Conserved Protein Domain Family
M1P_guanylylT_B_like_N

?
cd06425: M1P_guanylylT_B_like_N 
N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins.
GDP-mannose pyrophosphorylase (GTP: alpha-d-mannose-1-phosphate guanyltransferase) catalyzes the formation of GDP-d-mannose from GTP and alpha-d-mannose-1-Phosphate. It contains an N-terminal catalytic domain and a C-terminal Lefthanded-beta-Helix fold domain. GDP-d-mannose is the activated form of mannose for formation of cell wall lipoarabinomannan and various mannose-containing glycolipids and polysaccharides. The function of GDP-mannose pyrophosphorylase is essential for cell wall integrity, morphogenesis and viability. Repression of GDP-mannose pyrophosphorylase in yeast leads to phenotypes, such as cell lysis, defective cell wall, and failure of polarized growth and cell separation.
Statistics
?
PSSM-Id: 133047
View PSSM: cd06425
Aligned: 27 rows
Threshold Bit Score: 339.187
Threshold Setting Gi: 123402013
Created: 13-Dec-2007
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:probable substrate binding site
Evidence:
  • Comment:Predicted GDP-glucose binding site based on similar proteins.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1             ####             #                                                         
O74484         1 MKALILVGGFGTRLRPLTLTLPKPLVEFGNKPMILHQVEALAAAGvtDIVLAVNYRPEIMVEALkkyekeYNVNITFSVE 80  fission yeast
XP_001348376   1 MNALILVGGYGTRLRPLTLTTPKPLINFCNKPIIEHQILHLAKCGikEIILAIAYKPTNITNFVkemekkYNVQIIFSVE 80  Plasmodium falc...
CAD25979       8 VKAVILVGGYGTRLRPLTYTVPKPLVPFANKPILRHQIEALVKVGikEIILALNYYSEFIIREVrdysneLGISIVYSKE 87  Encephalitozoon...
XP_001442401   1 MKALILVGGYGTRLRPLTFKCPKPLVEFANKPILMHQIEALVKVGvqEIILAINYQPDTMKEQInklqdlYKVKIICSQE 80  Paramecium tetr...
XP_765205      1 MKSVILAGGHGTRIRPLTLSVPKPLVEFCNCPVIEHQIKACKNAGfdHIIIAVTEYHNIIEPIKqla-ekYAIRIDFSVE 79  Theileria parva...
XP_001695916   1 MRALILVGGYGTRLRPLTLSCPKPLVEFANKPMIIHQIEALKVAGctEVVLAINYQPEVMLGFIqewqekLGVRIVCSQE 80  Chlamydomonas r...
XP_001610191   1 MKCVILAGGHGTRLRPLTLTVPKPMIPFCNRPIVEYQIKASKEAGvdHIILAISHEQNNMVPMIkelserCNIRIDCSIE 80  Babesia bovis T2Bo
AAT12356       8 LKALILVGGTGTRLQPITFTTPKPLVPFVNKPMLEHQVEALARVGveEIVLAMNYKYKRIIDAVdnfsgrYGTKITYSLE 87  Antonospora loc...
XP_666388     30 MKAIILSGGYGSRLRPLTLTKPKSIVELCNIPIIEFQIAQFASIGitEIIVALNYKANELIPTLkiiedrYAVKVHLSIE 109 Cryptosporidium...
EEA97879       1 MKALVLVGGYGTRLRPLTLSVPKPLINFCNKSIVEYQIHSLKKAGvdHVILAVAYQPSTLMDALsaleqkYSLAITCSRE 80  Toxoplasma gond...
Feature 1                                                                                        
O74484        81 NEPLGTAGPLALARDILakd---------------------------------------------------------hsP 103 fission yeast
XP_001348376  81 DEPLGTGGPLKLAENYLnk----------------------------------------------------------ydD 102 Plasmodium falc...
CAD25979      88 QEPLGTAGPLALAKKYLeg-----------------------------------------------------------hT 108 Encephalitozoon...
XP_001442401  81 TEPLGTAGPIRLAKDHIikdn-------------------------------------------------------pdgL 105 Paramecium tetr...
XP_765205     80 STPLGTAGPLRLAKELIcsdd-------------------------------------------------------dsdD 104 Theileria parva...
XP_001695916  81 KEPMGTAGPLALARETLddg--------------------------------------------------------kgtP 104 Chlamydomonas r...
XP_001610191  81 KESLGTAGPLKLAKNLIcdpa------------------------------------------------------dnckE 106 Babesia bovis T2Bo
AAT12356      88 KEPLGTAGPIALAREYLsg-----------------------------------------------------------sT 108 Antonospora loc...
XP_666388    110 EKPLGTAGPIKLAQDFLke----------------------------------------------------------deP 131 Cryptosporidium...
EEA97879      81 DEPLGTAGPIRLAKDLLlspspalasspdgngggaaavvrerpaprdrescqevsaesaaahgdagndqadarggdaedC 160 Toxoplasma gond...
Feature 1            ###                                                                  #      
O74484       104 FFVLNSDVICEYPF-ADLAAFHKAHG---AEGTIVVTKVEEPSKYGVVVhypnseslIERFVEKPVEFvSNRINGGIYIL 179 fission yeast
XP_001348376 103 FFVFNSDIICTFPL-IEMMNFHKQNK---APLTILVKEVEDPRAFGVVIted---kmITKFEEKPLVPkSSLINAGIYIL 175 Plasmodium falc...
CAD25979     109 FFVLNSDITCRFPL-AEMLSFHYSHG---REGTILSTNVDDPSRYGIIItees-tslVRSFLEKPKDAvSNRVNAGIYIL 183 Encephalitozoon...
XP_001442401 106 FFVLNSDIICEFPL-DKLLQFHKQHN---HEGTIFVNEVDDPSKYGVILade--tgrIKDFIEKPQEFiSNKINSGLYLF 179 Paramecium tetr...
XP_765205    105 FVVFNSDIICNYPL-KELLESHRKNS---AKVTILVTTVENSSEFGVILhde--nglIKSFLEKPKNStSNTINAGVYVL 178 Theileria parva...
XP_001695916 105 FFVLNSDVICDYPL-KDMLDFHKARG---AEATILVTKVDDPTKYGVVVmde--ygqVQRFVEKPKEFvGDKINAGIYVC 178 Chlamydomonas r...
XP_001610191 107 FLVLNSDIICSYPF-AEMISAHRKNN---ADATILVTKTTHPSDFGVIVhde--tyrIHEFVEKPSQFiSNQINAGIYVL 180 Babesia bovis T2Bo
AAT12356     109 FFVLNSDVICEFPL-DDLLDFHRRTA---RLGTILATTVENPEKFGVIKtrkd-svlVEEFVEKPVVYvGNRVNAGIYVF 183 Antonospora loc...
XP_666388    132 FFVCNSDIICNFPLrEMLDLYHKKNSdseCNGVILIKQVSDPSKFGVVLhden-tliVEKFIEKPKDFvGDFINAGIYIL 210 Cryptosporidium...
EEA97879     161 FFVCNSDVICPFPF-KEMLAFHKAKG---AEGTILVTEVENPSIYGVVLhde--egrVSDFIEKPQQFvGRCINAGLYIL 234 Toxoplasma gond...
Feature 1                                                                    
O74484       180 NPSVLDRIEP-RPTSIEKEVFPAMVnd----kQLHSFDLEGYWMDVGQPKDYLTGTCLYL 234 fission yeast
XP_001348376 176 NKQILNFIPQ-RNCSLEKEIFPKLAsd----nMLYFYQLNNFWADIGKPLDFLKGQSLYM 230 Plasmodium falciparum 3D7
CAD25979     184 NPSVLDRIEL-RECSIEREIFPRMAee----hQLQVFDLKGFWMDIGQPADYIKGQGMYL 238 Encephalitozoon cuniculi GB-M1
XP_001442401 180 NVSMIDRIPL-KPTSIEREIFPIMAke----gQLYQYILPGFWKDVGQPKDYLAGTVLIL 234 Paramecium tetraurelia strain d4-2
XP_765205    179 NKEVLDHIPL-KNYSIEKQFFPKYLky----nSSYIYKLDGFWSDIGKPTGYLNGQHLYL 233 Theileria parva strain Muguga
XP_001695916 179 SPSILNRIEL-RPTSIEREVFPHVAad----nRLYAYTLNGYWMDVGQPKDYLKGLHLYL 233 Chlamydomonas reinhardtii
XP_001610191 181 NKNMLDYIPD-GSVSIERYLFPTMVam----gRTYCHPLNGLWADIGKPSDYIRAQQLYL 235 Babesia bovis T2Bo
AAT12356     184 ESDVLQYFKS-RPSSIENEVFPLLAtm----qQLCVYELQGFWMDIGTLEGYLKAQRLYL 238 Antonospora locustae
XP_666388    211 SKRILDLIKPnQQVSIEKDIFPIMAssntlycNKFFTNNENIWADIGNPKDFLLGSKLFM 270 Cryptosporidium hominis TU502
EEA97879     235 NTSVIDRIQL-RPTSIEKEVFPQMAre----kKLFCFKLDGYWADIGQPKDFLKGMTLHL 289 Toxoplasma gondii ME49

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap