Conserved Protein Domain Family
ACD_HspB9_like

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cd06481: ACD_HspB9_like 
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB9 and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. Human (h) HspB9 is expressed exclusively in the normal testis and in various tumor samples and is a cancer/testis antigen. hHspB9 interacts with TCTEL1 (T-complex testis expressed protein -1), a subunit of dynein. hHspB9 and TCTEL1 are co-expressed in similar cells within the testis and in tumor cells. Included in this group is Xenopus Hsp30, a developmentally-regulated heat-inducible molecular chaperone.
Statistics
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PSSM-Id: 107236
View PSSM: cd06481
Aligned: 7 rows
Threshold Bit Score: 100.17
Threshold Setting Gi: 167963464
Created: 27-Jun-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #####       # # ##                                         #                    
Q9BQS6        45 EDNDHardGFQMKLDAHGFAPEELVVQVDg-qWLMVTGQQqldvrdp-ervsyrmSQKVHRKMLPSNLSPTAMTCCLTps 122 human
232279        86 SGKDGk-dHFELTLNVRDFSPHELTVKTQg-rRVIVTGKHerksdtedgnyfheyREWKREAELPESVNPEQVVCSLSkn 163 African clawed ...
Q9DAM3        50 NGCEQp--SFQIKVDAQGFAPEDLVVRIDg-qNLTVTGQRqhesndpsrgryrmeQSVHRQMQLPPTLDPAAMTCSLTps 126 house mouse
AAB46594      79 LDKEGe--HFGLMLDTQGFSPEDLSVRQVg-rKLRVSGKTekkqedgkgsysyslQEFRQEFDLPEGVNHEDVRCHLSpd 155 Poeciliopsis lu...
NP_001010842  71 APAQGsgeGFSVCQDVKNFAPEQLSVKVVg-rKVVLVGQKetqntdekgsfsykyEVLKREWDVPEEVDAEALTCSPVpg 149 chicken
NP_001108177  79 DPEQKkkqDVSLTLDTRGFSPEDVSVTVSgrrLEVMAGKRaeknass-ssaesqaQEFVQAVQLPDHLDPASLTCSLGed 157 zebrafish
AAB04143      87 EGKDEk-eNFELSLDVSPFSPEELTVRTEg-rRLIVAGKSdkkretenggffqeyREWRREAELPEDVNPEDVLCSMSkn 164 bullfrog
Feature 1        ##       
Q9BQS6       123 GQLWVRGQC 131 human
232279       164 GHLHIQAPR 172 African clawed frog
Q9DAM3       127 GHLWLRGQN 135 house mouse
AAB46594     156 GKLHIQAAR 164 Poeciliopsis lucida
NP_001010842 150 GSCASRPPG 158 chicken
NP_001108177 158 GLLHIETPE 166 zebrafish
AAB04143     165 GRLHFWAPR 173 bullfrog

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