2BOL,2BOL


Conserved Protein Domain Family
metazoan_ACD

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cd06526: metazoan_ACD 
Click on image for an interactive view with Cn3D
Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.
Statistics
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PSSM-Id: 107247
View PSSM: cd06526
Aligned: 129 rows
Threshold Bit Score: 48.6703
Threshold Setting Gi: 149431914
Created: 25-Jul-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
putative dimer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #####           # # ##                                        #                 
2BOL_A       222 GLEIVtaedgskKIHLELKVDPhFAPKDVKVWAKgnKVYVHGVtgkeektenashsehREFYKAFvTPEVVDAskTQAEI 301 beef tapeworm
2BOL_A       102 DAYEVgkd-grlHFKVYFNVKN-FKAEEITIKADknKLVVRAQksvacg----daamsESVGRSIpLPPSVDRnhIQATI 175 beef tapeworm
AAX26828      33 EMGEDgk----vHFNLRFDVKG-FEPEDIKVTLTdnYIKVQAKketkak----gssscREFCRLVeLPKSVDHdqLTCNL 103 Schistosoma jap...
129359       132 EVGEDgk----vHFKVRFDAQG-FAPQDINVTSSenRVTVHAKketttd----grkcsREFCRMVqLPKSIDDsqLKCRM 202 Schistosoma man...
AAK35217      97 EPGEDgr----vHFKVRFNVEG-YGPEDIQVNTSehGLTVHAKksvkde----kgtrmREFFRTIyLPPSVDKdhFQANM 167 Paragonimus wes...
AAW24545     249 ELGDDgk----vHFKVRFDAKD-FAPEDIEVTTVdnHLRVHAKksiksg----sttteREFRRSIdLPRSIDHehFQCHL 319 Schistosoma jap...
ABF01017      38 TPLSD-------DYEVSFDVKS-SKPEEIEVKVKdrTIHVEAKheered---elgfvsRQFARRFvLPQEFDPetISTFL 106 Belgica antarctica
XP_001639451  10 AKKESkd----dKFSMAMDVKG-FPPEAIKVQVLgnELLVSANhevehe----ghyhaMHFNRQFiLPREVDMdsLTTRL 80  starlet sea ane...
XP_001626168  21 ATKDDt------KFTLALDVSD-FKPEEVDVKVYghELSVRARqeseeh----gfftaRQFNRHFvLPREVDMdtLVPRL 89  starlet sea ane...
ABR57318      68 ALSTSq------YFQIRFDLSS-YKPENIRVVVRsgDVIVEAEhestcd----sysetETLRRRIrLPDKVDQsmLTSVL 136 Haliotis discus...
Feature 1           ##       
2BOL_A       302 Vd-GLMVVEAPL 312 beef tapeworm
2BOL_A       176 TtdDVLVIEAPV 187 beef tapeworm
AAX26828     104 TndGVLRLEAPV 115 Schistosoma japonicum
129359       203 TddGVLMLEAPV 214 Schistosoma mansoni
AAK35217     168 TedGILTLEAPV 179 Paragonimus westermani
AAW24545     320 TedGVLILDAPV 331 Schistosoma japonicum
ABF01017     107 NaeGKMTIKAAK 118 Belgica antarctica
XP_001639451  81 DkeGKLHFEAKK 92  starlet sea anemone
XP_001626168  90 AkdGVLYIEADK 101 starlet sea anemone
ABR57318     137 NaeGEMTIQAPF 148 Haliotis discus hannai

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