1SFS


Conserved Protein Domain Family
GH25_BacA-like

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cd06418: GH25_BacA-like 
Click on image for an interactive view with Cn3D
BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of Bacillus subtilis. BacA has a C-terminal catalytic glycosyl hydrolase family 25 (GH25) domain and an N-terminal peptidoglycan-binding domain comprised of three alpha helices which is similar to a domain found in matrixins.
Statistics
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PSSM-Id: 119380
View PSSM: cd06418
Aligned: 28 rows
Threshold Bit Score: 149.793
Threshold Setting Gi: 118473869
Created: 28-Jul-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      #                            #                                 # 
1SFS_A       18 LYFQSNAMARGIWGVDSAqvvtdq---lfqcvrTELGYPKFWGRYLSEVpnv-----seGLTRDEIVRIRNYGVKVLPIY 89  Geobacillus stea...
YP_891020    25 VLAGLGAGVSAAPASAAApqlidfaaaqipaehIKAAGYAGVINYVSTSrpgss-fgakPITRPYAESLTRAGLVIVSNY 103 Mycobacterium sm...
CAD31268     29 TARADDKTPRTYSAVDCYsypgdd----aikqlREQLKFDIVGFYLNHVrgt----pdlTWTYDRRSDLAMSGWGFFPTY 100 Mesorhizobium loti
ZP_02867926 270 LMSSNGDTSRPAIGCDTAtkltp-----tqiqtLVDNGYRYVGRYVSNTpggt---ldkALTKTEVNNILNAGLKLFLIF 341 Clostridium spir...
BAG12403    282 LLSSAGNTDRAASACDMAtqltk-----qqaqlIKDNGYSIVGRYLTGSvgvgankkdkNLTLEEIQAITSVGLSIFPIY 356 Enterococcus fae...
ZP_01170399  35 SGGNETDPESVVWGVDSAslttee---lfscvrDNFGNPQIWGRYLGTKegv-----sqGLTKEEAAFLQSNNAGILLIN 106 Bacillus sp. NRR...
NP_243081    95 GQRDGDDLPEIVWGVDSVnvtdss---fldcvtTNFGSPTIWGRYLGDKedv-----syGLTPEEIELLHDHDISILIIY 166 Bacillus halodur...
YP_591946    38 GLAVAQESQPYHLGFDRNvypg-------ddllPALHKTFEWTGYWLNNppg----anrNTWAGKREMMKAAGFGFAVLY 106 Acidobacteria ba...
NP_824716     3 ATTWPAQRTFTGRAFDTCaapsl-----samkaWHTGFYGAAAVYVGGKnrgc---gqpNLTASWVKSVSTLGWKLIPLY 74  Streptomyces ave...
YP_925514    68 AANPVTPGDFTGFGFDQChtpeqr----kmnrwLQSSPFLAVGIYISGDsrac--reqpELTPTWVRTQLAKGWRLLPIT 141 Nocardioides sp....
Feature 1       #                                                            # #                
1SFS_A       90 Naf-------------------------reAVGYANGQVAARNAVFHARRLGipknkLLFANIEDFfa-------vdAAW 137 Geobacillus stea...
YP_891020   104 Qygkpgg-----------------tapsdfRRGAAGGVADAKTAWQLHTAAGgarnaPIYFSVDEDidrqt-wnnlaLPW 165 Mycobacterium sm...
CAD31268    101 Iggdl----------------------slmVSKPELGIKHGLEAAQFMTDVGfgqgsVVYLDIEKPage-----lqlSPY 153 Mesorhizobium loti
ZP_02867926 342 Qesgn----------------------sveRFNFSTGIQNATSAIAAVKNLGyssfvPIYFAVDFDatdtq-iksniLPY 398 Clostridium spir...
BAG12403    357 Qdggw----------------------eesYFNEGNGLRDGSLAHNAAFKLGfpygaTIYFAVDVDildgn-ipgtvLPY 413 Enterococcus fae...
ZP_01170399 107 Nqf-------------------------tdATGMENGTEIGNLGIQLASELGvpegtAIFADIEPDyp-------vdSDF 154 Bacillus sp. NRR...
NP_243081   167 Nqf-------------------------idATGYETGVNEAEGALAFAEELGipegvAIFANVEPEyp-------vdGAF 214 Bacillus halodur...
YP_591946   107 Ngrlyn--------------------elkgKNPAQIGQKDGRDAAARANAEGfragaIIFIDQEQGgrml----eeqQAY 162 Acidobacteria ba...
NP_824716    75 Vgaqppcqtg------------sspekitaSTAASLGATDAADAVAKASALGmkagsPIYLDMESYdvtdkacndavLTY 142 Streptomyces ave...
YP_925514   142 LgpqascqprfprygddetiiprpganggySKAKKQGNAEAVKSVGVAADLGiapgsTLWYDLEGFdlrntrcresaLAF 221 Nocardioides sp....
Feature 1                          #                             #                              
1SFS_A      138 IAAWVETLYPTg--yRPGLYADPTKGdfaaayceavs-rnnqvavqavIWSAAprpgttkeqkap-----ryqpaappcs 209 Geobacillus stea...
YP_891020   166 FRGINSVIGVQ----RTGVYGGVNVCq---------------------WAIEDgvigr--------------------sg 200 Mycobacterium sm...
CAD31268    154 LNNWIKAVKSRk--fYPGFYGSYSMAdwlknlssalwsvelpapvaavSYDSDdnptglitsrciatqylqkqklaiikg 231 Mesorhizobium loti
ZP_02867926 399 FKAIVDTIKKDandfQIGVYGTRNVCatvrdt----------ypevgrLFISDssygysg----------------nlgy 452 Clostridium spir...
BAG12403    414 IKKVKESLDANgm-yKTGIYGTRNVCqqaida-----------gfvehCFVSDmstgfsg----------------nlgf 465 Enterococcus fae...
ZP_01170399 155 IRGYYGAMSESp--yEAGIYGVFSSNstlyaaynnaaadsaglkenviIWTAYpqagisteseap------ayspeapeg 226 Bacillus sp. NRR...
NP_243081   215 LAGWYDTLTEAn--yPPALYGLFDDDsnvtialeeareenetifeeliLWSNQpqvgitseenap-----dsfdvnapdg 287 Bacillus halodur...
YP_591946   163 LHAWFDAVIAAg--fKAGVYCSGMAAegvvtakdih---dhaqgrkiaIWAYNdacspsrgcyfpk----nppspaksgi 233 Acidobacteria ba...
NP_824716   143 VRAFDKALHAKt--yRTGYYGFRSSSakavadat------drtdlpgnLWYALwdkq----------------------n 192 Streptomyces ave...
YP_925514   222 LSGWTWQIHRLg--yASGVYSGASSGikmlddarvn--rpgqvvlpdqIWLARwdgkant----------------sssy 281 Nocardioides sp....
Feature 1             #                                    #    
1SFS_A      210 anVWVWQYGRdae--------------------------vcpVDTNLA 231 Geobacillus stearothermophilus
YP_891020   201 tpGKAWAWQTrswskgkih--------------paavlyqhtIDTASN 234 Mycobacterium smegmatis str. MC2 155
CAD31268    232 tpGGDGTYDLsrsl------------------------aadpSDTACI 255 Mesorhizobium loti
ZP_02867926 453 tmPKTWSFDQfatditig-----------------ngegkvtIDKVAV 483 Clostridium spiroforme DSM 1552
BAG12403    466 pmPKEWAFDQfyehs----------------------elgfpIDKVAV 491 Enterococcus faecalis
ZP_01170399 227 saVLGWQYGLdae--------------------------acnIDTNLF 248 Bacillus sp. NRRL B-14911
NP_243081   288 srPLGWQYGLead--------------------------tcnIDTNLF 309 Bacillus halodurans C-125
YP_591946   234 pyAEIWQYAQsprrgeakacpknynadgncyppelpvetkthVDLNTA 281 Acidobacteria bacterium Ellin345
NP_824716   193 ttTADWPFGAgqwtnhsrahqym------vnskesrggytitVDRDAW 234 Streptomyces avermitilis MA-4680
YP_925514   282 lrEDGWRPHArikqyqgghd-------------etwggvtinIDRNFL 316 Nocardioides sp. JS614

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