Conserved Protein Domain Family
p23_DYX1C1_like

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cd06469: p23_DYX1C1_like 
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.
Statistics
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PSSM-Id: 107226
View PSSM: cd06469
Aligned: 16 rows
Threshold Bit Score: 90.7936
Threshold Setting Gi: 118348986
Created: 20-Mar-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001086864  10 WEQSenDVYISVPLKGtkasASNVLCSESYLKVNf--PPFLFEAFLFAPIDDs---tSSAKIGn----GVILFNLHKKep 80  African clawed ...
XP_001744855  10 WTQTddEVHLEVPLKGvhpkKADVYTNDVFVKVNa--PPFLFEVDLFAAIDDg---aSKAVIGn----GVAVFTLVKRep 80  Monosiga brevic...
XP_971936     10 WSQTdnTVTIKVPLRGihhsKVDIFYSKLYIKASf--EQYFFEVFLYKQIDPk---tSSCTFTs----THILFELIKCea 80  red flour beetle
XP_001701383   9 WTETdvAIEVTVEVPGvsksKADVFATDAFLKVNs--PPYLFALDLAKDVDDt---rSSATILp----GKVVFTLFKRep 79  Chlamydomonas r...
XP_787717     10 WEESdtDVHITVPIKGnnssKADLFSSDEYIKVNs--PPYFFEMFLYAGVDDs---kSVAQLGd----GVIVFKLIKKel 80  purple urchin
EDS36216      10 WSQEadQVTIRVQFPEnylrPEEVFTSEQFLKINk--PPYYWEALLANPILDr---eSRCAILe----NEVVFNLRKKep 80  southern house ...
XP_829662     30 WEQTntEVLLRITIKGfkkeAIDIFVSDLLVKVNa-sPTYLLVLDLLHPIDEa---kSTHFMDpe-drTCLRVRLRKRvp 104 Trypanosoma bru...
XP_001007966  28 WYQDnkIVKIRIPIKGitmkKIDIFISDLVLKINiteKKWVRVLDLKHEIDFqgqenNVVYAN-----EVLEIILVKKee 102 Tetrahymena the...
XP_001467975   9 WEQTgeDVLLHITIKGckkdAVDVLIADVFVKVNa-pPQYLLALDLLHAIDSs---kSSQYFTdaqdgIILHVKLHKAev 84  Leishmania infa...
CAJ14164      21 SSQSvvSIVLRVPFPAnrfqPDDIFTMEQFLKISh--PPHYWELFLAHPIDAd---aSHCSILe----NEVVFELVKQdp 91  African malaria...
NP_001086864  81 -avWDALT 87  African clawed frog
XP_001744855  81 -atWPTLH 87  Monosiga brevicollis MX1
XP_971936     81 -ttWENLE 87  red flour beetle
XP_001701383  80 -gvWGVLA 86  Chlamydomonas reinhardtii
XP_787717     81 -giWGQLS 87  purple urchin
EDS36216      81 gleWTLLE 88  southern house mosquito
XP_829662    105 -elWESLC 111 Trypanosoma brucei TREU927
XP_001007966 103 kkhWEDLI 110 Tetrahymena thermophila SB210
XP_001467975  85 grvWDALS 92  Leishmania infantum JPCM5
CAJ14164      92 tvcWDTVE 99  African malaria mosquito
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