Conserved Protein Domain Family
ACD_alphaA-crystallin_HspB4
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cd06497: ACD_alphaA-crystallin_HspB4 
Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaA-crystallin (HspB4, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Alpha crystallin, an abundant protein in the mammalian lens, is a large (700 kDa) heteropolymer composed of HspB4 and HspB5, generally in a molar ratio of HspB4:HspB5 of 3:1. Only trace amounts of HspB4 are found in tissues other than the lens. HspB5 does not belong to this group. Mutations inHspB4 have been associated with Autosomal Dominant Congenital Cataract (ADCC). The chaperone-like functions of HspB4 are considered important for maintaining lens transparency and preventing cataract.
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Statistics
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PSSM-Id: 107245
Aligned: 4 rows
Threshold Bit Score: 175.179
Created: 18-Mar-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
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putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #####     # # ##                                    #                    ## 
P02503     60 GISEVRSDRDRFVIYLDVKHFSPEDLTVKVLdDYVEIHGKHSERQDDHGYISREFHRRYRLPSNVDQSaISCSLSaDGML 139 North American opo...
O93591     61 GMSEVRSDRDKFMVYLDVKHFSPEELNVKVAeDYVEIQGKHGERQDDHGYISREFHRRYRLPSNVDQSaITCTLSaDGQL 140 Mexican tetra
Q91311     60 GISEVRSDRDRFTINLDVKHFSPDDLTVKILdDFVEIHGKHSERQDDHGYISREFHRRYRLPSNLDQSsISCSLSaDGIL 139 bullfrog
P02504     60 GISEVRSDRDKFTIMLDVKHFSPEDLSVKIIdDFVEIHGKHSERQDDHGYISREFHRRYRLPANVDQSaITCSLSsDGML 139 chicken

Feature 1           
P02503    140 TFSGPK 145 North American opossum
O93591    141 TICGPK 146 Mexican tetra
Q91311    140 TFSGPK 145 bullfrog
P02504    140 TFSGPK 145 chicken

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