Conserved Protein Domain Family
p23_melusin_like

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cd06488: p23_melusin_like 
p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta subunits. Melusin is a muscle-specific protein expressed in skeletal and cardiac muscles but not in smooth muscle or other tissues. It is needed for heart hypertrophy following mechanical overload. The integrin-binding portion of this domain appears to be sequestered in the full length melusin protein, Ca2+ may modulate the protein's conformation exposing this binding site. This group includes Chordc1, also known as Chp-1, which is conserved from vertebrates to humans. Mammalian Chordc1 interacts with the heat shock protein (HSP) Hsp90 and is implicated in circadian and/or homeostatic mechanisms in the brain. The N-terminal portions of proteins belonging to this group contain two cysteine and histidine rich domain (CHORD) domains.
Statistics
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PSSM-Id: 107238
View PSSM: cd06488
Aligned: 17 rows
Threshold Bit Score: 142.436
Threshold Setting Gi: 190584890
Created: 25-Apr-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAF01676     218 CRHDWHQTdsLVVVTVYGQIplPAFNWVKASqtELHVHIVFdg--nRVFQAQMK-----LWGVINVeqSSVFLMpSRVEI 290 human
Q5ZML4       230 CRHDWHQTggEVTVSIYAKNsvPDLSYVEANstMLNIHIVFeg--eKEFHRNVK-----LWGVIDVkrSYVNMTaTKIEV 302 chicken
Q7T3F7       228 CRFDWHQTgsQVIISIYAKNsvPELSLVEGNstVLKIHIIFeg--eKEFEKQIS-----LWGVIDPskSLVNMMaTKIEI 300 zebrafish
Q6NUA0       229 CRHDWHQTgaGVTISIYAKNsmPELSYVEANstVVNIQVVFeg--eKTFQQNVQ-----LWGVIDVakSYVSLTaTKVEV 301 African clawed ...
XP_001634122 230 CRYDWFQMgnSVVISVYAKLtdPNATVIKANstQLSASIIFge--aSSFDLEIS-----LYGVIDPekSEVLMSpTKVEI 302 starlet sea ane...
XP_797726    308 CRHDWHQTgkMAVLSVYCKKsePSATVVQANqvSLDIQISFnq-qkSEFRKTIKlegvrINRVIDPgsSVVNMLgSKVEI 386 purple urchin
EDS40299     223 CRLDWHQTatQVVVTVYAKMchYRKSTVRLNpiRLAVCLVFpqqddQEYNVDLE-----LRGIVDVakSKVQMFgTKVEI 297 southern house ...
Q9U4A3       213 CRYDWHQTatNVVMAIYAKKydYSQSVIELNpiRLHVNLVFpeqdnARFDLDLE-----LRGIVNVsnASAHMYgTKVEI 287 fruit fly
EDV24959     217 VLYDWYQTgsNVYITIYAKLvnPERSLIEANhtIVKAFLIYgd-deKQYNKSIT-----LEGVILPekSLVQYLgTKIEI 290 Trichoplax adha...
XP_001742936 219 CRYDWFQSdtHVVLTVFAKCiePSRTSVKANadSITIDIVYsk--sFTFQLELH-----LGGNIIPaeSTVQLLsTKMDI 291 Monosiga brevic...
AAF01676     291 SLVKadpgsWAQLE 304 human
Q5ZML4       303 SMRKaepllWASLE 316 chicken
Q7T3F7       301 VLKKaepmsWARLD 314 zebrafish
Q6NUA0       302 FLKKaefmtWARLE 315 African clawed frog
XP_001634122 303 KLRKadigsWSNLE 316 starlet sea anemone
XP_797726    387 KLIKaesmsWKKFE 400 purple urchin
EDS40299     298 TLIKaepghWPKLD 311 southern house mosquito
Q9U4A3       288 TLPKlepgsWSNLN 301 fruit fly
EDV24959     291 KLKKfdtnsWNKLE 304 Trichoplax adhaerens
XP_001742936 292 KLAKapgeaWAALT 305 Monosiga brevicollis MX1
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