2Z87,2Z86


Conserved Protein Domain Family
GT2_Chondriotin_Pol_N

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cd06420: GT2_Chondriotin_Pol_N 
Click on image for an interactive view with Cn3D
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase.
Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.
Statistics
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PSSM-Id: 133042
View PSSM: cd06420
Aligned: 28 rows
Threshold Bit Score: 218.601
Threshold Setting Gi: 119358109
Created: 10-Nov-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Substratemetal binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:Substrate binding site
Evidence:
  • Structure:2z87_a Chondroitin Polymerase From Escherichia Coli Strain K4 (K4cp) Complexed With Udp- Galnac. defined by 3.5A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           ### #                          #                                # #   #      
2Z87_A        96 IVIPTYNRAKILAITLACLCnqktiyDYEVIVADDGSKENIEEIVREFes----llNIKYVRQKDYGYQLCAVRNLGLRA 171 Escherichia coli
2Z86_A        97 IVIPTYNRAKILAITLACLCnqktiyDYEVIVADDGSKENIEEIVREFes----llNIKYVRQKDYGYQLCAVRNLGLRA 172 Escherichia coli
YP_001155390   4 ILLATYNWPQALKLCLESLAtqg-dlDFEIIIADDGSGKETKELIDSMkta--fpvPITHLWQEDLGFRKTIILNQAIAA 80  Polynucleobacte...
YP_982281      5 FIVLTYNRTDALLAVLRSLAeqc-npEHEVLIADDGSRQDQVEMLLERcpa--fscPVRHVWHPDVGFTAAGARNLAAHV 81  Polaromonas nap...
ZP_01852565    6 VIITTYNWPAALEAVLTGYLsqs-rpPDELIIADDGSTDETREVLDHFrsq--apfPVKHVWHADEGFRAGAIRNRAIQD 82  Planctomyces ma...
YP_001231958   5 VIVPTFNRPQALRLCLMSLAgqs-rlPDEVLIADDGSGEETRRTIEAFghspdchfTLKHIWQENVGFRKPKIINETVRN 83  Geobacter urani...
YP_529208      9 VIFSTYNSPKWLEKVLWGFDcqt-ddNFEIVVADDGSKEDTQRVIEKFaaq--ssvPVKHVWQEDDGFQKCKILNKAIVE 85  Saccharophagus ...
ZP_01733047    5 VIITTYNSEVWLQKVLEGYCnqt-etNFEVVIADDGSTENTKLIIDSFshk--fqfPIQHIWQEDNGFQKCKILNKAILK 81  Flavobacteria b...
ZP_00950177    8 VIISTYNKPKDLSLVLHGYLeqt-ekDFEIIIADDGSTEETQQMLAKFsek--hniKIYHVWHKDQGFQKTKILNKAILQ 84  Croceibacter at...
NP_933092      7 LIIAFYNNTQALGLIFKALSaqs-cmDFEVVIADDGSKEDAVTWLEEQknq--vpfALKSVWHEDKGFRKNRILNHAVLA 83  Vibrio vulnific...
Feature 1                 # #                                                                    
2Z87_A       172 AKYNYVAILDCDMapnpLWVQSYmellavddnVALIGPRKYIDTSKHTyldflsqkslineipeiitnnqvagkv----- 246 Escherichia coli
2Z86_A       173 AKYNYVAILDCDMapnpLWVQSYmellavddnVALIGPRKYIDTSKHTyldflsqkslineipeiitnnqvagkv----- 247 Escherichia coli
YP_001155390  81 AHGDYLVFLDGDClvqpDFVARHrala--qkgYLVTGSRVLLSESLTQqllqwpswnfqslmakllghrvngg------- 151 Polynucleobacte...
YP_982281     82 AKGDYLVFLDGDCipnkSFVAWHtlla--esgFFVNGSRVLLNKTLTAevlsgevnlphcsaffwfrarfqg-------- 151 Polaromonas nap...
