Conserved Protein Domain Family

cd06541: ASCH 
Click on image for an interactive view with Cn3D
ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation. The domain has been named after the ASC-1 protein, the activating signal cointegrator 1 or thyroid hormone receptor interactor protein 4 (TRIP4). ASC-1 is conserved in many eukaryotes and has been suggested to participate in a protein complex that interacts with RNA. It has been shown that ASC-1 mediates the interaction between various transciption factors and the basal transcriptional machinery.
PSSM-Id: 119343
Aligned: 4 rows
Threshold Bit Score: 99.6624
Created: 8-Jan-2008
Updated: 17-Jan-2013
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1T62_B  25 VWMFGdgssemgnRLGQLVVSGRKTATCSSldiykmeeeqlPKAGQYDIILdgqs-qplAIIRTTKVEIMPm---nKVSE 100 Enterococcus faecalis...
1TE7_A   5 DITFFq-------RFQDDILAGRKTITIRDese------shFKTGDVLRVGrfeddgyfCTIEVTATSTVTldtltEKHA 71  Escherichia coli O157:H7
1XNE_A   5 RLYLKd-------EYLEMVKSGKKRIEVRVaypq----lkdIKRGDKIIFNd------lIPAEVVEVKKYEtf-rqVLRE 66  Pyrococcus furiosus
1WK2_A   7 GLIVRe-------PYASLIVDGRKVWEIRRr---------kTRHRGPLGIVsgg--rliGQADLVGVEGPFsv--eELLA 66  Thermus thermophilus
1T62_B 101 SFaqaegegdltlDYWYEEHARFFkeelapyqlqfypdmlLVCQSFE 147 Enterococcus faecalis V583
1TE7_A  72 EQen-------mtLTELKKVIADIypg----------qtqFYVIEFK 101 Escherichia coli O157:H7
1XNE_A  67 EPidkifpdkpsfEKALKRFHNMYpkwke-------yrygVLAIKFR 106 Pyrococcus furiosus
1WK2_A  67 HQek--------hLAEEAFLRAYAkd------------epLYAWVLE 93  Thermus thermophilus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap