Conserved Protein Domain Family

cd06463: p23_like 
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Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.
PSSM-Id: 107220
View PSSM: cd06463
Aligned: 333 rows
Threshold Bit Score: 34.955
Threshold Setting Gi: 123892457
Created: 24-Apr-2008
Updated: 2-Oct-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1WFI_A        12 WTQTl-----aELDLAVPFRVsfrlkgkDVVVDIQr-rHLRVGLKg-------QPPVVDGE-LYNEVKVeeSSWLIEd-- 75  house mouse
CAL56572      51 WTQTt-----tTVEITVALPKgtr--arDLRITLTt-tSLTFWATws-----gTVDACSGA-LARRCKVdeSTWSCDg-- 114 Ostreococcus tauri
CAL56400     173 WRQNq-----sFVEIFVKLPRgtt--ksDVDVSLSa-tRLSIRVR--------GDVIVNGD-LFAAIKAelSTWVIId-- 233 Ostreococcus tauri
XP_001892432 293 WSQTg-----tDVTAVFTYDEtil--kkDVLLSLSa-tSVHLSVK--------DIILIGGI-LGGSVDPtsSTYTIDd-- 353 agent of lympha...
NP_572755    298 WSQTd-----nNVLIRFNVPStas--akEFNVSGS---KTTVVVKh------lDEVIFDEE-LYASVGDdlSAFKLAe-- 358 fruit fly
NP_732260    140 WSQTl-----kDVEVQALLPKdhq-takKLHISIQa-qHIKVSSKhs-----pETIILEGN-LSQRIKHkeAVWTIDq-- 204 fruit fly
XP_001875774 296 WNQTp-----nSVTIAFPLPSdtl--ksQIHVSFSs-nALTLSTDittstaapPPSYLNKP-LWDGILSssSYWTWDrea 366 Laccaria bicolo...
XP_001835955 248 WSQTp-----dSVIVAIPLPSats--knNIRVAFSv-kAITVHVDyqas-tsiPIPRYSAKeLWDTISPssSLWTWDksa 318 Coprinopsis cin...
XP_829211     12 WSQGdegdtalEICVPIVLPQsgr--akELTVEVKdlaVLRVSHR--------DTIILQWR-LYEPVAEe-VEWRVEne- 78  Trypanosoma bru...
XP_001566265  14 WTQGeddetclEVRIPCVLPDgvr--prELTVDIKdscILCISHK--------ETRILQWR-LYAPVNDe-VEWRMEd-- 79  Leishmania braz...
1WFI_A        76 ---gKVVTVHLEKink-----------mewWNRLV 96  house mouse
CAL56572     115 ----DELMIILVKddggr--------dgvpWQSVL 137 Ostreococcus tauri
CAL56400     234 ----GVLEMSLLKknrrghydngcdnshtyWRSLV 264 Ostreococcus tauri
XP_001892432 354 ----NKLELFLVKsgg-----------ltnWSELV 373 agent of lymphatic filariasis
NP_572755    359 ----NGLELSLTKaei------------qnWPRLF 377 fruit fly
NP_732260    205 ----NRLIISYDKake------------lwWDRLF 223 fruit fly
XP_001875774 367 ehtcGLLTLYLTKrne-----------gtrWMQVF 390 Laccaria bicolor S238N-H82
XP_001835955 319 ehsyGLLTLHLEKqhe-----------gtrWMHVF 342 Coprinopsis cinerea okayama7#130
XP_829211     79 ---gSLLIMDMVKrsc------------avWPCLL 98  Trypanosoma brucei TREU927
XP_001566265  80 ---dNILVVELDKrsg------------apWSCLL 99  Leishmania braziliensis MHOM/BR/75/M2904
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