Conserved Protein Domain Family
SufS_like

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cd06453: SufS_like 
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Statistics
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PSSM-Id: 99746
View PSSM: cd06453
Aligned: 103 rows
Threshold Bit Score: 396.836
Threshold Setting Gi: 83816050
Created: 27-Jun-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalyticpyridoxal
Feature 1:catalytic residue [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_354805     27 TYLDNGASAQKPQVVIDAVshay-sneyANVHRGLHFlsnaaTDAYEAAREKVRRFLNagsvDEIVFTKSSTEAINTVAY 105 Agrobacterium t...
YP_357142      3 IYLDNAATSFPKPASVYQAvddalrhrgGSPGRGSHHmaleaGRLLMACRDTAAGFFGirdtSRVVFTGNATEALNLALF 82  Pelobacter carb...
ZP_01389159    3 VYLDNAATTFPKPDPVYGAvehalreigVGPGRGGYKrslaaSRLVFEAREILASFFGitdsSRLVFTHSATEGLNIAVN 82  Geobacter sp. F...
YP_902158      9 IYLDNAATSHPKPECVYQAvvhamrhigASPGRAGHRrsleaSRLLFQVREAIATLLSvpdsSRIIFTHSATEALNLALQ 88  Pelobacter prop...
ZP_01775900    3 VFLDNAATSFPKPETVYLAmdaalrevgVAPGRGGYRqslaaARIVYEARSALARFFGvsdsSRLIFTHSATESINIAVN 82  Geobacter bemid...
ZP_01094456    9 IYLDNAATSWPKPPGVIEAmrrhleqigAPAGRSGYHeaavvERAVSETRRQLAYLLGvreaERVVFTFNGTDSLNTVMH 88  Blastopirellula...
YP_001319833   3 VYLDNAATSYPKPREVLDAvydfmlnngATSGRGAYErammaDGLVYDTRKMIANLFNfhdpKKVIFTANITESLNLAIK 82  Alkaliphilus me...
YP_001319667   3 VYLDNAATSYPKPKEVVDAvydfmlnngATSGRGAYErammaDGLVYDTRKMIANLFNfhdpKKVIFTANITESLNLAIR 82  Alkaliphilus me...
YP_845332      3 LYLDNAATSFPKPPSVYEAvrhaltevgASPGRASHRharlaSSMVGAAREKVASFLGigdaDRVIFTKNATESINIVLK 82  Syntrophobacter...
ZP_01690598   17 THLNNAGAALIPQAVIDVQrdy----mnQEANYGGYEtaakfADELQTTYTRVARLINaq-pSEIALVESATVAWGKAFF 91  Microscilla mar...
Feature 1                                                                                        
NP_354805    106 GYGmpvigeGDEIVISIMEHHSNIVPWHfirerqGAKLVWVPvDDDGAFHIEAFEKSlte------rtKLVAITHMSNAl 179 Agrobacterium t...
YP_357142     83 GLLn----pGDRVVTSTMEHNAVLCPLQalq-trGLKVVKVPpGADGRLHPDSVREAvmvd---akatRLVVLTHASNVt 154 Pelobacter carb...
ZP_01389159   83 GLLk----pGDHVVTTTMEHNSLVRPLYaak-nrGVQITWVSaDRNGSIDPAAISAAlrp------etKLIALSHCSNVt 151 Geobacter sp. F...
YP_902158     89 GVLl----aGDHVVTTSMEHNSLLRPLYqlr-rrGVELTIVEaAGDGLVDPDAVRRAfrp------ttRMLALGHVSNVc 157 Pelobacter prop...
ZP_01775900   83 GLLk----pGDHVVSTRVEHNALLRPLHlaa-srGVEVTYVPsDRFGVVSEREIERAmrp------gtRLVALAHCSNVt 151 Geobacter bemid...
ZP_01094456   89 GFLr----aGDHVVTTTIEHNSVLRPLAylasrrGIEVRHAApDAQGVVSPQAIEEAlne------ksRLIVISHASNVt 158 Blastopirellula...
