2RKB,1P5J


Conserved Protein Domain Family
L-Ser-dehyd

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cd06448: L-Ser-dehyd 
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Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
Statistics
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PSSM-Id: 107209
View PSSM: cd06448
Aligned: 15 rows
Threshold Bit Score: 395.514
Threshold Setting Gi: 171848902
Created: 10-Jul-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
catalyticpyridoxal
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:2RKB_A; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #                                            
2RKB_A      7 VTPLLESWALsqva----gmpVFLKCENVQPSGSFKIRGIGHFCQEMAkkg-------crHLVCSSGgNAGIAAAYAARk 75  human
CAF91636   10 ATPLRQSLPLtkea----gtsVYLKLDSSQPTGSFKIRGIGHLCKTWAerg-------ceRLVCCSGgNAGMAAAYSARq 78  Tetraodon nigrovir...
NP_745074   6 HTPLIESRPLslaa----grnIWLKLDALQPCGSFKLRGVGHACEVHHarg-------arHFVSSSGgNAGLAVAYAGRk 74  Pseudomonas putida...
AAO50766   28 NSPMLESLALsklfk-eenakVWMKVDALQPSGSFKIRGVGLLCNQLLkekks--kneeaHFICSSGgNAGKSVAYAGRk 104 Dictyostelium disc...
P25379      7 KTPLLRQFFPgka-----saqFFLKYECLQPSGSFKSRGIGNLIMKSAiriqkd-gkrspQVFASSGgNAGFAAATACQr 80  baker's yeast
EAK97061    7 TTTFVEVTDKlptk---ppcrVFFKNEYEQPSGSFKLRGMGHLVGQSIdvarkl-gksnvAVFSSSGgNAGLAAAYASQf 82  Candida albicans S...
EAL00695   19 QTSLTEVTNIlptk---ppcrIFFKNELEQPSGSFKLRGIGHLVHKSIenalknhsnktiHVFASSGgNAGLAAAYSAQf 95  Candida albicans S...
XP_387338  14 KTPCIISTQLsrlt----gcnVYLKLENLQPSGSFKTRSISSLMTQAAaaat-----gpvHFYCSSGgNAGLACATSAIs 84  Gibberella zeae PH-1
P17324      8 KTPLIRQVFNngkt----nswFYVKHEILQPGGSFKSRGIGHLIRKSNqqplse-gsgklAVFSSSGgNAGLAAATACRs 82  baker's yeast
NP_986296  75 KTPLMRHVFArqnvrytanpeIMLKYEFFQPSGSFKSRGIGNLIWKEMqkirqn-sslqpHVFASSGgNAGLAAATASRq 153 Eremothecium gossypii
Feature 1                                                                                     
2RKB_A     76 lGIPATIVLPestslQVVQRLQGEGAEVQLTgkv-wdeANLRAQELAKrd-----gWENVPpfdhPLIWKGHASLVQELK 149 human
CAF91636   79 lGVPATIVVPsvtpvMTVERLRDEGATALNE-------SIEYGKQLVAnn----pgWIFISpfddPLIWEGHTSLVKELE 147 Tetraodon nigrovir...
NP_745074  75 lGVPVTVVIPettteRAKQLLHLEDAKVVVQgss-wqeANALAQTLVGp------nDAFIHpfddPLLWAGHASLVDEVA 147 Pseudomonas putida...
AAO50766  105 lNVKTTIVLPntipeATIEKIKDEGANVIVHgti-wdeANTFALELAEkeg---ctDCYIHpfdhPLLWEGHSTMIDEIY 180 Dictyostelium disc...
P25379     81 lSLPCTVVVPtatkkRMVDKIRNTGAQVIVSgaywkeaDTFLKTNVMNkidsqviePIYVHpfdnPDIWEGHSSMIDEIV 160 baker's yeast
EAK97061   83 fGVSCTVVLPesskpTVIEKLKSLGADVIIHgkhwgeaDNYLTDFVIKnldk-tvyPVYCHpfddPLLWEGHSKIITEII 161 Candida albicans S...
EAL00695   96 yKVKCTVVLPiiskpVVQEKLKSYGARIVLFgntineaDQHLKNLMSSidld-siyPVYCHpfnnPLIWNGHSSLVDEVS 174 Candida albicans S...
XP_387338  85 lGHKATIVMPtivspLMKSKLLDLGVEVHQKgknwaecDKYMREELVAnd----psAIYVApfddPRLWDGAATMVDEIR 160 Gibberella zeae PH-1
P17324     83 mALNCSVVVPkttkpRMVKKIQSAGAKVIIHgdhwgeaDEYLRHKLMAqesqhgskTLYVHpfdnETIWEGHSTIVDEII 162 baker's yeast
NP_986296 154 lGLPCTVVVPettrrRMVERIRSTGADVISMgsvlkesDDYLRSELMGnvnlekvaPIYAHpfdnPLIWEGHATMVDEVV 233 Eremothecium gossypii
Feature 1                                                                                     
