Conserved Protein Domain Family
ACD_HspB10

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cd06482: ACD_HspB10 
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB10, also known as sperm outer dense fiber protein (ODFP), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Human (h) HspB10 occurs exclusively in the axoneme of sperm cells and may have a cytoskeletal role.
Statistics
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PSSM-Id: 107237
View PSSM: cd06482
Aligned: 4 rows
Threshold Bit Score: 130.386
Threshold Setting Gi: 149431914
Created: 29-May-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #####       # # ##                                       #                    ##
Q14990       116 LASSCcssNILGSVNVCGFEPDQVKVRVKDgKVCVSAErENRYDCLGSKKYSYMNICKEFSLPPCVDEkdVTYSYGlgSC 195 human
XP_418368     88 YNASQd-hKVLAVMDVKGFDPEEVSVTVKDrKVQVLAEhEEAHTTTRGKEYNYKKVRKEFTLPPGVSEdeVMYSLGpnRV 166 chicken
XP_001516448   9 LVGDLdrsSVLASVDMCEFEPDQVKVKVKDgKVSVSAErENTYECLGSKNYSYMNICKEFNLPPGVDEkdVIYSFGtdNV 88  platypus
XP_001380297 115 LAASCcssNLLGSVNVCGFEPDQVKVKVKDgKVFVSAErENRYDCLGSKKYSYMNICKEFSLPPCVDEkdVTYSYGlgSC 194 gray short-tail...
Feature 1               
Q14990       196 VKIESPC 202 human
XP_418368    167 VKIETAH 173 chicken
XP_001516448  89 VKIETLC 95  platypus
XP_001380297 195 VKVEAPC 201 gray short-tailed opossum

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