YP_001319833  83 GIVk----kGDHVITSSLEHNAVWRCLKtlerdrGISLSVVPaAKEGYINPLDVKDLirk------ntTLIVLNHASNVf 152 Alkaliphilus me...
YP_001319667  83 GIVk----eGDHVITSSIEHNAVWRCLKtlerdrGISLSVVPaSKEGYTNPLDVKDLiqk------ntVLIVINHASNVf 152 Alkaliphilus me...
YP_845332     83 GWLk----rGDRVLISAMEHNSVVRPLKrls-eiGVSTEIVPcSGSGAIDVDELRRRles------rpRLMAMTHASNVn 151 Syntrophobacter...
ZP_01690598   92 ALDlq---pGDRVATAMAEYASNYINYLqaqkthGIKIEVVPnDKHGQLSLEALEQLlaedkasegkiKLISITHVPTNg 168 Microscilla mar...
Feature 1                                                        #                               
NP_354805    180 GTILPVKEICRIAHERgIPVLVDGSQGavHMPVDVrdidCDWYVMTGHKLYGp-sGIGVLYGKTERLREMRPfqgggemi 258 Agrobacterium t...
YP_357142    155 GAIQPIEEIGPWCRSLgIPLLVDAAQTagYIPVDVedmgIDLLAVPGHKHLMgppGCGFLYVREGLQLTPLLyggsgsds 234 Pelobacter carb...
ZP_01389159  152 GTIQPIASIGDTARKAgVFFLVDAAQSagCMPINImdqkIDLLAVPGHKGLLgpqGTGLLYIAEHVDLSPFLlggtgtss 231 Geobacter sp. F...
YP_902158    158 GAIQPVARLATIAREAgALFLLDAAQSagSIPIDAaglgVDLLAAPGHKGLLgpqGTGFLFVAEGVEIRPLLaggtgsns 237 Pelobacter prop...
ZP_01775900  152 GAVQPIEAIARVARQNgAVFLVDAAQSagFFPIEAertgIDLLAAPGHKGLYgppGTGVLTIAEGLNLEPLLvggtggsa 231 Geobacter bemid...
ZP_01094456  159 GALQPIEAITEMAHRRgVRVLVDGAQTagHTPIRLeesgVDFFACSGHKGLLgplGVGVLYLAPGAEIETESfrqggtgt 238 Blastopirellula...
YP_001319833 153 GTIQPIGEIGAIARENsIPLLVDAAQTagVLPIDIkednIDLLAFTGHKSLLgpmGTGGLIVNWDGEIDPLKsggtggds 232 Alkaliphilus me...
YP_001319667 153 GTIQSIGEIGAIAREHsIPFLVDAAQTagVLPIDIkkdnVDLLAFTGHKSLLgpmGTGGLVVNWDGEMDPLKvggtggds 232 Alkaliphilus me...
YP_845332    152 GALLPAEAVAQMCSEFgVPLLLDAAQTagVQAIRAdkwrLAMLACSAHKGLLgppGVGVLFIRSGLDVEPLLeggtgsrs 231 Syntrophobacter...
ZP_01690598  169 GLVNPAEEVGKLAKKYgVLYLLDACQSvgQLPVDVqqigCDMLSATGRKYLRaprGTGFLYVSERILQDLEPkvldltsa 248 Microscilla mar...
Feature 1                                                                                        
NP_354805    259 ldvsednvtynepphRFEAGTppiVQAIGLGYALDYMdnlgr-aaiaaHEADLAAYAATRLRevnslrii--gnapdkgg 335 Agrobacterium t...
YP_357142    235 gs----plppehmpeRLESGTanlPALAGLKAGIDFLektgf-vnlrrHKKELMAHLADGLSalpgirrygptdisllag 309 Pelobacter carb...
ZP_01389159  232 sd----taqpetmpeKFESGTlntPGIAGLKAGVEFIlktgi-dnirqKEIKLVSLLLDGLKqlprvktftaynaesrgg 306 Geobacter sp. F...
