Conserved Protein Domain Family
GlcNAc-1-P_transferase

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cd06436: GlcNAc-1-P_transferase 
N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine.
N-acetyl-glucosamine transferase is responsible for the synthesis of bacteria Poly-beta-1,6-N-acetyl-D-glucosamine (PGA). Poly-beta-1,6-N-acetyl-D-glucosamine is a homopolymer that serves as an adhesion for the maintenance of biofilm structural stability in diverse eubacteria. N-acetyl-glucosamine transferase is the product of gene pgaC. Genetic analysis indicated that all four genes of the pgaABCD locus were required for the PGA production, pgaC being a glycosyltransferase.
Statistics
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PSSM-Id: 133058
View PSSM: cd06436
Aligned: 7 rows
Threshold Bit Score: 276.957
Threshold Setting Gi: 94984622
Created: 9-Jun-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DXD motif
Feature 1:DXD motif
Evidence:
  • Comment:DXD motif in the catalytic site could be in binding the metal ion that is used to corordinate the phosphates of the NDP-sugar in the active site.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
YP_062911    45 FFVPCRDEAAVIERTVAAARrdf-pavHVWVVDDHSDDDTgrivea-iarrdSRVHLVTRRRPEARTGKGDALNAAydal 122 Leifsonia xyli s...
YP_603986    46 FLIPALNEAQVIEATVHNLRrvs-pnsRVAVIDDDSDDATavlvsa-laasdPNVLLLRRVAPEARQGKGRALNWAatql 123 Deinococcus geot...
NP_267421   439 VLIPCLNEELVIQTTLKSILkndyenlVVTVIDDASDDRSlekis---eiqdSRLNVLRRIKPNAQKGKGTALNWAyyqi 515 Lactococcus lact...
YP_062323    64 VMIPCLNEEAVIGRTVATLVgnt-rttTTIVIDDGSEDTTaqiar---eeggEKVIVLRRELPNARQGKGVALNQAyeli 139 Leifsonia xyli s...
AAF68964     77 FLLACLNEEKVLAESLARITalparntLALVIDDASDDRTadiaraacaahpGTVHLLRRQLPNARKGKGAALNAGiahl 156 Streptomyces ver...
ZP_03074081  56 VIVPCFNEAAVIQRTIKCLLrfk--qfAIVVVDDASSDDSvgqik---qitnSRVHLLRRHLPNAHTGKGDVLNFAldyi 130 Lactobacillus re...
YP_645356    43 LLVPALNEERVISRTLSSLLrlr-gnfLVLVIDDASEDGTvaavr--pflenPRVRLLRQPPEEARRGKGHVLNAGvgai 119 Rubrobacter xyla...
Feature 1                          ###                                                          
YP_062911   123 nafl-padadrerIIVMVLDADGelsaralammasaevfldpgVGGAQVVVWMKNrherrpkpghgwlgnlfgRFLVKLQ 201 Leifsonia xyli s...
YP_603986   124 lqrlraegadlsrEVFAVIDADGrigpellee--arqalgdpqVMGAQARVRIRQsvgrlc------pqnvigRMLEQQQ 195 Deinococcus geot...
NP_267421   516 seqiqeagiapedVLIAIIDADTkldnnyfekv-nmafnhdakLTGLQSKVRVAN------------------LIKDASQ 576 Lactococcus lact...
YP_062323   140 kklvtergenperVLILVMDADGrlsngafsh--ilplfedpqVAGVQLAVRIRNra---------------tNFLTWFQ 202 Leifsonia xyli s...
AAF68964    157 rssglldgrdprdVIVCVVDADGrldphvvqa--vdpyfdnprTGGTQIGVRMYNrh---------------kGLLARLQ 219 Streptomyces ver...
ZP_03074081 131 cqitirqrvpfekVIIGVVDADAqlaenalqr--lnayfssprTNITQMRVKMYPhf---------------kNWLQILQ 193 Lactobacillus re...
YP_645356   120 rrmriseyfgaenIIVTVFDADArvepgflda--vapcfadprVAGVQSAVRMYNad---------------aNLLTFWQ 182 Rubrobacter xyla...
Feature 1                                                              
YP_062911   202 DIEFRtiiaamQSLRARTGTVGLGGNGQFARLSVLDlir-ashDRPWHG-ALLED 254 Leifsonia xyli subsp. xyli str. CTCB07
YP_603986   196 DVEFFitr-hlQVLRSRWHTVALCGNGQFMRASYVAgqf-argLEPWPD-VLLED 247 Deinococcus geothermalis DSM 11300
NP_267421   577 DLEFSeiinatQMFRTLTNTVAFGGNGQFCKLSTLQal----nEDPWTD-SLVED 626 Lactococcus lactis subsp. lactis Il1403
YP_062323   203 DFQFWamsavtQFGRAKTGTVSLGGNGQFTRLSALLal----kNQPWSD-SLTED 252 Leifsonia xyli subsp. xyli str. CTCB07
AAF68964    220 DMEFViygdifQSARRYIGSVGMGGNGQFMRLAALDtllgpdgSGPWSD-SLTED 273 Streptomyces verticillus
ZP_03074081 194 DIEFFsvnhmaQIMRMYTKTVGLSGNGQFFRLAPIIdk---igAHPWGN-ALLDD 244 Lactobacillus reuteri 100-23
YP_645356   183 NLEFAiwgrvmCRAKNLLGSATLGGNGQCVRLSALEgl----gEEPWQAaSLTED 233 Rubrobacter xylanophilus DSM 9941

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