Conserved Protein Domain Family
CESA_like

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cd06423: CESA_like 
CESA_like is the cellulose synthase superfamily.
The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.
Statistics
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PSSM-Id: 133045
View PSSM: cd06423
Aligned: 115 rows
Threshold Bit Score: 87.6678
Threshold Setting Gi: 46107638
Created: 27-Jun-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
DXD motif
Feature 1:DXD motif
Evidence:
  • Comment:DXD motif in the catalytic site could be in binding the metal ion that is used to corordinate the phosphates of the NDP-sugar in the active site.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
YP_062911     45 FFVPCRDEaAVIERTVAAARrdf---pavHVWVVDDHSDDdtgriveaiarrds--rvhlvtrrrpeartGKGDALNAAy 119 Leifsonia xyli ...
ZP_01873031   29 VLVPAHNEeAVIEGCLECMNkldykkdqlEVIILNDRSSDgtkdlidnflrknpk-shirahhrpmsaepGKAAAMKEIi 107 Lentisphaera ar...
ZP_03285816   28 VLVPMHNEeKVAENVLNALLntdypkdriEIIPIDDNSTDrtreiledysskyp--hlikplyrgsylprGKPSALNDAl 105 Dictyoglomus tu...
YP_112018    149 VFVAAHNEeAVVADCLTALLattyprerlTIVPVNDRSTDntralidevqarap---elikpfhresgkpGKAAALKDAl 225 Burkholderia ps...
YP_001320900  47 ILIPAHNEaKVIKKTLEAMVkldy-pgtiQIYLLNDQSQDdtgdiaeafantyt---nihhirvpdgqpkGKSRVLNYGl 122 Alkaliphilus me...
NP_834900     72 IFIPAHNEgVVIKDTLEAMAkiey-pgklTIYLLNDNSQDetpeigddfdkaya---hirhirvppgepkGKSRVLNYGl 147 Bacillus cereus...
AAO35436      56 IIVPAHNEeKVIEKTVKSLLlldypknkmEIIVVNDNSQDntatllenlkreydmdnlkiintdnitggkGKFNALNIGf 135 Clostridium tet...
CAB12237      53 VLIPAHNEeVVIRQTLKAMVnlyypkdrlEIIVVNDNSSDrtgdivnefsekyd--fikmvitkppnagkGKSSALNSGf 130 Bacillus subtil...
YP_045879     54 VLIPAYNEgVVIEDTLHAIAgqdypdhayEVLLINDGSKDntleiaermakiyp--cikivnvpkgmggkGKSRTLNNGl 131 Acinetobacter s...
CAB50572      79 VLIPAHNEeRVIYKTVRSVLgqdy--rnmKVILINDNSTDrtrdimeeinrkyp--rkvviidvppergrSKPRALNYAl 154 Pyrococcus abys...
Feature 1                             ###                                                        
YP_062911    120 dalnaflpadadreriIVMVLDADGelsaralammasaevfldpgvGGAQVVVWMKNrherrpkpghgwlgnlfgrfLVK 199 Leifsonia xyli ...
ZP_01873031  108 atl----------kseIIVIFDADYlpqadlikrl--inpfkdpevGATMGRVVTYNana---------------niMTK 160 Lentisphaera ar...
ZP_03285816  106 kva----------egeIIIVFDADYippkgiirdl--avsfldpevGVVMGRVVPLNisk---------------nlLTR 158 Dictyoglomus tu...
YP_112018    226 rei----------rgdIMVVFDADYlprpgllkel--vapffdpevGAVMGRVVPQNadr---------------nlLAR 278 Burkholderia ps...
YP_001320900 123 sis----------kskYFVVYDADNqpeplslkll--veaaentqnAAGAVGYVRTVnad--------------kniLTR 176 Alkaliphilus me...
NP_834900    148 sis----------dgeYFCVYDADNqpephalrml-vehaettedaVGAVGHVRTVNekr---------------nwLTR 201 Bacillus cereus...
AAO35436     136 nhs----------vgeLIAIYDADNtpnklalkyl-vqtikkdenlGAVIGKFRTRNker---------------nlLTK 189 Clostridium tet...
CAB12237     131 aes----------ngdVICVYDADNtpekmavyyl-vlglmndekaGAVVGKFRVINaak---------------tlLTR 184 Bacillus subtil...
YP_045879    132 pha----------kgeLIVVYDADStpepncvrll-aqtlladaklVAVNGKVRTRNwqd---------------siLTH 185 Acinetobacter s...
CAB50572     155 eiiek-----ymthpnYVFILDADYlippnalktlvsimesapqyvIGIQGNVRPRNfrk---------------nfVTK 214 Pyrococcus abys...
Feature 1                                                                
YP_062911    200 LQDIEFRtiiaamqslr-artgtvglgGNGQFARLSVLdlirashdrpwhgALLED 254 Leifsonia xyli subsp. xyli str. CTCB07
ZP_01873031  161 LIDLERRsgyaidqnvrnhfdllpqfgGTTGGIRLSALedvgg----wdtrTLTED 212 Lentisphaera araneosa HTCC2155
ZP_03285816  159 LFDLERIggyqvdqqarynlklipqfgGTVGGFRKELIlklgg----fnpkILAED 210 Dictyoglomus turgidum DSM 6724
YP_112018    279 LLDLERAggyqvnqqarnnlglvpqygGTVGGVRKSALdavgg----wrddTLAED 330 Burkholderia pseudomallei K96243
YP_001320900 177 MISLEFQvfqllmqsgrwflfktgsltGTNMLVKRSTLdlvge----ydvyALAED 228 Alkaliphilus metalliredigens QYMF
NP_834900    202 MISLEFQifqllmqsgrwllfqtgsltGTNMLLRRSALeelgg----ydpyAIAED 253 Bacillus cereus ATCC 14579
AAO35436     190 FINIETLsfqwmaqagrwqlfnlctipGTNFIIRRDIIkeigg----wdikAIAED 241 Clostridium tetani E88
CAB12237     185 FINIETIcfqwmaqggrwkwfkiatipGTNFAIRRSIIeklgg----wddkALAED 236 Bacillus subtilis subsp. subtilis str. 168
YP_045879    186 FIAIEFIffqwifqggrwqrfelstlmGTNYVIWREALetlgg----fdekSLVDD 237 Acinetobacter sp. ADP1
CAB50572     215 FITLERLvgfnvaiegdmklnengkygGTVALLRFPLLirlgk----fredSVTED 266 Pyrococcus abyssi GE5

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