YP_902158    238 ss----eeqphilpeGFEAGThnlPGIAGLLAGVEFVlargvdvigrrEREHVAEVARRLAPlpgmaihgp-sfpanrsg 312 Pelobacter prop...
ZP_01775900  232 ss----peqpdqlpeRLESGTintPAIAGLKAGVEFVlttgi-dviraKEELLVNQLLEGLRatphvevyg-plegarga 305 Geobacter bemid...
ZP_01094456  239 lsq--hpqqpdtlpdKYESGNpnvTAILGLQAAVEYLrdrtv-taierEMRERTAQLLEGLAgipsidvfgplsaadrig 315 Blastopirellula...
YP_001319833 233 ay----eyqpdyfpnRLETGTlnvSGIVGLRAALKFIqnegi-ekifeKEKHLVGYALDRLEevrgisiygpkdpnkivg 307 Alkaliphilus me...
YP_001319667 233 ay----eyqpdyfpnKLETGTlnvSGIVGLRSALKFIqkegi-eriyeKEKDLVGYALNRLEeirgisiygpkdpnkivg 307 Alkaliphilus me...
YP_845332    232 ed----aiqpeicpdRYESGTpnlPGIAGLAAGIDYIlssgl-etirdHELGLAVRLEEQLRaipgitvi--spevrgta 304 Syntrophobacter...
ZP_01690598  249 kwtaksayemrtdgvRFENYEynrANRLGLSEAVQYAldlgm-eniwqRIQQLGNLLRQRLVelpnvqvy--dlglvkgg 325 Microscilla mar...
Feature 1                                                                             
NP_354805    336 IFSFELegiHAHDVSMVIDr-rGVAVRAGTHCAMPLLk---rFGVTSTCRASFGLYNtRAEVDRLVEAL 400 Agrobacterium tumefaciens ...
YP_357142    310 ALSFNLsglDPAEIAFWLDnehAICVRAGLHCAPDTHrs-lnTFPRGTVRVSPGYFSrHEDIQALIHAL 377 Pelobacter carbinolicus DS...
ZP_01389159  307 AVSFTVegiDPATIGFHLDadfDISVRVGLHCAPMAHkt-igTYPHGTVRVSPGFFNtDKDIAFLLDAL 374 Geobacter sp. FRC-32
YP_902158    313 LLSFTLagmDASSLAFMLDqrfDIAVRAGLHCAPLAHrs-lgTYPAGTVRVSPGWFTsNDEIAIFCDAV 380 Pelobacter propionicus DSM...
ZP_01775900  306 AVSFNAaghDPAALSFLLDsdyDISVRAGLHCAPDTHrs-igTYPTGTVRVSPGFFNtEADIDFFLKAL 373 Geobacter bemidjiensis Bem
ZP_01094456  316 VVSLNVpgfDPHELASYLDsahHIQVRAGLHCAPLMHqqlgtTDRGGAVRFSVGAFTtAAEIEKVLSAL 384 Blastopirellula marina DSM...
YP_001319833 308 VISFNLqevSGEEVAYILDqeyGVMVRVGLHCAPGPHkm-igKEKEGTVRIGIGYFNtEEDIDLLVNAL 375 Alkaliphilus metalliredige...
YP_001319667 308 VISFNLqgiTGEEVAYTLDqeyGIMVRVGLHCAPGPHri-idKVKEGTVRIGIGYFNeKEDIDLLVNAL 375 Alkaliphilus metalliredige...
YP_845332    305 TVSFTMagiNPADAGHLLDegyDIAVRTGLHCAPLAHrt-fgTFPEGTVRVSPGYATtAADMERLAEAI 372 Syntrophobacter fumaroxida...
ZP_01690598  326 IVSWGIegiPAEFVVEKLRe-vQINTSLILESGTLLDmq--eRELPPLVRSSVHYYNtEEEIEKLCGEL 391 Microscilla marina ATCC 23134

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