Conserved Protein Domain Family
p23_NCB5OR

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cd06490: p23_NCB5OR 
p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining viable pancreatic beta cells. Mice homozygous for a targeted knockout (KO) of the gene encoding NCB5OR develop an early-onset nonautoimmune diabetes phenotype with a non-inflammatory beta-cell deficiency. The role of NCB5OR in beta cells may be in maintaining or regulating their redox status. Proteins in this group in addition contain an N-terminal cytochrome b5 domain and a C-terminal cytochrome b5 oxidoreductase domain. The gene encoding NCB5OR has been considered as a positional candidate for type II diabetes and other diabetes subtypes related to B-cell dysfunction, however variation in its coding region does not appear not to be a major contributor to the pathogenesis of these diseases.
Statistics
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PSSM-Id: 107240
View PSSM: cd06490
Aligned: 10 rows
Threshold Bit Score: 115.507
Threshold Setting Gi: 190584960
Created: 25-Mar-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7L1T6       170 YDWFQTDsLVTIAIYTKQKdi-nLDSIIVDHQndSFRAETIIk-dCLYLIHIGLSHEVQEdf-sVRVVESvGKIEIVLQK 246 human
XP_001233871 172 YDWFQTDdMITVVIYTKQKgm-nAELVIVDCQdrRLRGEIILd-dHSYLVEVDLDREVQGdf-aVNIGEKvGKVEIILKK 248 chicken
Q28CZ9       172 YDWFQTEsLVTVAVYTKMKnv-cSELVIVDHLenVLRGEIIIg-dYSYLLHSELSHPVQKdi-eVKVSATaGKIEIKMKK 248 western clawed ...
XP_001618515  71 YDWYQNDrIVTIAVYTRAKdiqmDSIILELKDqkDLNAIFILg-eKSYQLHLDLEEKVSNq--qVRIANDtGKVDLLLTK 147 starlet sea ane...
NP_001018496 178 YDWFQTDgTVNIVVYTKRKip-sAGCAVVDLQddNLRVEMLLg-rMSYLLYWRLSSRVQDhv-dVQTAHSvGKVQLCLRK 254 zebrafish
EDV25029     208 YDWYQSDkSITIVVYTKHKgltnEDILVNVKNnrKTDIWIVLg-dKILQLCLDLFEEICEs--eVKISTE-GNIEVILLK 283 Trichoplax adha...
XP_001360344 191 FDWIQQRsELTLFFYTRSFsn-pGLIVRRKDPq-QLVARVFLe-sRWHTFDLQLAGKVEWppkaVRVGTEtGKIELVLAK 267 Drosophila pseu...
AAY54856     190 FDWIQQRsELTLIFYTRSLan-pGLVVRRKDLq-QLSVRVLVq-hNWHSFDFQLTNNVEWppklAKIGSEtGKIELVFVK 266 fruit fly
XP_001868287 156 FDWIQKTaEVSFIFYTRALcn-pAVIVELVNNl-EFNVRFFLegnVLHRYRFQASNNLQWpc-tVRQSLEtGKVEIVFNK 232 southern house ...
XP_309336    149 FDWIQKTaELTLIFYTRSLan-pGVMVECVDHl-EVTVNILLessVQHRYRFHLANNVRWpc-tVRTSLEsGKIELMFNK 225 Anopheles gambi...
Q7L1T6       247 ken--tsWDFLG 256 human
XP_001233871 249 kdr--iqWKVLG 258 chicken
Q28CZ9       249 kep--vsWKSLG 258 western clawed frog
XP_001618515 148 depesqfWECTL 159 starlet sea anemone
NP_001018496 255 svk--ekWTQLG 264 zebrafish
EDV25029     284 qei-gkkWLSLG 294 Trichoplax adhaerens
XP_001360344 268 eep--apWSSYG 277 Drosophila pseudoobscura
AAY54856     267 eea--epWPTYG 276 fruit fly
XP_001868287 233 llp--glWTNYG 242 southern house mosquito
XP_309336    226 lcp--alWTSYG 235 Anopheles gambiae str. PEST
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