1BEU,1V8Z,1X1Q,2DH5,2O2E


Conserved Protein Domain Family
Trp-synth_B

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cd06446: Trp-synth_B 
Click on image for an interactive view with Cn3D
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to glyceraldehyde 3-phosphate and indole at the active site of the alpha subunit. In the beta reaction, indole undergoes a PLP-dependent reaction with L-serine to form L-tryptophan at the active site of the beta subunit. Members of this CD, Trp-synth_B, are found in all three major phylogenetic divisions.
Statistics
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PSSM-Id: 107207
View PSSM: cd06446
Aligned: 50 rows
Threshold Bit Score: 478.569
Threshold Setting Gi: 13878841
Created: 10-Jul-2008
Updated: 3-Jul-2019
Structure
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Program:
Drawing:
Aligned Rows:
 
catalyticpyridoxal
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:
  • Comment:pyridoxal 5'-phosphate (PLP) forms an internal aldimine bond (Schiff base linkage) with the catalytic residue lysine
  • Structure:1V8Z_A; catalytic residue (lys) and cofactor (PLP)
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                       #             
1BEU_B     23 PALNQLEEAFVRAqkdpEFQAQFADLLknyaGRPTALTKCQNITagt--rttLYLKREDLLHgGAHKTNQVLGQALLAKr 100 Salmonella typhimu...
1V8Z_A     17 EPLKELEKAYKRFkddeEFNRQLNYYLktwaGRPTPLYYAKRLTekig-gakIYLKREDLVHgGAHKTNNAIGQALLAKf 95  Pyrococcus furiosus
O59265     57 FAKELIKQEFSEKry-iKIPKEVRELYak-iGRPTPLFRATNLEkilktparIYFKYEGATVtGSHKINTALAQAYYAKk 134 Pyrococcus horikoshii
Q9WZ09     48 FPMSLIEQEVSEErf-iEIPEPVLKEYa--vYRPTPLIRATFLEeylqtparIYYKYEGVSPtGSHKPNTAIAQAYYNKi 124 Thermotoga maritima
Q9Y9H2     51 FPKALIEQEVSREry-iEIPGEVHEAYisfaRRPTPLLRAVNLEralntpaeIYYKYEGVTPtGSHKINTALAQAYYNKl 129 Aeropyrum pernix
Q9HKD2     44 VPAKVLEYEFSGEry-pKIPDEILERYmq-vGRPTPIIRAKKLEellggnlkIFLKMESYTYsGSHKINSALAHVFFARe 121 Thermoplasma acido...
P50383     44 LPKEVLRQQFTIEry-iKIPEEVRDRYls-iGRPTPLFRAKRLEeylktparIYFKYEGATPtGSHKINTAIPQAYFAKe 121 Sulfolobus solfata...
NP_661098  50 FPMNLIEQEVSTErw-iDIPEEILGILk--lWRPSPLYRARRLEaalgtpakIYYKNEGVSPaGSHKPNTAVAQAWYNRe 126 Chlorobium tepidum...
Q8TL44     59 FPKALIMQEMSSDry-iDIPEEVLDVYr--lWRPSPLFRAHQLEkvlkspakIYYKYEGVSPaGSHKTNTSIAQAYYNMk 135 Methanosarcina ace...
Q8ZV44     36 LPSALIDQEFTAErw-vSIPEEVREAYrr-vGRPTPLFRAEGLEkalgtgvrIYYKYEGVLPvGSHKLNTALAQAYYAKa 113 Pyrobaculum aeroph...
Feature 1                                                                                     
1BEU_B    101 MGKSEIIAETGAGQHGVASALASallgLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHSGs---------------aT 165 Salmonella typhimu...
