Conserved Protein Domain Family
GT_2_WfgS_like

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cd06433: GT_2_WfgS_like 
WfgS and WfeV are involved in O-antigen biosynthesis.
Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.
Statistics
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PSSM-Id: 133055
View PSSM: cd06433
Aligned: 107 rows
Threshold Bit Score: 179.663
Threshold Setting Gi: 22298559
Created: 18-Nov-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
metal binding
Feature 1:metal binding site
Evidence:
  • Comment:based on homology to other members of the superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                            #                                            
YP_001528412   20 SIITVVLNGadTLERAIKSVVSQTFrd--fEYIIIDGGSTDGTLDIIRryesh------ltcwiSEPDKGLYDAMNKGVA 91   Desulfococcus...
EDZ68182      420 TIVTPVLNGaqFIEATLRSVLVQEYpa--lEFIIVDGGSTDDTLSIIDsvqnssdfkdriscviSEPDGGMYDAIAKGFS 497  Nitrosococcus...
AAS83011       28 TIITPCLNRaaLVAEAVESVLAQDGvt--vEHIVVDGGSTDGTLEVLAryph--------lrvlTGPDRGVYDAINRGLG 97   Azospirillum ...
YP_001997407   11 SIITPVFNGevFIENCLKNVIEQKCpf--aEHLIMDGGSKDKTVEILKtysqkh----phihfiSEKDNGQSDAMNKGIK 84   Chloroherpeto...
YP_677476      12 SIITPSYNQgaFIERTIKSVLEQNYsn--lEYIIVDGGSTDNTVEIIKkyqdk------ihywiSERDKGTYEANNKALE 83   Cytophaga hut...
ZP_01035650   165 TVLIATFNAsaDLVATLQSILVQNRtd--iECIIVDGGSRDHTLDIAAawphv------vthcfSHPDKGLYDALNKGLA 236  Roseovarius s...
YP_589969       7 SIVTPSLNQgpFLRECLKSVAKQGIsv--iEHIVMDGDSTDDSMETLKafeaecr---yplrwqSKRDRGQSDAINKGFK 81   Acidobacteria...
YP_002135509    4 TILTPTLNAerFLPECLQSIRMQSYpasriQHLVLDGHSSDGTVALARasga---------evsVQRDGGLYEAMNRGIR 74   Anaeromyxobac...
ZP_03127701    10 VLAVPVFNGerFLAETLASLNEQGDd---vRWWMQDGASKDGTVEIARrfvrp------cdkivSEPDSGQPDALNRAFQ 80   Chthoniobacte...
YP_001878182    8 SIITPSYNYarYVRECIESVKNQEGat--fEHIIQDAGSTDGTLDILHsyph--------lklhVEKDSGMSEGINRGFR 77   Akkermansia m...
Feature 1                                                                                         
YP_001528412   92 LSKGEWVYFLGADDYLldgftsaa---arlkdgtTVYYGNvyrpvadriydg----------------rfsfyklacrnI 152  Desulfococcus...
EDZ68182      498 RATGEILGYLNADDLLeggalaavgsyfsrhpkvAVIYHEdtvlvngwkypnvrq----------pkgintvdllnkhiL 567  Nitrosococcus...
AAS83011       98 IARGSVVGHLNSDDLLlpgaltavaralatapeaDAACGGatvvetgsgldgterpreacgyddpamkrlrpfdlcrgvP 177  Azospirillum ...
YP_001997407   85 MAKGDIISFLNVDDFYepnalndaaaiidkmtepGLLVGNckvwisedkiqrvnkpk-----hlklrdlllgveinehpI 159  Chloroherpeto...
YP_677476      84 KVTGDFWCVVNSDDLLaegalekiaahiqrnpesKWFAGGidyidendavtghfip-------ekpeavngftfidgcwI 156  Cytophaga hut...
ZP_01035650   237 VARGTLIGIVGAGDCYlpgaldrv--afahysepADVFGGqtierapdgqtrkrk----------depwglnafvsggpV 304  Roseovarius s...
YP_589969      82 EAKGEIIGWLNADDRYrpgafsavldafrkhpetDVLYGDytwidadgetvqqrre--------igfspfvllyhrvlyI 153  Acidobacteria...
YP_002135509   75 LAGGDVIGWLNGDDAYepgaiaavvdafrqnptaEIVVGDhrmagpegsrlirgra--------ealarlragkrrgawV 146  Anaeromyxobac...
ZP_03127701    81 QMGGEIIGFLNADDTLlpgtarkvldyfaahpdvDLVCGEiewidehsnvtgrhagri---hslaevldiygvwwanrqW 157  Chthoniobacte...
YP_001878182   78 KARGKWVMWLNTDDRLlpgalaavkafadsrpdaDIVYGAwnfigpdgeiqramk---------alpyslnmhiwygtyL 148  Akkermansia m...
Feature 1                                    # #                                 
YP_001528412  153 CHQSIFYPRCVWkkfs--ynlkYPVFADYDLNLRCFVddgiqf-kyipdtIAVFTDEGGLSPR 212  Desulfococcus oleovorans Hxd3
EDZ68182      568 FQDGVFFRREAYqtigg-lrrdLKLAGDYDLWLRLSArfkfir-rsghvsCFRIRRGQFSENM 628  Nitrosococcus oceani C-27
AAS83011      178 MINARFFRRSLYervgg-ydpsYRYAGDREFLIRAWTagmktv--pvaerVYLYRQHDGSMTI 237  Azospirillum brasilense
YP_001997407  160 NPSAYFYHKSLHekigy-ykidEHFAMDIDFIYRAVQyahvk---yvdkiWGNFRSYNDTKTV 218  Chloroherpeton thalassium ATCC...
YP_677476     157 SHPAVFLSSDLIntig---kfeKYHLMDLNYWLRMELqgyspf--ivhtsLAALRLHKDSKSA 214  Cytophaga hutchinsonii ATCC 33406
ZP_01035650   305 GHNGMFATSKAYeqigs-fgyvYPMAEDTRWMHRAIHagcsft--yipepVVLFPLTGMSNNN 364  Roseovarius sp. 217
YP_589969     154 QTTAMFFHRRVLdagyc-ldesLHYAMDFEFFVRLSAsrhrfl--hvpvfLGDFRFQPKSKTT 213  Acidobacteria bacterium Ellin345
YP_002135509  147 VPIATFFRAATLrglgp-yrseYRYCADLDLWMRAAArpsppevarvdtvIGSFRVHAGSLSS 208  Anaeromyxobacter sp. K
ZP_03127701   158 VQPEVFFRRSLWekagl-fdpkWNLVFDYEFWIRCFRagarva--hlsepLTRFRIHGAQKSA 217  Chthoniobacter flavus Ellin428
YP_001878182  149 ASTALFLRRSTTieegfllderFHYDMDGEYYARLGRagkkfv--hynrlLADFRWHGDNLSA 209  Akkermansia muciniphila ATCC B...

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