2RKB_A    150 AVLrt------ppGALVLAVGGGGLLAGVVAGLLEvg--wqHVPIIAMEThGAHCFNAAITAGKLVTlpdi--tsvAKSL 219 human
CAF91636  148 QELre------tpGAIALSVGGGGLLNGVVEGLRRag--wgDVPIVAMETlGAHSLNAAMEAGELVTlpei--tsvATTL 217 Tetraodon nigrovir...
NP_745074 148 EAGlk-------pDAVVLSVGGGGLLSGVVEGLKRng--wgDVPVLAVETeGAASLHAAMQAGHSVEleri--asvATSL 216 Pseudomonas putida...
AAO50766  181 QDVqngv--cekpDVILFSVGGGGMMIGILQGLDRyg--wnDIPIVTVETvGSHSFWKSFQEKQLTKldvsevtsvIKTL 256 Dictyostelium disc...
P25379    161 QDLksqhisvnkvKGIVCSVGGGGLYNGIIQGLERygl-adRIPIVGVETnGCHVFNTSLKIGQPVQfkki--tsiATSL 237 baker's yeast
EAK97061  162 DQKqlpn--fdkvKGVICSVGGGGLYNGIVEGLENh----kEIPVLAIETkQAATFHEAVKEGKVVHlqkv--qtlATSL 233 Candida albicans S...
EAL00695  175 QQLdskd--rkllKGMVCSFGGGGLYNGIYQGMVKnq---iRGDILLIETlQAPTLTQSLEADEVITlksv--nslATSL 247 Candida albicans S...
XP_387338 161 DQLed------rvDGIVCSVGGGSLVNGLMQGIESrpwlgtKPAVLAVETeGADSLNASVLAGEHVTlpem--tsiATSL 232 Gibberella zeae PH-1
P17324    163 EQLkendislprvKALVCSVGGGGLFSGIIKGLDRnhl-aeKIPVVAVETaGCDVLNKSLKKGSPVTlekl--tsvATSL 239 baker's yeast
NP_986296 234 EALhlqgvqlesvKGIVCSVGGGGLYNGIVYGLEKhgl-adSIPVVAVETeGCEVLHRSLLLGRNVSmnp---ksvATSL 309 Eremothecium gossypii
Feature 1                                                                                     
2RKB_A    220 GAKTVAARALECMqvc---kiHSEVVEDTEAVSAVQQLLDDeRMLVEPACGAALAAIYSGLlrrlqaeg--clppsltSV 294 human
CAF91636  218 GLARVSAQTLKLVkeh---avFSEVVTDQEAVKAVERFVDDeKILVEPACGAALAAVYSGVlkklqceg-klakqmggPV 293 Tetraodon nigrovir...
NP_745074 217 GAKRVADQALMCVqqh---pvHSHLVSDRAALEACERFLLDhRVLVEPACGAALAVAYDAKalg-----------alrNV 282 Pseudomonas putida...
AAO50766  257 STRSVCSEAWEISkrf---niKPILVTDRDAVDACLKFVDDeRILVEPSCGATLSVLYSKKlstll-------dinskNI 326 Dictyostelium disc...
P25379    238 GTAVISNQTFEYArky---ntRSVVIEDKDVIETCLKYTHQfNMVIEPACGAALHLGYNTKilenalg---sklaaddIV 311 baker's yeast
EAK97061  234 ASPYLSSKALANYier---ptVLAEIDDLDAVKGVVDVYDHfGYMVEPACGASVASVMHRQdllnkfg----tlspddII 306 Candida albicans S...
EAL00695  248 ACSYTTEQSLKYYkdqslvksQVELIDDIDSLRACVAFEKCfGKVVEPACGAAMAVVYNKIdllyknf---khlqpedIV 324 Candida albicans S...
XP_387338 233 GATRVSEQTWKWSqhps-gmmKSLVVSDADAAISTVRFADDaLQLVEVACGAALAIAYRGDlrdvlgkglsdeewsktNV 311 Gibberella zeae PH-1
P17324    240 ASPYIASFAFESFnky---gcKSVVLSDQDVLATCLRYADDyNFIVEPACGASLHLCYHPEiledile---qkiyeddIV 313 baker's yeast
NP_986296 310 CTSFVTDLTLSYAqky---rtKSVVLDQLAVVQTCLNFAEEsNIVTEPACGAALHLGYHPEilerelg----pltpqdVV 382 Eremothecium gossypii
Feature 1                           
2RKB_A    295 VVIVCGGNNInSRELQALKTHL 316 human
CAF91636  294 VIVVCGGNNIsFGQLQKLKKQL 315 Tetraodon nigroviridis
NP_745074 283 LVVVCGGATAtLEQIQAWLQQA 304 Pseudomonas putida KT2440
AAO50766  327 LTIVCGGNGTsILQLNDLLQTL 348 Dictyostelium discoideum
P25379    312 IIIACGGSSNtIKDLEEALDSM 333 baker's yeast
EAK97061  307 IVVICGGSAInKYIIDEYRSLL 328 Candida albicans SC5314
EAL00695  325 VIVVCGGSCTtGSDLKGFEKMI 346 Candida albicans SC5314
XP_387338 312 VFVVCGGSGItLSMLSEYREKY 333 Gibberella zeae PH-1
P17324    314 IIIACGGSCMtYEDLVKASSTL 335 baker's yeast
NP_986296 383 IVIACGGSTMnLADLKESEDQL 404 Eremothecium gossypii

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