Conserved Protein Domain Family
GT2_HAS

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cd06434: GT2_HAS 
Hyaluronan synthases catalyze polymerization of hyaluronan.
Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.
Statistics
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PSSM-Id: 133056
View PSSM: cd06434
Aligned: 24 rows
Threshold Bit Score: 253.331
Threshold Setting Gi: 46122895
Created: 12-Nov-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DXD motif
Feature 1:DXD motif
Evidence:
  • Comment:DXD motif in the catalytic site could be in binding the metal ion that is used to corordinate the phosphates of the NDP-sugar in the active site.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
XP_380878     76 DVTVVIPTIHNafEELRPSLESILace--paELILVTTHDKRkelqkl-------------------------------- 121 Gibberella zeae...
YP_001511506  51 STSVIVPSFREdpDVLIRCLETWLsqq--pdEIIIIPDVEDTeliarl-------------------------------- 96  Frankia sp. EAN...
NP_394332     37 DVTIVMPVYKEdpIVFEESVASASqq---gsQVYVLGDDCDEpyksi--------------------------------- 80  Thermoplasma ac...
YP_023746     45 DVTAVIPVYNEnpEIFESVIKSLInq---cgSLIVVGDSSYEpyrsi--------------------------------- 88  Picrophilus tor...
ZP_03181506   51 TTSVIIPVVDEpeDLFRAVLQRIIqqq--ptEIIVVVNGRRNpdler--------------------------------- 95  Streptomyces cl...
ZP_02085138   54 FTSVLLPVVDEplDLFYSVLMKIArqn--psEIIVVINGPKNeglenlcvd----------------------------- 102 Clostridium bol...
NP_342746     63 KVSAIVPEYGEnlEIFEKCLRSVAknk--pdEIIVVHDDKRKevvdi--------------------------------- 107 Sulfolobus solf...
NP_005319     84 TVALCIAAYQEdpDYLRKCLQSVKrltypgiKVVMVIDGNSEddlymmdifsevmgrdksatyiwknnfhekgpgetdes 163 human
NP_990137     84 TVALCIAAYQEdpDYLRKCLLSVKrltypgiKVVMVIDGNSEddvymmdifteimgrdksatyiwsnnfhdkgpgetees 163 chicken
NP_705936     84 SLALCIAAYQEdpNYLRKCLISVKrltypgiKVIMVIDGNNDddcymmeifreimgrdkaatyiwksnyhhrgpeetees 163 zebrafish
Feature 1                                                        ###                             
XP_380878    122 --------adslvfPKVRVLDTPIANKRLQVCEAlpkv--etpITIMADDDVTWPStlmPWILAPFe-DPEIGGVGTCQR 190 Gibberella zeae...
YP_001511506  97 ---------aqradPTVRVIPFVHEGKRSALGVGlsaa--trdIVVLCDSDTAWEPgllAAVQMPFv-DPQVGGVGTRQN 164 Frankia sp. EAN...
NP_394332     81 ----------aekhGCAFIRVSPHRGKRGILSYSmkiv--ktpLVMFLDSDTVLDHgavEDMIKYL--EEDVGGVGTNIS 146 Thermoplasma ac...
YP_023746     89 ----------tekfNGRFIYLKKHSGKRLALVEGiknv--ktrYVLFVDSDTLVPEkatLSMLSKF--KRNVGGVGVNIN 154 Picrophilus tor...
ZP_03181506   96 ----------icsdLDVMWIWTETPGKRNALRVGlgha--tgeIAVLVDSDTVWTRntlSELVKPFk-DAKVGGVTTRQR 162 Streptomyces cl...
ZP_02085138  103 -----fnrnlpicfTPVQHYYTPVAGKRNGIRVAmehinpnsdITVLVDSDTVWTEdtlSELLKPFacDQKIGGVTTRQK 177 Clostridium bol...
NP_342746    108 ----------skkyGAKVISLSRRVGKRGALIIGwlna--igdIIVQLDSDTIMEDntiNEIVKPFa-DPKVAGVQGRPV 174 Sulfolobus solf...
