Conserved Protein Domain Family
D-Ser-dehyd

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cd06447: D-Ser-dehyd 
D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive antagonist of beta-alanine in the biosynthetic pathway to pentothenate and coenzyme A. D-serine dehydratase is different from other pyridoxal-5'-phosphate-dependent enzymes in that it catalyzes alpha, beta-elimination reactions on amino acids.
Statistics
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PSSM-Id: 107208
View PSSM: cd06447
Aligned: 11 rows
Threshold Bit Score: 668.283
Threshold Setting Gi: 123533127
Created: 10-Jul-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
catalyticpyridoxal
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:based on similarity to tryptophan synthase beta -like proteins with structure
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
Q63D23     23 VFWVNPNmekyetaikdsplseenvkdAEERLKRFASYIAKVFPETketkgiiESPLLKIPSMkqaleknyeqpilgeLL 102 Bacillus cereus E33L
Q3AFZ5     14 MFWQNPNklsadealarinfsfddifeAQKRLQRFAPLIKKLFPETeng--iiESPLAEIPRMkqeieklyggkihgrLF 91  Carboxydothermus h...
Q46X58     20 LLWVNPRlgqplpasa---psleliaaAEARLARCAPLMAALFPELasshgqvESQLMPATGLqyalge----gaegaWF 92  Ralstonia eutropha...
Q1R901     25 TTWFNPGttslaeglpyvglteqdvqdAHARLSRFAPYLAKAFPETaaaggiiESELVAIPAMqkrlekeyhqpiagqLL 104 Escherichia coli A...
Q8RFX6     22 VGWTNPKemnyteyekklplkdqelkeAEERLKRFAPFIKKVFPETeetygiiESPLEEIFNMqkelekkyhteilgkLY 101 Fusobacterium nucl...
Q04G28     26 IFWKNPNygdelpdld---vnretifqANRRLERFAPYLESVFSDTkrskgiiESPIQRMDSIkdlls------vkgsLL 96  Oenococcus oeni PSU-1
Q03DF6     23 IFWKNLNykkeaelp----vgvehifdAEARFQRFAPYFEVAFPETlpthgilESPLLKMDKMkavlnaeaqnqvkgdLY 98  Pediococcus pentos...
P54555     26 VFWANSGkkegplpra--dewateiaeAEKRMQRFAPYIAEVFPETkgakgiiESPLFEVQHMkgkleaayqqpfpgrWL 103 Bacillus subtilis ...
Q2SHX7     20 IVWLNRNyqnpasapa--tpnvdalyaAEARLKRFAPLLQRLFPELepshgliESSLIQADRLnnrin-----pvgglLF 92  Hahella chejuensis...
Q88TY1     22 IVWQNPDygkradlp----ltradifdAVARWERFAPFLAVAFPETaamngiiESPLLPLEQMkpawealnhqslagqLY 97  Lactobacillus plan...
Q7NUP9     26 CAWFNPAaapaaealpdvglgaadiadASARLRRFAPYISRAFPETaasggiiESPLLPVPAFqqalarrrgrelpgrLW 105 Chromobacterium vi...
Feature 1                  #                                                                  
Q63D23    103 LKCDSHLPisGSIKARGGIYEVLKHAeqlalqhgmlteedd-ysildsdtcreffaTYSIAVGSTGNLGLSIGIMSAkLG 181 Bacillus cereus E33L
Q3AFZ5     92 LKCDNYLKvaGSIKARGGIYEVLKHAetlllenglitledd-yskiaeerfkkffsNYKVAVGSTGNLGLSIGIMAAaLG 170 Carboxydothermus h...
Q46X58     93 IKRDDQLPtaGSIKARGGFHEVLAIAesiaiehgmldpdgd-rrvlateaarklfsQYSVTVGSTGNLGLSIGVMAAaLG 171 Ralstonia eutropha...
Q1R901    105 LKKDSHLPisGSIKARGGIYEVLAHAeklaleaglltledd-yskllspefkqffsQYSIAVGSTGNLGLSIGIMSArIG 183 Escherichia coli A...
Q8RFX6    102 LKMDSHLPvaGSIKARGGVYEVLKHAeelameagllkledd-ysiladkkfkdffsKYKIQVGSTGNLGLSIGITSAaLG 180 Fusobacterium nucl...
Q04G28     97 IKRDDLMPvsGSIKSRGGIYEVLCFAekiaiengfdlkkdn-yqdlrkdkyrklfnQWRIEVASTGNLGLSVGLMAStLG 175 Oenococcus oeni PSU-1
Q03DF6     99 LKADNYLPisGSIKSRGGIYEVLKFAekvamkhgeivygdn-yaklneprfkdlfgQYGIVVGSTGNLGLSIGIVACkLG 177 Pediococcus pentos...
P54555    104 LKCDHELPisGSIKARGGIYEVLKYAenlalqegmlqetdd-yrilqeerftgffsRYSIAVGSTGNLGLSIGIIGAaLG 182 Bacillus subtilis ...
