Conserved Protein Domain Family
M1P_guanylylT_A_like_N

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cd06428: M1P_guanylylT_A_like_N 
N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase.
N-terminal domain of the M1P-guanylyltransferase A-isoform like proteins: The proteins of this family are likely to be a isoform of GDP-mannose pyrophosphorylase. Their sequences are highly conserved with mannose-1-phosphate guanyltransferase, but generally about 40-60 bases longer. GDP-mannose pyrophosphorylase (GTP: alpha-d-mannose-1-phosphate guanyltransferase) catalyzes the formation of GDP-d-mannose from GTP and alpha-d-mannose-1-Phosphate. It contains an N-terminal catalytic domain that resembles a dinucleotide-binding Rossmann fold and a C-terminal LbH fold domain. GDP-d-mannose is the activated form of mannose for formation of cell wall lipoarabinomannan and various mannose-containing glycolipids and polysaccharides. The function of GDP-mannose pyrophosphorylase is essential for cell wall integrity, morphogenesis and viability. Repression of GDP-mannose pyrophosphorylase in yeast leads to phenotypes including cell lysis, defective cell wall, and failure of polarized growth and cell separation.
Statistics
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PSSM-Id: 133050
View PSSM: cd06428
Aligned: 18 rows
Threshold Bit Score: 342.697
Threshold Setting Gi: 50422827
Created: 6-Jun-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative substrate binding site
Evidence:
  • Comment:Predicted GDP-glucose binding site based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ####               #                                                         
BAD96671       4 AVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAqvpgmqEILLICFYqPDEPLTQFleaa---qqeFNLPV 80  human
XP_782147      4 AVILIGGPQKGTRFRPLSLELPKPLFPVAGFPIIYHHIEACSklpdiqDVLLIGTYqPSDSLNRFitsa---qreFKFNI 80  purple urchin
XP_001636846   4 VVILIGGPMKGTRFRPLSLELPKPLFPVAGFPIIHHHIEACKkipdlkEVILIGFYqSSEPLSKFitsa---qqeFGLQI 80  starlet sea ane...
AAL89870       4 AVILIGGPQKGTRFRPLSLDTPKPLFPLAGRPLIAHHIEACAqlpdirEILIIGYY-PQTQMEGFvgdmqalyssSNINI 82  fruit fly
EAL19591      30 GVILVGGPSKGTRMRPLTLDCPKPLLPVAGKPMIWHPLQALSkvpdltEVIIIGFY-DDSQMAAFvkea--krefPNIAI 106 Cryptococcus ne...
XP_503968      5 ALILVGGGTRGTRFRPLSLDTPKVLFPVGGKPILSHAVDAVAslkdvkEVLLVGFY-EDSVFSQFiadt--nkqyPNLSI 81  Yarrowia lipoly...
XP_958781     22 AVILVGGASRGTRFRPLSLDVPKPLFDVAGHPIIWHCLTAIAkvpsihEVYLIGYY-DESVFRDFikda--vhefPQLTI 98  Neurospora cras...
CAA18655       5 AVILVGGPSRGTRFRPLSFDVPKPLFKIGGREMIYHHLAALSkiesvkDVFLVGFY-DESVFKDFineva-shfpSFNRI 82  fission yeast
AAF60647       5 AVVLVGGPQKGTRFRPLSLQLPKPLFPIAGVPLIEHHIDQLCqlsglsEILLLGFF-PSDVFTDFisrc---qqtYRVSI 80  nematode
XP_002119603  10 AIILIGGPEKGTRFRPLSLDVPKPLFPVAGFPMVQHHIEACCqvpeikEILLIGFFpLSDELKSFleya---kkqFTPSI 86  Ciona intestinalis
Feature 1                                          ###                                           
BAD96671      81 RYLQEFAPLGTGGGLYHFRDQILags-peaFFVLNADVCSDFPLSAMLEAHRRqr--hPFLLLGTtanrtqslnYGCIVE 157 human
XP_782147     81 RYLQEYTALGTAGGLYHFRDQILsgq-pkgFLVFNGDVCCKFPLAELWDFHEKvsqddHYTMLSTeatrdqslsYGCLVE 159 purple urchin
XP_001636846  81 RYLQEYQPLGTVGGIYHFRDQISfgn-pdgLVVINADISCDFPFQELLEFHQQhp--gKHTIMTTeanrkqaynYGCLVE 157 starlet sea ane...
AAL89870      83 RYLQEFTALGTAGGMYHFRDQIRagn-praFFVLNGDVCADFPLQELCDFHEKrpasaLVTIMSTeatrqqslhYGCLVF 161 fruit fly
EAL19591     107 SYLREYKALGTAGGLYHFRDSILrppvpqhIFICNIDICCSFPFAEMLELHTShg--gTGTIMGVnvkketatqYGCIVT 184 Cryptococcus ne...
