1X5M


Conserved Protein Domain Family
p23_CacyBP

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cd06468: p23_CacyBP 
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p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter two are components of the ubiquitin ligase that regulates beta-catenin degradation. The beta-catenin gene is an oncogene participating in tumorigenesis in many different cancers. Overexpression of CacyBP/SIP, in part through its effect on the expression of beta-catenin, inhibits the proliferation, tumorigenicity, and invasion of gastric cancer cells. CacyBP/SIP is abundant in neurons and neuroblastoma NB2a cells. An extensive re-organization of microtubules accompanies the differentiation of NB2a cells. CacyBP/SIP may contribute to NB2a cell differentiation through binding to and increasing the oligomerization of tubulin. CacyBP/SIP is also implicated in differentiation of erythroid cells, rat neonatal cardiomyocytes, in mouse endometrial events, and in thymocyte development.
Statistics
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PSSM-Id: 107225
View PSSM: cd06468
Aligned: 27 rows
Threshold Bit Score: 83.0815
Threshold Setting Gi: 71411176
Created: 19-Mar-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1X5M_A        20 ISNYGWDQSdkFVKIYITLTGVhqv--pteNVQVHFTerSFDLLVKnl-------nGKSYSMIVNnLLKPISVegSSKKV 90  human
XP_001426942  91 FAFYDADEMnvRVVVELKDIAKhp----leKFQARFFekSFEIKIHdy-------qNKNWTFGVArTQCKLDAanSKFTL 159 Paramecium tetr...
XP_001013862 111 FSFFESGDWsvKVNIDLPGIQNhd----isKIQCRFLetSFELKIHef-------kGKNYLFSVPrASNKIDFnkSKIQI 179 Tetrahymena the...
NP_564346     76 LGTFSWDQDndKVKMYISLEGVde-----dKVQAEFKpmSLDIKIHdv-------qGKNYRCAIPkLCKEIMPekCKVLV 143 thale cress
XP_001449193  71 ITKYAWDQEgnKIKIIISLDGIgql--pkeNIISSFSthSVDVKILny-------kGINQRFGIKkTFDDLKDreCSIKT 141 Paramecium tetr...
ABK21098      68 LGSFSWDQDneKIKVYLFLEGVnq-----eKVISDFQpwSFDVKLHdi-------qGKNYRCGVPkLNKAIVPekCRLTV 135 Sitka spruce
XP_001015416  79 LTKYAWDQNgqNVNVSLYIDDIskv--npsNVQVTFTdqSFEVKVLdl-------nGRNYKFAIPkLYDKIKPseCKYVI 149 Tetrahymena the...
XP_001777324  77 LSTFSWDEEseKVKIYISLEGAaq-----eKVEADYQeqSVNLKIHdv-------nGKNYQFAVPrLAKKIVPsaCKFLV 144 Physcomitrella ...
XP_001460847  70 ITKYAFDQEesKITIIINMEGIgel--pkqNIQVEFGknCFDVRVIgy-------rNANHRLQIKkTFGDFLHkmSSFKV 140 Paramecium tetr...
XP_807848     77 VTKYSWCDAenAVTVYVDTKVEgqesladgTLQVEFKkrTLSLSYVanvvsskatpLQRKKQLLLhLSKSINVdkSEYKV 156 Trypanosoma cru...
1X5M_A        91 Kt--DTVLILCRKkventrWDYLT 112 human
XP_001426942 160 Kg--DKILITLRKvkkednWFSIH 181 Paramecium tetraurelia strain d4-2
XP_001013862 180 Ke--NQVTIVIRKnskddhWLSLH 201 Tetrahymena thermophila SB210
NP_564346    144 Kp--KRIVITMVKssr-gnWLDIH 164 thale cress
XP_001449193 142 Tn--NSLIVNLIKken-khWDQLA 162 Paramecium tetraurelia strain d4-2
ABK21098     136 Kp--QRVIITLQKaek-gnWQDIY 156 Sitka spruce
XP_001015416 150 Ks--SSISIKMKAtk--syWSQLT 169 Tetrahymena thermophila SB210
XP_001777324 145 Kp--KRVILTLKKadl-gsWFELT 165 Physcomitrella patens subsp. patens
XP_001460847 141 Tk--NNIHVILILpdk-tqWTQIK 161 Paramecium tetraurelia strain d4-2
XP_807848    157 KepsGQVVLRLVKekpskwWELVK 180 Trypanosoma cruzi strain CL Brener
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