Conserved Protein Domain Family
GH25_Lyc-like

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cd06525: GH25_Lyc-like 
Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.
Statistics
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PSSM-Id: 119385
View PSSM: cd06525
Aligned: 15 rows
Threshold Bit Score: 226.409
Threshold Setting Gi: 182418596
Created: 28-Jul-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:
  • Comment:by similarity to other members of this superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                #                        #                            # #                    
P34020              2 KGIDIYSGqg-sVDFNAVKesGVEVVYIKATEGLTYTDSTYKDFYDGAKNAGLKIGFYHYlra---ndPTSEAEHFFNTi 77  Clostridiu...
ZP_02640278        10 KGIDISNWqk-gINLNQLKerGYDVCYIKITEGKGYVDPCFEENYNKAIAAGMKVGVYHYwrg--tssAIEQANNIVRTl 86  Clostridiu...
P26836             10 KGIDVSNWqg-nINFKSVKneGIEVVYIKATEGDYFKDSYAKQNYKRAKAEGLKVGFYHFfkp--nknAKRQAKYFIDYl 86  Clostridiu...
YP_001787252        2 KGVDISNNnqrpIDFNKIKasGVEIVYLKATEGTTFKDPYCNEYYNRAKAAGLKVGLYHFlvg--tsaPESQAENFYSMh 79  Clostridiu...
YP_001385248        3 KGIDISMHng-tVNFSAVKssGCNIVIIKATEGVNYVDPCLNQHYNGAKAQGLNIGFYHFmse--ktnPTQQAIDFWNAi 79  Clostridiu...
ZP_02210345         5 RGIDVSNWsg-yINWREVRdaGIEVAIIQASEGTFYRDPYLHEFYNGAKENGIKVGFYHFfnpgssptPSEQARYFVDTi 83  Clostridiu...
REF_tigr:CLH_2072   2 KGIDISNHng-eIKFASVKssGVELVYIKATEGTTYQDPMLNQYYNGANSEGLRTGFYHFlvg--tsaPESQAQNFYDNi 78  Clostridiu...
ZP_02948323        49 KGINISNNdg-nLDLSSVTqaGGKYVYLKATEGATFRDSYMDTYYNQCKDLGMKIGVYHYlvn--tssPEEQAENFYNTi 125 Clostridiu...
YP_878172          10 NGIDISNWqs-gINYDKLKr-NTEVVIIKATEGVDFIDKMFLTHYNGCKTAGLKIGFYHFfsd--ksnPTKQARDFWNTi 85  Clostridiu...
ZP_02088295        33 QGMDVSSWqg-dIDFQAVRaaGIQVVYLRAGVGLEYVDPYFQSNYEKALDAGLNIGYYHYvtaadtfqARQQAEFFYSLi 111 Clostridiu...
Feature 1                           # #                                #                      #       
P34020             78 sg---lslDCKCAIDVEvtlgq-sidqiSSNVRKFADYLINK-GLDVCVYTYTNFykdnln---stvkdLPLWIAEYGvs 149 Clostridiu...
ZP_02640278        87 gn---khiDCKIAIDVEqtdgl-sygelNNSVLQLAEELERLiGAEVCIYCNTNYarnvld---srlgkYSLWVAHYGvn 159 Clostridiu...
P26836             87 neigatdyDCKLALDVEttegr-sayelTTMCIEFLEEVRKItNREVVVYTYTSFannnld---nrlgvYPLWIAEYGvk 162 Clostridiu...
YP_001787252       80 kg---ktlEVLSNLDIErnn-----fnvMDYAIRFIKRFKELsGRNISIYAGPYFindnld---srlkqYPLWVAHYGvn 148 Clostridiu...
YP_001385248       80 kg---kqfNIIPTLDIEtnnmgrsqkqiSDRCIEFLTKFKALsGYNCLIYTGGYFgrdnld---sriksYPGWIAHYGvd 153 Clostridiu...
ZP_02210345        84 rg---ldsDLKLVLDLEqtggl-dnyevTRQAIEFLEEVRNYsGLDVAIYTYTNFaqynlye-glglseYPLWIAQLSeg 158 Clostridiu...
REF_tigr:CLH_2072  79 kg---ktnDLKPCLDIEkng-----fdvMDFALRFIKKFESLsGLPLCIYSYPYFinnnld---srlakYPLWVANYGvq 147 Clostridiu...
ZP_02948323       126 sk---ynwDLIPMLDTEvyf-----dglEDYIKRFKIAFNKLsPLKLGIYSYTSFidkylnnadseiyeMPLWEANYNgk 197 Clostridiu...
YP_878172          86 kn---kkmHVIPVLDIEtskrs--ktevTNRCLEFLKEMERLsGFKCIIYTYTSFaiekld---krlssYPLWIAHYGva 157 Clostridiu...
ZP_02088295       112 rd---kqiDCCPAMDFEsfpgl-stqeiNAIGLSFMETLGSLlGYDPALYTDSYNaaylws---sdfssYPLWVADYDvn 184 Clostridiu...
Feature 1                             #                #    
P34020            150 kpn-----idasYVGFQYSDSGSVNGis--gsADLDEF 180 Clostridium acetobutylicum
ZP_02640278       160 kpgd--npiwdkWAGFQYSENGTSNVng---sLDLDEF 192 Clostridium perfringens CPE str. F4969
P26836            163 apkd--nrvwssWIGFQYSDKGNVAGvs--gnCDMNEF 196 Clostridium perfringens
YP_001787252      149 kpman-kvwgssYAGHQFTEHGTIPGip--giCDVNNF 183 Clostridium botulinum A3 str. Loch Maree
YP_001385248      154 kpm----qtgfpVVGHQYTETGRVNGvs--gnVDLNNF 185 Clostridium botulinum A str. ATCC 19397
ZP_02210345       159 gpspn-piwgnkYVAWQYSDTGRVRGin--asTDLDLV 193 Clostridium bartlettii DSM 16795
REF_tigr:CLH_2072 148 tpipn-nvwgdsYVGHQYSETGNVNGin--gnVDLDTF 182 Clostridium botulinum E3 str. Alaska E43
ZP_02948323       198 pwssvgdnkftnLVGHQYSTEKHISDyigdfnGDLNEF 235 Clostridium butyricum 5521
YP_878172         158 sphn--ngiwnkWVGFQYTDKARIEGvp--ntCDANKF 191 Clostridium novyi NT
ZP_02088295       185 qpes--tgpwdsWDGFQYSDRGRVPGvn--gdVDMDFF 218 Clostridium bolteae ATCC BAA-613

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