1V8Z_A     96 MGKTRLIAETGAGQHGVATAMAGallgMKVDIYMGAEDVERQKMNVFRMKLLGANVIPVNSGs---------------rT 160 Pyrococcus furiosus
O59265    135 EGIKRLVTETGAGQWGTALSLAGaligLKVRVYMTRASYYQKPYRKILMEIYGAEVFPSPSEntevgkrflredpnhpgS 214 Pyrococcus horikoshii
Q9WZ09    125 EGVKRLVTETGAGQWGSALSYAGakfgLEVKVFMVKVSYQQKPMRKYMMNLFGGKVTPSPSEetnfgrkilsedpdnpgS 204 Thermotoga maritima
Q9Y9H2    130 EGVERLVTETGAGQWGSALSAAGayfgVKVRVYMVRVSYLQKPYRRTLMELYGAEVYPSPSDktefgrkllaenpnhpgS 209 Aeropyrum pernix
Q9HKD2    122 EGAKFVSTETGAGQWGSAVALASalfhMESHIFMVRTSFYAKPYRKYMMYMYGAHPHPSPSEfteygrevlkrmpdtpgS 201 Thermoplasma acido...
P50383    122 EGIEHVVTETGAGQWGTAVALAAsmynMKSTIFMVKVSYEQKPMRRSIMQLYGANVYASPTNlteygrkiletnpqhpgS 201 Sulfolobus solfata...
NP_661098 127 FGIKYLTTETGAGQWGSALAMSCkligIECKVFMVRISFDQKPFRKIMMNTWGAECIPSPSPltavgrrileedpdtpgS 206 Chlorobium tepidum...
Q8TL44    136 EGTERLTTETGAGQWGSALSLACnyfdLECKVYMVRSSFYQKPYRKSLITLWGGNVVPSPSPdtefgrkilqeqpdtpgS 215 Methanosarcina ace...
Q8ZV44    114 DGAVEVATETGAGQWGMAVSLAAalfgLRAVVFMTRSSYNSKRQRLTFMRAYGAVVYPSPSDvteagrrh--yrpdhpgS 191 Pyrobaculum aeroph...
Feature 1                                                                                     
1BEU_B    166 LKDACNEALRDWSGSyeTAHYMLGTAagphpypTIVREFQRMIGEETKAQILDkegrlPDAVIACVGGGSNAIGMFADFI 245 Salmonella typhimu...
1V8Z_A    161 LKDAINEALRDWVATfeYTHYLIGSVvgphpypTIVRDFQSVIGREAKAQILEaegqlPDVIVACVGGGSNAMGIFYPFV 240 Pyrococcus furiosus
O59265    215 LGIAISEAIEDVLSDe-KARYSLGSVl------NHVLMHQTVIGLEAKKQVKEfe--ePDVIIGCVGGGSNFAGLSYPFI 285 Pyrococcus horikoshii
Q9WZ09    205 LGIAISEALEVAVSDp-NTKYSLGSVl------NHVLLHQTVIGLEIKKQLELig-ekPDILLGCHGGGSNFGGTILPFV 276 Thermotoga maritima
Q9Y9H2    210 LGIAISEAIEDVINSggNAKYSLGSVl------NHVLLHQTVIGLEAEKQFREag-vyPDIMIGAVGGGSNFAGFTYPFI 282 Aeropyrum pernix
Q9HKD2    202 LGLAISEAIHYALDN--GGKYIAGSVi------NSDILFKTIAGMEAKKQMEMag-edPDYIVGVVGGGSNYAALAFPFL 272 Thermoplasma acido...
P50383    202 LGIAMSEAIEYALKN--EFRYLVGSVl------DVVLLHQSVIGQETITQLDLlg-edADILIGCVGGGSNFGGFTYPFI 272 Sulfolobus solfata...
NP_661098 207 LGIAISEAIEQAVERd-DTRYALGSVl------NHVMLHQTIIGLEARKQFDKig-ryPDIVIGCAGGGSNFAGISFPFL 278 Chlorobium tepidum...
Q8TL44    216 LGIAISEAVEDAIAHe-NTKYSLGSVl------NHVVLHQTVIGAECKQQLAQve-eyPDVVIGCCGGGSNLGGIGLEFI 287 Methanosarcina ace...
Q8ZV44    192 LGIAISEAVEYVLSGe-RRKYLPGSVm------EFVLLHQTVIGLEAVRQLPEe----PDVAVACVGGGSNFAGFTYPMI 260 Pyrobaculum aeroph...
Feature 1                                                                                     
1BEU_B    246 NDt-------sVGLIGVEPGGhgietgehgaplkhgrvgiyfGMKAPMMqtadgQIEESYSISAGLDFPsvGPQHAYLNS 318 Salmonella typhimu...
