Conserved Protein Domain Family
ACD_HspB7_like

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cd06479: ACD_HspB7_like 
Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB7, also known as cardiovascular small heat shock protein (cvHsp), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. HspB7 is a 25-kDa protein, preferentially expressed in heart and skeletal muscle. It binds the cytoskeleton protein alpha-filamin (also known as actin-binding protein 280). The expression of HspB7 is increased during rat muscle aging. Its expression is also modulated in obesity implicating this protein in this and related metabolic disorders. As the human gene encoding HspB7 is mapped to chromosome 1p36.23-p34.3 it is a positional candidate for several dystrophies and myopathies.
Statistics
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PSSM-Id: 107234
View PSSM: cd06479
Aligned: 5 rows
Threshold Bit Score: 135.432
Threshold Setting Gi: 149383936
Created: 28-Apr-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative dimer
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #####      # # ##                                 #                    ##      
Q9UBY9        73 GNIKTLgdAYEFAVDVRDFSPEDIIVTTSNnHIEVRAEKLAADGTVMNTFAHKCQLPEDVDPtsVTSALRedGSLTIRAR 152 human
NP_001006040  64 GNIKTLgdTYQFTVDVQDFSPEDVIVTTSNnQIEVHAEKLASDGTVMNTFTHKCRLPEDVDPtsVKSSLGadGTLTIKAQ 143 zebrafish
NP_001086558  63 DNVKSVgtTFQFAVDVRDFSPEDIIVTTSNnQIEVHAEKLGADGTIMNTFTHKCQLPEDVDPttVTSALGedGNLTVKAQ 142 African clawed ...
XP_427836     51 GNVKTLgnTYQFTVDVSDFAPEDIIVTTSNnQIEVHAEKLAGDGTVMNTFTHKCQLPEDVDPtsVSSSLGdnGTLTIRAI 130 chicken
ABR24805      99 GVVRAVgeNYFLSADVSGFEPHEVVVLAYNqCVVIHAEKSGSDVGVSGRFTHKSVLPADMDPlsVSSSLTsdQTLIVSIR 178 zebrafish
Feature 1         
Q9UBY9       153 R 153 human
NP_001006040 144 R 144 zebrafish
NP_001086558 143 R 143 African clawed frog
XP_427836    131 R 131 chicken
ABR24805     179 R 179 zebrafish

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