XP_503968     82 KYLREYKAMGTAGGLYHFRDVILkgn-psrFFVIHADVCCSFPLKEIEEFYEEkk--aKYVILGTtvpaavannFGAIVT 158 Yarrowia lipoly...
XP_958781     99 KYLREYQALGTAGGLYHFRDIILkgr-perLFVLNSDVCCSFPLGEMLRLFEEkd--aEAVILGTrvaedaatnFGCIVS 175 Neurospora cras...
CAA18655      83 KYLREYNCLGTGGGLYHFRDQILkgh-tsnVFVMHADVCCSFPLQELLNVHHEkk--aLVTLMATkvskedasnFGCLVE 159 fission yeast
AAF60647      81 KYLEEPNPLGTAGGLVSFKKQILagd-pdaVFVINADVCGDLPIEDMGAKLDSls-gsSMLMLTTeatrqqsinFGSVVT 158 nematode
XP_002119603  87 RYLQEYTSLGTAGGLYHFRDQIGagn-psaFLVFNADVCCNFPLQEILSFHKSkttddGITIVATeatqqesmsYGCVVE 165 Ciona intestinalis
Feature 1                              #                                                         
BAD96671     158 NpQTHEVLHYVEKPSTFISDIINCGIYLFSPEALKPLRdvfqrnqqdgql----------------------edspglwp 215 human
XP_782147    160 NeNTHEVMHYVEKPQTFVSTVINCGLYVFPPEIFQHIGkafqqnqdevl------------------------ngdplfp 215 purple urchin
XP_001636846 158 KeGSHEVVHYVEKPETFVSSLINCGVYIFSLTVFQTLSelmqhtyniar------------------------ddhvgfv 213 starlet sea ane...
AAL89870     162 DrSSGAVSHYVEKPSSYVSTFINCGVYVCSMDIFTVLAqifhsrgqeyscqaf-----------------cngngngngr 224 fruit fly
EAL19591     185 DpETNQMVHYVEKPEGWISNIVNGGVYLFDKSLFDVIKvamdektaraa-------------------------edplvk 239 Cryptococcus ne...
XP_503968    159 DpETQRVIHYVEKPESHISNLINAGVYLFDQTIFDTIAaakkvreekaqd-----------------------psfvgeg 215 Yarrowia lipoly...
XP_958781    176 DaHTRRVLHYVEKPESHISNLINCGVYLFATEAIFPSIrtaikrrtdrpnrlirypsaenlessffaqqaaddddeesek 255 Neurospora cras...
CAA18655     160 EpSTGRVLHYVDKPSSYLSNIISCGIYIFDASIFDEIKkayerrleevek----------------------qlrsldeg 217 fission yeast
AAF60647     159 D-SEGRVIHYVDKPTTFVSTNISCGVYLIKAEVIRQLDlpln-------------------------------------- 199 nematode
XP_002119603 166 DaATGEATHYVEKPETFVSSLINCGVYAFSPKVLQYMEnvfkehqserfds---------------------gddnadqs 224 Ciona intestinalis
Feature 1                                                        
BAD96671     216 gagtIRLEQDVFSALAG--QGQIYVHLTDGIWSQIKSAGSALYASRLY 261 human
XP_782147    216 skdtIRLEQDILAPLAS--TGKLFTFKTNNFWSQIKSAGSAIFANRLY 261 purple urchin
XP_001636846 214 gpevLRMGEDLLTHLAG--TGELFAYKTDRFWTTIKSAGSAIYANRNF 259 starlet sea anemone
AAL89870     225 eqghIKWEQEVLTPLAG--TDKLFAMPVPNWWSQLKTAGSAIYANRHY 270 fruit fly
EAL19591     240 pdeiLRLEQDVIVPLAA--ARKMYVYQTHDFWRQIKTAASAVTATALY 285 Cryptococcus neoformans var. neoformans B-3501A
XP_503968    216 dedhLRLEQDILVQLPA--TDAFYAYETKDFWRQIKTAGSAVPANALY 261 Yarrowia lipolytica CLIB122
XP_958781    256 rsevIRLEQDILSDMAD--SKQFFVYETQDFWRQIKTAGSAIPANALY 301 Neurospora crassa OR74A
CAA18655     218 medyLSLETDVLAPLCSdsSKAIYAYNTPEFWRQIKTAGSAVPANSLY 265 fission yeast
AAF60647     200 -gdgIWLETDVLPQLAS--SGNLYALHTTRWWSQTKTAAAVLYANRHY 244 nematode
XP_002119603 225 fserISLEKEILNPYAG--SGKMFVYKTKEVWGQIKSAASAIHANKLY 270 Ciona intestinalis

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