKYFgtta-----------------pnnKQLQI 185 Elizabethkingia ...
NP_809961   185 FDIDYEPNygnkgni------------------vddddrMFIFVDELGKHFgpks-----------------gtgKLLII 229 Bacteroides thet...
ZP_02067101 170 FDIDYEPNfghrgnm------------------sgsdenMLLFIQTLGERIgpks-----------------gtdRLLVI 214 Bacteroides ovat...
NP_813620   171 VDVDWEGWsg---------------------------sdLVRLIKELGKYFgpeg----------------eqpdKLLIV 207 Bacteroides thet...
YP_213020   182 FDYDYEPSyaspfkpgnhcgn------ltscsrdynkekEILFMKTMRELLgp---------------------dKLFHL 234 Bacteroides frag...
ZP_02068544 168 LDLDYEPEgdwl-----------------------qndnFTKFIKVLGNYFgpqs-----------------gtgKLLIV 207 Bacteroides ovat...
P36912      166 IDIDIESSpsga-----------------------tltkFVAATKALSKYFgpks-----------------gtgKTFVY 205 Elizabethkingia ...
NP_809957   185 FDIDYEPGyghsgtlany-----------qtispsgnnkMQVFIETLSARLrp--------------------agRMLVM 233 Bacteroides thet...
AAA67924    184 LDVDMELRqv---------------------------ekQLNLKWQLRKIMgafselmgpkapanegkkpdhegyKYLIY 236 Corynebacterium ...
NP_809951   178 FDYDIEDWgtlmns--------------------smpsvPNAFMKTLREEFdk--------------------tgKMLVA 217 Bacteroides thet...
Feature 1                                   # #                                                 
1EOM_A      186 ASgidvyawn---kimenfrNNFNYIQLQSYGanvsrtqlm--------------------mnyatgtnkIPASKMV-FG 241 Elizabethkingia ...
NP_809961   230 DGepqsik------nrpdvgPYFDYFIIQAYKpgndnnldkrlidggvagpglvqtygsvmseeqitkmtIMTENFEaVD 303 Bacteroides thet...
ZP_02067101 215 DGepqsi--------vsesgPYFNYFIVQAYDspgdntgrdnldsrl---------nstirnfdghltaeEVAKKYI-VT 276 Bacteroides ovat...
NP_813620   208 DYfsgtp--------ptdiiPYCDYIVQQAYSdqvgfl---------------------------tqpsnFPPEKMI-YC 251 Bacteroides thet...
YP_213020   235 NGsihwl--------dpraaQYFDRFVVQSYNgsassferw--------------------tndiqnrlnIKPEQLV-FT 285 Bacteroides frag...
ZP_02068544 208 DFynqlp--------pketePYVDYFVRQCYTtgsaqtlqs---------------------kfdqlsswCPPEKFV-AT 257 Bacteroides ovat...
P36912      206 DTnqnptn------ffiqtaPRYNYVFLQAYGrsttnltt----------------------vsglyapyISMKQFL-PG 256 Elizabethkingia ...
NP_809957   234 DGqpdll--------stetsKLVDHYIYQAYWesstssvi----------------------ykinkpnlDDWERKTiIT 283 Bacteroides thet...
AAA67924    237 DTfdnaqts-----qvglvaDLVDYVLAQTYKkdtkesvtq---------------------vwngfrdkINSCQFM-AG 289 Corynebacterium ...
NP_809951   218 DIpggagwlsfyevlseetvLSLDYIAWQTYElghsgldsffe----------------avrrshpnvfkEAMGKSI-VT 280 Bacteroides thet...
Feature 1                                                             #                         
1EOM_A      242 AYAEggt--------------------nqaNDVEVAKWTPTQg----AKGGMMIYTYNSNv---------SYANAVRDAV 288 Elizabethkingia ...
NP_809961   304 AAMDggypytd------------rygnsmkSLEGMARWQPKNg---fRKGGVGSYHMEAE----------YPTNPEYKNL 358 Bacteroides thet...
ZP_02067101 277 ENFEkwalsggadf-------tdrygnkmkSLEGMARWTPIIdgkkcVKGGVGTYHMEYEytidgteesyPYLRNAIRIM 349 Bacteroides ovat...
NP_813620   252 ESFGvfya-------------------dggQLMNYARWEPSKg----RKGGCGVFYLGRNy---------YSSSGIPYNE 299 Bacteroides thet...
YP_213020   286 ESFQnkpg------------------arsrFPGTYAGYVASKq---gNVGGIGVFHINEDa---------FEDEAYVNIR 335 Bacteroides frag...
ZP_02068544 258 EQMGwhwqnggvafteadgnkvdswgnpiySVIGMARWNPTQg----RKGGFGGYYFEYEynt-----trPANQAIGDKE 328 Bacteroides ovat...
P36912      257 FSFYeengypgnywn-----dvrypqngtgRAYDYARWQPATg----KKGGVFSYAIERDa---------PLTSSNDNTL 318 Elizabethkingia ...
NP_809957   284 VEFEqgwktggityyts-vrpelnsmegnqILDYATLDLPSGk----RIGGIGTYHMEYDy---------PNDPPYKWLR 349 Bacteroides thet...
AAA67924    290 YAHPeendtnrfl--------tavgevnksGAMQVAEWKPEGg----EKGGTFAYALDRDg--------rTYDGDDFTTL 349 Corynebacterium ...
NP_809951   281 ATFErav--------------------dkhYFTEQQSYHPACg---iEHAGMGAYHIEYDy---------PGNPDYPTVR 328 Bacteroides thet...
Feature 1        
1EOM_A      289 K 289 Elizabethkingia meningoseptica
NP_809961   359 R 359 Bacteroides thetaiotaomicron VPI-5482
ZP_02067101 350 N 350 Bacteroides ovatus ATCC 8483
NP_813620   300 F 300 Bacteroides thetaiotaomicron VPI-5482
YP_213020   336 K 336 Bacteroides fragilis NCTC 9343
ZP_02068544 329 K 329 Bacteroides ovatus ATCC 8483
P36912      319 R 319 Elizabethkingia meningoseptica
NP_809957   350 K 350 Bacteroides thetaiotaomicron VPI-5482
AAA67924    350 K 350 Corynebacterium pseudotuberculosis
NP_809951   329 A 329 Bacteroides thetaiotaomicron VPI-5482

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