1RL1


Conserved Protein Domain Family
p23_CS_hSgt1_like

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cd06489: p23_CS_hSgt1_like 
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p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the heat shock proteins (HSPs) Hsp70 and Hsp90, and it expression pattern is synchronized with these two Hsps. The interaction with HSP90 has been shown to involve the hSgt1_CS domain, and appears to be required for correct kinetochore assembly and efficient cell division. Some proteins in this subgroup contain a tetratricopeptide repeat (TPR) HSP-binding domain N-terminal to this CS domain, and most proteins in this subgroup contain a Sgt1-specific (SGS) domain C-terminal to the CS domain. The SGS domain interacts with some S100 family proteins. Studies suggest that S100A6 modulates in a Ca2+ dependent manner the interactions of hSgt1 with Hsp90 and Hsp70. The yeast Sgt1 CS domain is not found in this subgroup.
Statistics
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PSSM-Id: 107239
View PSSM: cd06489
Aligned: 9 rows
Threshold Bit Score: 132.116
Threshold Setting Gi: 66566311
Created: 25-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RL1_A        13 DWYQTesQVVITLMIKNvqknDVNVEFSekELSALVKlpsGEDYNLKLELLHPIIPeqSTFKVLsTKIEIKLKKpeavrW 92  human
NP_001085215 142 DWYQTesQIIITVMIKNvqknNVHVQLSerELTIDMNlpsGENYSLNLHLLHTILPdqSVLKVLsTKVEIKLKKteairW 221 African clawed ...
XP_001175771  35 DWYQTdtLVTINILIKKakeeDVNIILTkiTLSATVKqptGSDYSLELDLAHPIVPekSTTRILnSKIEIRLKKeeairW 114 purple urchin
XP_971703     17 DWYQTdaAVVITVLVKNvkeeNLSVNFAktCVTAKIKfpeQDDIELKFNLSHEVVPeqCSYKITpSKIEVKLKKsegirW 96  red flour beetle
XP_623599     23 DWYQTesHVIVPILAKSa--kNVKVIYEknTLSVSALlpsGNEYSLELDLAHAIIPeeCSHKVDpSKIEIKLKKqdgitW 100 honey bee
NP_001007362 135 DWYQTesQVAVTIMVKNakkeGVIVSFGerELTAVVKlpsGEDYCLKVHLLHPIVPqqSTYKILsTKIEIKMKKteaiqW 214 zebrafish
XP_001632523 113 DWYQTetHVVVSVMIKNskqeDVYIEYGdqHLSVTVRlpsGNDYSLELDLAHPVSPsqCKTKILsTKIELKIKKleairW 192 starlet sea ane...
AAW26537       9 DWYQSegNVCINYFRKNlkpsDIRVEIEsrKILLYLTiptGDELLRKFHLLHDIVPekSSYRVTgTKVEIKLRKreevrW 88  Schistosoma jap...
EDV24493     160 DWYQTqtTVTIDILSKKvnprDFSIDFDanSVQVTFQdqhGNSRTISFNLCHDIIPsqSKAKILtTKIEIRLKKaegiqW 239 Trichoplax adha...
1RL1_A        93 EKLE 96  human
NP_001085215 222 ETLE 225 African clawed frog
XP_001175771 115 SKLE 118 purple urchin
XP_971703     97 AKLE 100 red flour beetle
XP_623599    101 TTLE 104 honey bee
NP_001007362 215 EKLQ 218 zebrafish
XP_001632523 193 SSLE 196 starlet sea anemone
AAW26537      89 SHLE 92  Schistosoma japonicum
EDV24493     240 TNLT 243 Trichoplax adhaerens
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