NP_005319    164 hkessqhvtqlvlsNKSICIMQKWGGKREVMYTAfralgrsvdYVQVCDSDTMLDPassVEMVKVLeeDPMVGGVGGDVQ 243 human
NP_990137    164 hresmqhvsqlvlsNKSVCIMQKWGGKREVMYTAfkalgeawnYVQVCDSDTMLDPassVEMVKVLeeDPMVGGVGGDVQ 243 chicken
NP_705936    164 yatslqhvshlvlnNKCVCIMQKWGGKREVMYTAfkalgrsvdYVQVCDSDTMLDPassVEMVKVLeeDPNVGGVGGDVQ 243 zebrafish
Feature 1                                                                                        
XP_380878    191 VRRehdgswstKAWNWLGAAYIERrnfeis-athnidGGTSCMSGRTGAYRSEILsshdflhgfknekwrkwilNADDDN 269 Gibberella zeae...
YP_001511506 165 VYEpr-----sSVWRRVANWLVDIryldyv-paqgrvGAVACLSGRTAAYRRSAIlpvlhnleh--efflgrrcIAGDDG 236 Frankia sp. EAN...
NP_394332    147 IFRn-------GHPVSYTSEFVERvrevif-ksmsrkSSVMVLDGRCALYRTNLVmpfltsrefqdntvmgkksVLGDDR 218 Thermoplasma ac...
YP_023746    155 IKNd-------GSGIAYASEFIERvrevif-ramsyhGSILVADGRCAMYLTEAVrplllsndfmnkkilgkrtMLGDDI 226 Picrophilus tor...
ZP_03181506  163 ILEp------gRSVLTRWADWLESvrcqyslpamsvmGTVGCLPGRTIAFRKQILddcmedfls--erflgvflEVSDDR 234 Streptomyces cl...
ZP_02085138  178 ILDp------dRKLVTMFANLLEEiraegtmkamsvtGKVGCLPGRTIAFRTQILidvmydfmn--etfmgfhkEVSDDR 249 Clostridium bol...
NP_342746    175 LFRtd----grIPYLFGQIIEYSRdivv-----ralnGTLNVIDGKIAAYRRSYLletirhfnh--etygkrklIAADDK 243 Sulfolobus solf...
NP_005319    244 ILNky-----dSWISFLSSVRYWMafnier-acqsyfGCVQCISGPLGMYRNSLLhefvedwyn--qefmgnqcSFGDDR 315 human
NP_990137    244 ILNky-----dSWISFLSSVRYWMafnier-acqsyfGCVQCISGPLGMYRNSLLhefvedwyn--qefmgsqcSFGDDR 315 chicken
NP_705936    244 ILNky-----eSWVSFLSSVRYWMafnier-acqsyfGCVQCISGPLGMYRNSLLhefledwyd--qtfmgshcSFGDDR 315 zebrafish
Feature 1                                                       
XP_380878    270 FVTRWlvshQWKTWIQYEKeceiettlensTKFLYQCSRWARSNWRS 316 Gibberella zeae PH-1
YP_001511506 237 RLTWLvlasGYKTMHQHTAhamsm-fpdnlRAFIKQRVRWSRNSYRT 282 Frankia sp. EAN1pec
NP_394332    219 QLTSYiirsGYRAVKDYDVyarty-qyssfKKFFKQQIRWGRVGWTY 264 Thermoplasma acidophilum DSM 1728
YP_023746    227 QITSYliksGYKVVKDYNVtvqte-pqgdfKRFFRQQIRWSRNGWYY 272 Picrophilus torridus DSM 9790
ZP_03181506  235 TLTNYtlraGYRTVYQSSSlvytd-aplelGKLARQQYRWARGSQYN 280 Streptomyces clavuligerus ATCC 27064
ZP_02085138  250 SLTNLtlrkGYKTVMQDTSviytd-aptewKKFIRQQLRWSEGSQYN 295 Clostridium bolteae ATCC BAA-613
NP_342746    244 ALTYYanmnGYKTVYQATAvaksa-aqptfLKFLNQQLRWARSGYLY 289 Sulfolobus solfataricus P2
NP_005319    316 HLTNRvlslGYATKYTARSkclte-tpieyLRWLNQQTRWSKSYFRE 361 human
NP_990137    316 HLTNRvlslGYATKYTARSkclte-tpieyLRWLNQQTRWSKSYFRE 361 chicken
NP_705936    316 HLTNRvlslGYATKYTARSkclte-tpityLRWLNQQTRWSKSYFRE 361 zebrafish

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