Conserved Protein Domain Family
GH25_AtlA-like

?
cd06522: GH25_AtlA-like 
AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml autolysins from Streptococcus mutans which have a C-terminal glycosyl hydrolase family 25 (GH25) catalytic domain as well as six tandem N-terminal repeats of the GBS (group B Streptococcus) Bsp-like peptidoglycan-binding domain. Other members of this family have one or more C-terminal peptidoglycan-binding domain(s) (SH3 or LysM) in addition to the GH25 domain.
Statistics
?
PSSM-Id: 119382
View PSSM: cd06522
Aligned: 12 rows
Threshold Bit Score: 242.276
Threshold Setting Gi: 28377553
Created: 25-Jul-2008
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                #                           #                            # #                
BAG06149         773 SYFIDISSHNGiisvaef-nslkqqGIQGVVVKLTEGTSYINPYASSQIANARAAGIKVSAYHYAHYtsaagAQEEARYF 851  Streptococ...
REF_tigr:EF2174  164 KNFIDVSSWNGdisvaey-qkiksyGVTGVSVKLTEGTWYVNPYAAGQIRNAKAAGLKVSAYHYSMYvsaatAQDEARYF 242  Enterococc...
YP_818879         44 MDVVDVSSNNGtisvady-kkmqnyGVKAVIVKLSEADSYKNPYAKSQITNAKEAGLQVGAYHYSWYaskadAQAEAKYF 122  Leuconosto...
YP_001031589      92 QDAVDISDYQNwmvqsdf-nalkseGVKTAIIKLTEGTSYLNPSAAKQILMAKNAGLTVATYHFVYDpt--kIQNEAAFY 168  Lactococcu...
AAN64579         152 KTFVDVSSHNGsisvndy-rtlankGVGGVVVKLTEGTTYRNPYAGEQARNAQLAGLQVSAYAFSHYtseeqARAEARHF 230  Streptococ...
AAL00946          46 KDFIDISSNNGsiskdefqlmknqyGIKGVIVKLTEGDSYCNPLAPEQIANAQAAGLKVSVYHFSWFanpqeAAEEATYF 125  Lactobacil...
YP_805691          3 ILMADVSSWQPesdswf--rkladvGVKAVVVKLTEGTTYRNPKAAAQLAAGRRMGMQVHGYHYAHYhnsadAVAEGRFF 80   Lactobacil...
YP_795235          4 YDVVDTSNNNGimtvanw-rsmkkyGVKAMIAKLSEGTYFTDQTAKPSIRNAITAGLHVNGYHFARFttetgAKAEAQMA 82   Lactobacil...
NP_786398        229 VDVVDVASYQStmtqsdf-nklkaaGVKTVIVKSTEGTDYTNPAALNQAKMANKAGLNVDFYHYATFstadaAKSEATNM 307  Lactobacil...
YP_805541        115 VDTVDVASYQNgmtqany-nslrasGVKAVIVKSSEGSTYRNPYAAKQLAQAKAAGLKTAVYHYVHFanqsdAIAEANYF 193  Lactobacil...
NP_784445         31 MDMVDVSNNNGymstaeyvsmrnefGVRALTVKISEGTTFKDGYAASNIANGQAAGLYVNSYHFAHYktkaqAIAEADFA 110  Lactobacil...
ZP_03213033       14 NDVVDVSDWQSwmtqndy-tqlhnlGIKGVVVKVTEGTYYTNGIAANQIKFARNAGMVVSAYHYATFdsasaAVAEANYF 92   Lactobacil...
Feature 1                             # #                                  #                         
BAG06149         852 ANAARSFGLEASTVMVNDMEessm-----vnniNNNVQAWQDEMRRQGYsNLIHYTMASWldirggq----vytarfGIN 922  Streptococ...
REF_tigr:EF2174  243 AQAAANSGLDKNTIMFNDAEdptltn--ngrnaHANSVAFNQQLKALGYkNDALYVGKWWltngyi------dtsafGRD 314  Enterococc...
YP_818879        123 TNYAASLELPKDTLMVDDLEesytk----nssvTANATAFNAQVKAAGYtNTSTYTYVSYvnetnl------nfsyiGNN 192  Leuconosto...