Q2SHX7     93 LKADHDLPvaGSVKARGGIHEVLCFAeslalthgvlkdvdsdyctlasqsardlfsKHTITVGSTGNLGLSIGVIGSaLG 172 Hahella chejuensis...
Q88TY1     98 LKADSQLPisGSIKSRGGIYEVLKFAeqvamahtdltymdd-ysvlatakyhelfaQYGVIVASTGNLALSVGIMAAtFG 176 Lactobacillus plan...
Q7NUP9    106 LKADSHLPisGSIKARGGIYEVLKHAedlalangllqpgdd-yarlaspearslfsRHGIAVGSTGNLGLSIGIMAAkLG 184 Chromobacterium vi...
Feature 1                                                                                     
Q63D23    182 FNVTVHMSADakqWKKDLLRSKGVNVIEYeadyskAVEEGRRQADadpsCYFVDdensHDLFLGYAVAASRLQKQLeelk 261 Bacillus cereus E33L
Q3AFZ5    171 FKVDVHMSHDakeWKKKILRDRGVNVIEYredyskAVEEGRKKAAaeknTYFIDdensRDLFLGYSVAALRLKDQLtelg 250 Carboxydothermus h...
Q46X58    172 FDAVVHMSADakaWKKDRLRKRGVRVVEHegdyaqAVAAGREQALgatrCHFVDdersALLFFGYAAAARHLARQLaeag 251 Ralstonia eutropha...
Q1R901    184 FKVTVHMSADaraWKKAKLRSHGVTVVEYeqdygvAVEEGRKAAQsdpnCFFIDdensRTLFLGYSVAGQRLKAQFaqqg 263 Escherichia coli A...
Q8RFX6    181 FQVIVHMSADakkWKKDMLRSKGVQVIEYesdygkAVEEGRKNSDadpmSYFVDdeksMNLFLGYTVAASRIKKQFdkkg 260 Fusobacterium nucl...
Q04G28    176 FKARIHMSHDatdWKINKLLQNGVEVKIYddnfsnAVAAARVSSQrdpySYFIDdegsKLLFAGYATAGERVKKQLskmq 255 Oenococcus oeni PSU-1
Q03DF6    178 FRTSVHMSSDaaqWKKDMLREKGVNVVEYndnfthAITEARKSAEadpmAYFIDdegsYDLFLGYSVAAVRLQAQLkaqn 257 Pediococcus pentos...
P54555    183 FRVTVHMSADakqWKKDLLRQKGVTVMEYetdyseAVNEGRRQAEqdpfCYFIDdehsRQLFLGYAVAASRLKTQLdcmn 262 Bacillus subtilis ...
Q2SHX7    173 FKTVVHMSSDakeWKMERLRKRGVRVVEHdadygaALEAGRLETIadpcGYFVDdersPNLFMGYAVAAKRLQAQLealn 252 Hahella chejuensis...
Q88TY1    177 FKTTVYMSHDarqWKKDKLRANGVTVEELntdfssVIPVARAAAAkddhTHFVDdegsRDLFLGYAVAGVRLQHQLkvqg 256 Lactobacillus plan...
Q7NUP9    185 FQAAVHMSADarqWKKDKLRAHGVTVVEYqtdysaAVARGREQAArdpdCHFVDdensIHLFLGYAVAAERLKAQLaeag 264 Chromobacterium vi...
Feature 1                                                                                     
Q63D23    262 ivvdeehpLFVYLPCGVGGGPGGVAFGLKLlykdNVHCFFAEPtHSPCMLIGLMTGLHDKiavqdig-idnvtdADGLAV 340 Bacillus cereus E33L
Q3AFZ5    251 ievnkenpLFVYLPCGVGGAPGGISFGLKTifkdDVYCYFVEPtHSPCMLLGLVTQKFSAihvrdfg-ldniteADGLAV 329 Carboxydothermus h...
Q46X58    252 rvvdaahpLFVYLPCGVGGAPGGITYGLKAllgdHVHCFFAEPvASPCVLVQLASGSDDPvsvydig-ldnrtdADGLAV 330 Ralstonia eutropha...
Q1R901    264 rivnadnpLFVYLPCGVGGGPGGVAFGLKLafgdHVHCFFAEPtHSPCMLLGVHTGLHDQisvqdig-idnltaADGLAV 342 Escherichia coli A...
Q8RFX6    261 ivinkehpLIVYIPCGVGGAPGGVAYGLKRifkeNVYIFFVEPvLAPCMLLGMQTGLHEKisvydvg-ihgithADGLAV 339 Fusobacterium nucl...
