Conserved Protein Domain Family
Glyco_transf_25

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cd06532: Glyco_transf_25 
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of Neisseria gonorrhoeae and Lic2A of Haemophilus influenzae. M. catarrhalis Lgt2 catalyzes the addition of galactose (Gal) to the growing chain of LOS on the cell surface. N. gonorrhoeae LgtB and LgtE link Gal-beta(1,4) to GlcNAc (N-acetylglucosamine) and Glc (glucose), respectively. The genes encoding LgtB and LgtE are two genes of a five gene locus involved in the synthesis of gonococcal LOS. LgtE is believed to perform the first step in LOS biosynthesis.
Statistics
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PSSM-Id: 133474
View PSSM: cd06532
Aligned: 154 rows
Threshold Bit Score: 69.5529
Threshold Setting Gi: 67524931
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ZP_01162697    2 KIFVINLPSSSDRrpfisk--kmediGIDFEFFSAIDGRKGLPqdlancpddk----hriyfrsrpLSSGEKGCYASHYR 75  Photobacterium ...
ZP_02907499    4 AIHVISLADSPRRatirr---avgrhGVDFDFEDAFDARALDAhacsamtdta----rviarygrpLSRGEVGCFMSHVR 76  Burkholderia am...
YP_001889720   7 PVHVISLPRSGRRgaiaa---llsgrGVAFRIEDAVDGRLLTHselnavyddt----aarrrygrsMTSAEVACFLSHRS 79  Burkholderia ph...
YP_002074547  27 KVFVITTGNEERVnriq-----nylkGIDFEFVYSDSYDDLLKlekeyesy-------shkfrqkaIMAGEIGCFKTHSQ 94  Vibrio sp. Ex25
ZP_02197153    7 HVFVIHVSEGYEErrqhidkhlpekgLHNYEYMLRGDIKDLTSevkak-------------yfqenDKLPELSCAYKHIL 73  Vibrio campbell...
YP_467251     42 RIFVVTVERAVERqervr----arlaGLDYRFHQGMDKRLLDParlaaegydaa-adrraarhskpMSQGQIACAVSHLQ 116 Anaeromyxobacte...
YP_001377577  14 RIFVVTLPRALERqarvt----srltGLDYRFFHGFDRQQLDLdrlaregvyaperarrvdrhgraLGAGQVGCSLSHRK 89  Anaeromyxobacte...
AAR27965       3 PVFVISLARSVERramvvq--qmahlGIDFEFVDATDGKALSSaelakvdfe-----lakevcghaLSFGEIGCAMSHIR 75  Aeromonas hydro...
Q9CLR6         6 PIFVISLKNSPRRdiiaq---rlnglKLNFKFIDGINGKTLSQdelnnidytf---ypqrfaarkpLTVGEIGCAMSHLS 79  Pasteurella mul...
ZP_01065593    3 KTFVIHVSKGYEErrkhidkhlpevgITDYEYMLAGDIDDLSDevrng-------------ffddsLRLPEKSCFYKHYL 69  Vibrio sp. MED222
ZP_01162697   76 LWQKCIELQ-QPIVILEDDCIPTSFfkqihtklpelhnegyeylrlqgq----------------------------qgq 126 Photobacterium ...
ZP_02907499   77 VWEKIVRSG-RAAIVLEDDAMLDDAlferfrstpnellsdhadlvllgrsklsrer--------------aaqaylyepl 141 Burkholderia am...
YP_001889720  80 VWRKIVDNG-CAAVILEDDAILEPAffervlhadesqlaavagivllgrsklrraa--------------sfwtylnepl 144 Burkholderia ph...
YP_002074547  95 AWELIVASG-TPAIVLEDNIEFIGEasrlladdvlsyiqscglvnftn------------------------------fc 143 Vibrio sp. Ex25
ZP_02197153   74 VYEEMVKRGiECALVLEDDAFLATDaltklrlveqemrdevnfiinieh----------------------------snr 125 Vibrio campbell...
YP_467251    117 VYRAAVENGwQRVLVFEDDVVPRGPdlallpealrqlpedwelaylgwsnfervtlrhrakqaaylvgaslrlmkwtpaq 196 Anaeromyxobacte...
YP_001377577  90 LYEQAIENGwSRVLVLEDDVVARDDdlpqltaalsqlpeawdvlylgytnfetvtrrdrvkqasyvvlsalrlmkwrpre 169 Anaeromyxobacte...
AAR27965      76 LYERIVAEGiERCVVLEDDIYLHMHskaiieaivhsckseivflhhgkakrw---------------------pflsslp 134 Aeromonas hydro...
Q9CLR6        80 IYQMMCNEKiARAIILEDDAIVSHEfeaivkdslkkvsknveilfydhgkaks-------------------ycwkktlv 140 Pasteurella mul...
ZP_01065593   70 VMKKVVEEQiPQVLVLEDDAFLNSDfieqleafqnelrgeekylvniee----------------------------ass 121 Vibrio sp. MED222
ZP_01162697  127 fkvieqlsdlqivlwkenliGTVGYSISPAGAKKLIAKSkk--wrCPVDNFI 176 Photobacterium sp. SKA34
ZP_02907499  142 krarrigglqigvpfkqwtsGAVGYWISADGARKALEHArgp-vgALLDDWP 192 Burkholderia ambifaria MEX-5
YP_001889720 145 rwrasvgglrvgvpfkqwtsGSVGYWISAQAARQALAYSegp-igALLDDWP 195 Burkholderia phytofirmans PsJN
YP_002074547 144 yildpekpfkisdvkekkpfPTVCYGITPLRARDLLSSMrktayaVPIDKWL 195 Vibrio sp. Ex25
ZP_02197153  126 svpfkvkqpgklcylashtkRCGGYIIHLEVAKKFVAFFdsnqtgLPIDAFQ 177 Vibrio campbellii AND4
YP_467251    197 ilrfhprpfsehlraaglhhCTHAYAFTLGAARKLVEAQrp--laRNADQLL 246 Anaeromyxobacter dehalogenans 2CP-C
YP_001377577 170 ilrfhprpfspnlrcaglhhCTHAYAFTLAGAKKLLAAQtp--vaFPADQLL 219 Anaeromyxobacter sp. Fw109-5
AAR27965     135 ggyrlaryltpsrtskrgvlSTAGYVLSLTGAKKLLQCAyp--lrMPSDYLT 184 Aeromonas hydrophila
Q9CLR6       141 enyrlvhyrkpsktskraimCATAYLITLSGAQKLLQIAyp--irMPADYLT 190 Pasteurella multocida
ZP_01065593  122 lvpasvrvpnqhlylcktnkLTGGLLYDLSFARAMVEHMesnitdAPIDGYI 173 Vibrio sp. MED222
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