YP_001031589     169 AQSAKALGLSTNTVMIEDAEapsq-----yynwTAVSQVFKSTMNKAGFnNIRYYTSQGWvssgvm------nastlGAK 237  Lactococcu...
AAN64579         231 ISEARNLNLPKNTVMVNDMEdakm-----kdniNRNTLAWADEMRKNGYtNLMYYTSASWidennlrgkgpvktaqfGLE 305  Streptococ...
AAL00946         126 MNYAKELELAQNTSFVNDYEsvns------pnaTSNALKFADTLKAAGFkNVYHYSSKSWfssvl-------dmtklGAK 192  Lactobacil...
YP_805691         81 GTTAKALGLSTESVMAADVEdpgl-----sgelTGLTNVFLQTVKAIGYpHTDLYTMASWlttrrf------drvalIPK 149  Lactobacil...
YP_795235         83 ARSALKAGLGKSSVIVLDFEatnsg----wnqnSKIVKAWINEVHRMGYpKTDVYTMGSWinsv---------plnnSGR 149  Lactobacil...
NP_786398        308 AGFLVKNNVSTKVLLFADMEdsssy----svnaTANLNAFWSTLDSFGYkNHGVYTSNSYlyrda-------vvktvGQS 376  Lactobacil...
YP_805541        194 ANTLDSLGFSKTSPVVADIEdsdv-----ggdvAANVNAFWNVLSTRGYvNHIVYTGLYYsyska-------aistvGNE 261  Lactobacil...
NP_784445        111 GQTAKAAGLPVGAVLATDVEsaeeqeilsqatnDRNNAAFMKEIQKFGY-RADIYTSGSWannk----------mtiKSK 179  Lactobacil...
ZP_03213033       93 ANRLDSLNVGKNVTVVADIEsdav-----sgdiAGNLKAFWQTMTQRGYqNHVAYTMRYYkhlda-------ltsttGKD 160  Lactobacil...
Feature 1              #                            #                  #     
BAG06149         923 NFWVAHYakgytymtqeeakslnyyanAAAWQYTSvssk------lshaLDENIDY 972  Streptococcus mutans
REF_tigr:EF2174  315 RVWVAQYpytpdss-------mqwnndHGAWQWSSqmyfpglanyegrpFDISMTY 363  Enterococcus faecalis V583
YP_818879        193 RVWMAQYpyqpsas-------slwnqsYGMWQWNSntsfp----gvkgtFDVSIDY 237  Leuconostoc mesenteroides subsp. m...
YP_001031589     238 NLWVAQYlygkpsn------qnlkntdYGSWQYTSqmyyqstpnlrshnLDTSIDY 287  Lactococcus lactis subsp. cremoris...
AAN64579         306 NFWVAQYptaklsand--aktlryngrAGAWQFTSqaell----pgkhvFDHSVDY 355  Streptococcus gordonii
AAL00946         193 TCWVAEWplnpsnd-------qllhtgNASWQWASdlyfpe--lgrtrqFDISTDY 239  Lactobacillus sakei
YP_805691        150 NLWLASYgvnqp-----------gvdnVGTWQFTNnfq--------glgVDMSYDF 186  Lactobacillus casei ATCC 334
YP_795235        150 GGWVANYpynpsg--------fklytgYNGWQWTSsmhfp----gcyggFDVSQMY 193  Lactobacillus brevis ATCC 367
NP_786398        377 RVWRAQYpytpsan-------nlwntnDGAWQFSDtallpsg-sdytgyIDVSIDY 424  Lactobacillus plantarum WCFS1
YP_805541        262 RAWVAQYpyvpsvd-------nllntgYGAWQFSSmagip----nyngrVDVSIDY 306  Lactobacillus casei ATCC 334
NP_784445        180 TGWVAGYpyvmsg--------qkwytnNNAWQWSGsahfr----isyggFDVSQLY 223  Lactobacillus plantarum WCFS1
ZP_03213033      161 RTWIAQYpytpsan-------slwdqdFGAWQFSStghlp----ghsqnLDVSIDY 205  Lactobacillus rhamnosus HN001

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap