Conserved Protein Domain Family
UGGPase

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cd06424: UGGPase 
UGGPase catalyzes the synthesis of UDP-Glucose/UDP-Galactose.
UGGPase: UDP-Galactose/Glucose Pyrophosphorylase catalyzes the reversible production of UDP-Glucose/UDP-Galactose and pyrophosphate (PPi) from Glucose-1-phosphate/Galactose-1-phosphate and UTP. Its dual substrate specificity distinguishes it from the single substrate enzyme UDP-glucose pyrophosphorylase. It may play a key role in the galactose metabolism in raffinose oligosaccharide (RFO) metabolizing plants. RFO raffinose is a major photoassimilate and is a galactosylderivative of sucrose (Suc) containing a galactose (Gal) moiety. Upon arriving at the sink tissue, the Gal moieties of the RFOs are initially removed by alpha-galactosidase and then are phosphorylated to Gal-1-P. Gal-1-P is converted to UDP-Gal. The UDP-Gal is further metabolized to UDP-Glc via an epimerase reaction. The UDP-Glc can be directly utilized in cell wall metabolism or in Suc synthesis. However, for the Suc synthesis UDP-Glc must be further metabolized to Glc-1-P. This can be carried out either by the UGPase in the reverse direction or by the dual substrate PPase itself operating in the reverse direction. According to the latter possibility, the three-step pathway of Gal-1-P to Glc-1-P could be carried out by a single PPase, functioning sequentially in reverse directions separated by the epimerase reaction.
Statistics
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PSSM-Id: 133046
View PSSM: cd06424
Aligned: 6 rows
Threshold Bit Score: 477.719
Threshold Setting Gi: 23504661
Created: 12-Jun-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Substrate
Feature 1:Substrate Binding Site
Evidence:
  • Comment:Putative substrate binding site based on similar proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          # ##                                                       #               
NP_568775 129 AAFVLVAGGLGERLGYNGIKVALPREtttgtcFLQHYIESILALQEasnkidsdgserDIPFIIMTSDDTHSRTLDLLEl 208 thale cress
CAD51539  324 ISFILLAGGLGERLKHKDIKIKLFTNliseetYIEYYCNYIRCFEKyikke--kkkkmNIPFIIMLSDDTYEKTLCFFEe 401 Plasmodium falcipa...
CAJ03882  115 TVFVLVAGGLGERLGYSSIKVSLPVEtatnttYLAYYLRWAQRVGGk-----------EVPFVIMTSDDTHDRTLQLLRe 183 Leishmania major
EAS05470  103 NHTAFVLGGLGERLQYDGIKIGIQFEittgqtFLNYYLDFIRAFNE------------KAELAIMTSDDTYTLTMKLLEe 170 Tetrahymena thermo...
XP_668507 144 VAFVLVAGGLGERLAFEGIKIGIELSmasnitFFQLYTNYIREYQRrlkea--fgediVIPLLIMTSDDTDSMTRKFLEe 221 Cryptosporidium ho...
EDQ55182  131 AVFVLVAGGLGERLGYSGIKIALPSQlttetcYLDLYIQHILAFQEasgk----hegnGIPLVIMTSDDTHLKTQTLLEd 206 Physcomitrella pat...
Feature 1                                                # ##                                 
NP_568775 209 nsyfgmkptQVHLLKQEkvaclddndarla-ldphnkysiqtkPHGHGDVHSLLYSSg------------------LLHK 269 thale cress
CAD51539  402 knyfgleknQVHFLKQNkvfcfknnqahldftyekntfiiskkPHGHGDIHYLINKYn------------------ILDK 463 Plasmodium falcipa...
CAJ03882  184 lql---evpNLHVLKQGqvfcfadsaahl---aldetgkllrkPHGHGDVHSLIYNAtvkrdvvpdsgdgtataqpLVND 257 Leishmania major
EAS05470  171 nnyygfpkdQITIMKQEkvpamidndahf--tqlpnsllietkPHGHGDVHTLLFQHq------------------LPKK 230 Tetrahymena thermo...
XP_668507 222 ndhfglredQVYIVKQLkvpalidsdakia-ldpedkysiltkPHGHGDIHTLLHASg------------------LLKD 282 Cryptosporidium ho...
EDQ55182  207 nkyfgmspnQVHLLKQEkvacladndaria-ldpsdsyaiqtkPHGHGDVHAVLYNSg------------------LLPK 267 Physcomitrella pat...
Feature 1                 ##                                   ##                             
NP_568775 270 WLeAGLKWVLFFQDTNGLLFNaiPASLGVSATKqyHVNSLAVPRKAKEAIGGISKLthvd-grsmVINVEYNQldpLLRA 348 thale cress
CAD51539  464 LIkDGYKYLFFFQDTNALALKvlFVCLGVSIQKqlHMNFLAVSRKPGEEIGALCTLnnne--ksmTVNLEYNIfdsLLSS 541 Plasmodium falcipa...
CAJ03882  258 WLaAGYESIVFIQDTNAGATItiPISLALSAEHslDMNFTCIPRVPKEPIGLLCRTkknsgdpwlVANVEYNVfaeVSRA 337 Leishmania major
EAS05470  231 WIqQGKKWLVVFQDTNPLVFRalPSVLAISKTKnlEVNSITAPRKPGEAVGAICKLtkgn--erlTINVEYNQlgsLLPK 308 Tetrahymena thermo...
XP_668507 283 LFeKGVKFLVFIQDTNALVFNsvLPVLGVTSMNsfVMNSLTIPRIPCEAVGALCKLrypd-gkkiTINTEYNQltpLLKS 361 Cryptosporidium ho...
EDQ55182  268 WQeEGRKWILFFQDTNGLLFKaiPAALGVSSIRdlDVNSLTVPRKAKEAIGGISRLthen-gsemVLNVEYNQldpLLRA 346 Physcomitrella pat...
Feature 1                                                                                     
NP_568775 349 SGfpdgd-vncetGFSPFPGNINQLILElgPYKDELQktGGAIKEFVNPKYKDSTKTAFKSSTRLECMMQDYPKTLPPT- 426 thale cress
CAD51539  542 NGikev---iqkdGFSLYPGNTSAILYEinKYNEILKktNGNIPEYINPKYMDNTRDHFKCPTRIESMMQDIALYFYEHk 618 Plasmodium falcipa...
CAJ03882  338 LNkdggdevsdptGFSPFPGSVNTLVFKlsSYVDRLResHGIVPEFINPKYSDETRRSFKKPARIESLMQDIALLFSEDd 417 Leishmania major
EAS05470  309 EPvd-------ehGYSVFPGNINSIVFSlqEYDSVLEktKGLIMEFINPKYADATKTKFKSSSRLECMYQDYPKLLEND- 380 Tetrahymena thermo...
XP_668507 362 CGlgsdf-adektGYSPFPGNSNVLFISmdYYMKTLEktGGVVPEFVNPKYLDSTKTAFKSPTRLECMMQDIPLLFEAD- 439 Cryptosporidium ho...
EDQ55182  347 SGhpdgdvndpatGYSPFPGNINQLVMKigPYMKELSrtKGAIVEFVNPKYKDATKTAFKSSTRLECMMQDYPRTLPPS- 425 Physcomitrella pat...
Feature 1                                                                                     
NP_568775 427 ----------------------------------------------------------------------ARVGFTVMDI 436 thale cress
CAD51539  619 rnkttqastvmgentqmvmrdntqtvmgdntqtvmrdntsivipnnstinnsicndkkgnnmddinlydiTNVGVTELDR 698 Plasmodium falcipa...
CAJ03882  418 ----------------------------------------------------------------------YRVGGTVFER 427 Leishmania major
EAS05470  381 ----------------------------------------------------------------------NRVGMTQVNR 390 Tetrahymena thermo...
XP_668507 440 ----------------------------------------------------------------------YKVGCVQMQR 449 Cryptosporidium ho...
EDQ55182  426 ----------------------------------------------------------------------AKVGFSVLDT 435 Physcomitrella pat...
Feature 1                
NP_568775 437 WlaYAPVKNNP 447 thale cress
CAD51539  699 ClcFSPVKNNS 709 Plasmodium falciparum 3D7
CAJ03882  428 Fs-YQPVKNSL 437 Leishmania major
EAS05470  391 AfcFSTVKNDI 401 Tetrahymena thermophila SB210
XP_668507 450 WatFSACKNSL 460 Cryptosporidium hominis TU502
EDQ55182  436 WvaYAPVKNNP 446 Physcomitrella patens subsp. patens

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