1V8Z_A    241 NDk-------kVKLVGVEAGGkglesgkhsaslnagqvgvfhGMLSYFLqdeegQIKPTHSIAPGLDYPgvGPEHAYLKK 313 Pyrococcus furiosus
O59265    286 KDvldg--kaeYEFIAVEPRAvptmtkgvytydygdsagltpKIKMYTLg---hTYYVPPIHAGGLRYHglAPTLSVLMN 360 Pyrococcus horikoshii
Q9WZ09    277 PDkls---grdIRFVACEPAAcpsltkgnydydfgdtagltpLLKMYTLg---kDFIPPKIHAGGLRYHgsAPIIARLVK 350 Thermotoga maritima
Q9Y9H2    283 RHrlkg--sssTRFIAVEPKAspsmtrgvytydygdtagltpLLKMHTLg---hTYQVPPIHAGGLRYHgvAPTLSVLLK 357 Aeropyrum pernix
Q9HKD2    273 ADelss-gkirRTYIASGSKEvpkmtegeyrydypdtgkvlpLLKMYTIg---yDFIPPAVYAGGLRYHavAPTLSLLMN 348 Thermoplasma acido...
P50383    273 GNkk------gKRYIAVSSAEipkfskgeykydfpdsagllpLVKMITLg---kDYVPPPIYAGGLRYHgvAPTLSLLTK 343 Sulfolobus solfata...
NP_661098 279 YDkih---gkdVQVIATEPEAcptltrapyaydsgdvammtpLLPMHSLg---hTFIPPAIHAGGLRYHgmAPLVSHTKQ 352 Chlorobium tepidum...
Q8TL44    288 KDrleg--khsARVVAVEPSAcpsltkgeyrydfgdtaemtpLLKMYTLg---hKHVPPAIHAGGLRYHgdSPIISKLCS 362 Methanosarcina ace...
Q8ZV44    261 GMklrgegfgrTRFVAVESEAapkltrgeykydfpdavgvlpMLKMYTLg---hDYVPPAIHAAGLRYHgaAPSLSLLRK 337 Pyrobaculum aeroph...
Feature 1                                                                            
1BEU_B    319 iGRADYVSITDDEALEAFKTLCRhEGIIPALESSHALAHALKMmreqp--ekeqLLVVNLSGRGDKDIFTV 387 Salmonella typhimurium
1V8Z_A    314 iQRAEYVTVTDEEALKAFHELSRtEGIIPALESAHAVAYAMKLakem---srdeIIIVNLSGRGDKDLDIV 381 Pyrococcus furiosus
O59265    361 hGIVKPMAYHQTEVFEAAVLFAKaEGIVPAPESAHAVRAVIDKaleakrkgeetVILFNLSGHGLLDLKGY 431 Pyrococcus horikoshii
Q9WZ09    351 eGLVEAQAFDQDETFEAAKIFAKlEGIIPAPESAHAIAGAIREakkakeegkerVIVFTLSGHGLLDLTAY 421 Thermotoga maritima
Q9Y9H2    358 hGIVEARAYHQREVFRAAHMFAKaEGIVPAPESAHAVKAAIDEaikardegrrvVIAFNLSGHGLLDLQGY 428 Aeropyrum pernix
Q9HKD2    349 kGIVSARDYDQEEAFKWARIFSEtEGYIPAPETSHALPILKEIadknr--gekkTVLVSFSGHGLLDLGNY 417 Thermoplasma acidophilum DS...
P50383    344 eGIVEWREYNEREIFEAAKIFIEnQGIVPAPESAHAIRAVVDEaiearknnerkVIVFNLSGHGLLDLSNY 414 Sulfolobus solfataricus
NP_661098 353 lGLIEATALPQTECYEAALLFAHtEGFIPAPETSHAIAQTIREakqakeegkekVILMNWSGHGLMDLQGY 423 Chlorobium tepidum TLS
Q8TL44    363 eGLMEAVSYDQQEVFDAAVQFARtEGIVPAPESSHAIRCAIDEalaakqtgeekTILFNLSGHGHFDMSSY 433 Methanosarcina acetivorans
Q8ZV44    338 lGIVEAVAYPQEEVMRAALLFARtEGIVPAPESAHAIKAAVDLakkl---prgsVIAFNLSGHGLLDSDAY 405 Pyrobaculum aerophilum str....

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