ZP_01852565   83 SEADYLVFTDGDCipapWFIAAHerla--etgWFLSGNRVLLSEKFSRevleqkipvsnwtwsdwlqarrrkq------- 153 Planctomyces ma...
YP_001231958  84 ATGDYLVFIDGDCmahpDFVRSHllsa--epkVMLGGKRVEVGQLLSEyalreqqlvsrlsirllldsfahns------- 154 Geobacter urani...
YP_529208     86 AEGEYLVFTDGDCvprnDFIAVHrqqa--eagRFLSGGYLKLNMPVSQkitredikygrcfvpawlrdngmp-------- 155 Saccharophagus ...
ZP_01733047   82 TNSEYLLFTDGDCiprkDFVAQHlkyk--eegYFLSGGYFKLPMETSNiislenikhqhcfsiswlikngvsk------- 152 Flavobacteria b...
ZP_00950177   85 SNSNYLLFTDGDClprkDLVKKHielr--rdkHFLSGSYYKLNEQVSEtitipiikeqscfnakwlkskgqdv------- 155 Croceibacter at...
NP_933092     84 AESEYLIFIDGDCipekHFIEDHinna--qrgSVLSGRRVELPELFTPlmqacenpetffsqhkwqifrqylftspdaet 161 Vibrio vulnific...
Feature 1                                           #                         ##                 
2Z87_A       247 ----eqnksvdwriehfkntdnlrlcntpfRFFSGGNVAFAKkwlf-ragwFDEEFTHWGGEDNEFGYRLYreg---cyf 318 Escherichia coli
2Z86_A       248 ----eqnksvdwriehfkntdnlrlcntpfRFFSGGNVAFAKkwlf-ragwFDEEFTHWGGEDNEFGYRLYreg---cyf 319 Escherichia coli
YP_001155390 152 ------inkywplkiklgdgvwrhykkfvwRRIKGCNMACWKadak-aihgFDETMTGWGHEDADFVFRLQrnh----ii 220 Polynucleobacte...
YP_982281    152 ------dsnkllhlirwplslfrvqqdfqwRGIRSCNFGVWRhdfv-svngFDETFQGWGHEDADLVLRLHhlg----lk 220 Polaromonas nap...
ZP_01852565  154 ------inrllplfqiplgtryrrrlarqwEGAKTCNLSAWKqdll-avngFDEDYTGWGMEDSDLVLRLIrng---iyh 223 Planctomyces ma...
YP_001231958 155 -----rkveeavriknpllrkllrkdqisdDGIWGCNFSVRKdqfy-aingCDEDFRDGSVEDNDLGIRVLnsg---gkl 225 Geobacter urani...
YP_529208    156 ------stkgfmklnagrlagllnkitptkPTWNGHNASCFKsdal--rinGYDERLRYGGLDREFGERLEnag---iag 224 Saccharophagus ...
ZP_01733047  153 ------sfklskltkfkpfavfmnwltptkRTFNGHNTSCFKndli--avnGFNEEMQYGGLDREVGERLFnlg---ils 221 Flavobacteria b...
ZP_00950177  156 ------tfkinkltsfgfkewflntftttkATWDGCNVSGWKkdil--avnGFDERMQYGGEDRELGERLVnygvqpiqa 227 Croceibacter at...
NP_933092    162 kgrcnrgrhvekgirlpyawqqkliggfkpAGILGCNFSLYKsdllkvngfDMRYEAPAVGEDSDLDYRLGlig---itt 238 Vibrio vulnific...
Feature 1                   #  
2Z87_A       319 RSVe--gAMAYHQE 330 Escherichia coli
2Z86_A       320 RSVe--gAMAYHQE 331 Escherichia coli
YP_001155390 221 RKSgswaTEVFHLF 234 Polynucleobacter sp. QLW-P1DMWA-1
YP_982281    221 RKNgfmaTEVFHLW 234 Polaromonas naphthalenivorans CJ2
ZP_01852565  224 KDArf-aAAVFHIW 236 Planctomyces maris DSM 8797
YP_001231958 226 KSVrf-lAIVFHLW 238 Geobacter uraniireducens Rf4
YP_529208    225 KQIry-sAVVVHLD 237 Saccharophagus degradans 2-40
ZP_01733047  222 KQIry-sAICLHLD 234 Flavobacteria bacterium BAL38
ZP_00950177  228 RYSl--vCVHLHHD 239 Croceibacter atlanticus HTCC2559
NP_933092    239 RVLkg-lAIQLHIY 251 Vibrio vulnificus YJ016

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