Q04G28    256 ievskehpLVVYLPAGVGGSPSGVAFGLKLqfadAVIPIFVEPtHMPSVLLGMASGLNHDisvydig-idgktaADGLAV 334 Oenococcus oeni PSU-1
Q03DF6    258 ikvdaehpLFVYLPAGVGGSPSGVAFGLKKiigeNVHPIFAEPtHIPSVSLGMMTGLNDQisvydag-idgvtkADGLAV 336 Pediococcus pentos...
P54555    263 ikpsletpLFVYLPCGVGGGPGGVAFGLKLlygdDVHVFFAEPtHSPCMLLGLYSGLHEKisvqdig-ldnqtaADGLAV 341 Bacillus subtilis ...
Q2SHX7    253 ikvdadhpLFVYLPAGVGGAPGGITYGLKHifndHVHCFFAEPvQSPCMLLGMAGAPGAAptsiyeldlknrtdADGLAV 332 Hahella chejuensis...
Q88TY1    257 ikmdaahpVVVYLPAGVGGSPSGVAFGLKMimgaNIYPVFCEPtHVPSVTLGMMTKLNEKiavqdig-ldgltaADGLAV 335 Lactobacillus plan...
Q7NUP9    265 vrvdadhpLFVYLPCGVGGGPGGVAFGLKQafgdAVHCLFAEPtRSPCMLLGVLTGLHDKvsvqdfg-idnrtvADGLAV 343 Chromobacterium vi...
Feature 1                                                                                     
Q63D23    341 GRPSGFVGKTMepflsGNYTVSdEELYRLLKELADTeNIYLEPSALAGMIGPVKVCkedaylqkq--qlmekvqkgTHIV 418 Bacillus cereus E33L
Q3AFZ5    330 GSPSKLVAEIAnilidGIYTIEdEELFKLLALLKDSeNIKVEPSAAASLKGPLLVNsra---------------naIHIS 394 Carboxydothermus h...
Q46X58    331 GQASHLVSPLMasqlaGVFTVPdDQLYVQLLALKTSmGVEVEPSAAAGIGGPGWLRdspegrayvr-dhgldmrdaTHVI 409 Ralstonia eutropha...
Q1R901    343 GRASGFVGRAMerlldGFYTLSdQTMYDMLSWLAQEeGIRLEPSALAGMAGPQRVCasvsyqqmhg-fsaeqlrnaTHLV 421 Escherichia coli A...
Q8RFX6    340 ARPSGLVGRLMepilsGIFTVDdYKLYDYLRILNETeNKRIEPSSCAAFEGVVSLLkyedskkyienrigkninnvYHVC 419 Fusobacterium nucl...
Q04G28    335 GRPSMIAGKYMkdklfGIATVSdSDMFAYQGMLKKLeNIEVEPSAAVGIRGLIQSKeisei-----------pdsaTHMV 403 Oenococcus oeni PSU-1
Q03DF6    337 GRPSRIAGKMMdtllyGIQTFDdQKMMKNVAELHDSeNVDVEPSAASGFTILDDVQaqleqd--------ypmenaSHIV 408 Pediococcus pentos...
P54555    342 GRPSGFVGKLIepllsGCYTVEdNTLYTLLHMLAVSeDKYLEPSALAGMFGPVQLFsteegrrya---qkykmehaVHVV 418 Bacillus subtilis ...
Q2SHX7    333 GAASQWVCDATrnllsGVYTATdEQLYQQLYLLKDLeNIEVEPSAAIGCLGPAMLTseagqkyldshrlshrmensVHIP 412 Hahella chejuensis...
Q88TY1    336 SRPSRLAGKVMrtlllGTATFEdDDLYRYLTKLVDTeDVIVEPSAAAGFTAIAPIMaqfptl---------agkdvTHIV 406 Lactobacillus plan...
Q7NUP9    344 GRPSGFVGRAMqrlidGYYTVDdDELFRLLAMLEQTeGLRLEPSALAGAPGIARVLeenqgyrqrmgldadrlacaTHLI 423 Chromobacterium vi...
Feature 1               
Q63D23    419 WGTGGSMVPE 428 Bacillus cereus E33L
Q3AFZ5    395 WATGGIFIPE 404 Carboxydothermus hydrogenoformans Z-2901
Q46X58    410 WATGGSLVPR 419 Ralstonia eutropha JMP134
Q1R901    422 WATGGGMVPE 431 Escherichia coli APEC O1
Q8RFX6    420 WATGGKMVPQ 429 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
Q04G28    404 WATGGSMVPK 413 Oenococcus oeni PSU-1
Q03DF6    409 WATGGSMVPK 418 Pediococcus pentosaceus ATCC 25745
P54555    419 WGTGGSMVPK 428 Bacillus subtilis subsp. subtilis str. 168
Q2SHX7    413 WLTGGSFVPD 422 Hahella chejuensis KCTC 2396
Q88TY1    407 WATGGDMMPE 416 Lactobacillus plantarum WCFS1
Q7NUP9    424 WATGGSMVPE 433 Chromobacterium violaceum ATCC 12472

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