Conserved Protein Domain Family
GH25_LysA-like

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cd06417: GH25_LysA-like 
LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase family 25 (GH25) domain of LysA has sequence similarity with other murein hydrolase catalytic domains while the C-terminal domain has sequence similarity with putative bacterial cell wall-binding SH3b domains. This domain family also includes LysL of Lactococcus lactis.
Statistics
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PSSM-Id: 119379
View PSSM: cd06417
Aligned: 8 rows
Threshold Bit Score: 281.637
Threshold Setting Gi: 116490316
Created: 13-Jun-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #                      #                            # #                     
AAS57574      2 LKMVDVFSgsprs--fatlpETDITMVKATQGIgYVNPACNIDYANAKAAGKLLGLYHYCag----gnPIAEADYFINNI 75  Lactobacillus fe...
CAA10710      1 MNGIDISSyqael--nagivPSDFVIIKATEGTnYINPTWEEQAGQVIQTNKLLGFYHFAsv----gnPIAEADFFISVV 74  Lactococcus lactis
NP_815749     1 MNGIDISSwqsninvgkegvPADFVIVKATGGTgYINPDCDRAFQQAISSGKKVAVYHFAnevglegtAEQEAEFFLKNI 80  Enterococcus fae...
ZP_00120808  34 MVGIDVSGwqasn--vtctaSYDFAVVKVSQGVgFENSSWRTQAKCVTDRGKSLGLYHYAgg----nnAASEADYFVGRA 107 Bifidobacterium ...
ZP_02028679  51 MNVIDVSGwqsad--vtrvvDADAAVVKVTEGGgYVNPSWRSQIDWARQTGKACGGYHYAdg----gnVTAEVNHYLNQF 124 Bifidobacterium ...
ZP_02207814  12 MDGIDISAwqdti--ditkvPCDFVIVKATEGTdYKNRFFAKHCDQAMKAAKLLGAFHYAng----gdPHSEAEYFLAYS 85  Coprococcus euta...
ZP_02918384  33 MNGIDVSGwqapd--itsvvDADFAIVKVNQGT-WLNSSWRTQAANAVNTGKELGLYDYAsg----mnATAEADAFVDRI 105 Bifidobacterium ...
YP_809860   464 MNGYDESSyqsgi--sngsiSGSFVIVKATQGTdYVNPAEASEVASTVAAGKKLGLYSYAet----gnAISEAEYFVSNI 537 Oenococcus oeni ...
Feature 1                  # #                                #                     #           
AAS57574     76 KNYVGEAVLAVDWEgyqns--swgnYNYVRQFVNRVHELTGVWCMVYVSQSEirqvan---cindcpLWVAYYkysqpln 150 Lactobacillus fe...
CAA10710     75 KNYIGKAVLVLDFEagai---nawgNVGARQFLNRVKEKTGINPMIYMSSDVtrqfnws-tisstnpLWVAQYasmnptg 150 Lactococcus lactis
NP_815749    81 KGYIGKAVLVLDWEstn-----kgdVAWAKRWLDYVQGKTGVKPMFYTYTNVlqsynfssiakadygLWLADYgannpqg 155 Enterococcus fae...
ZP_00120808 108 RDYIGRAVLVLDWEsyqna--qwgnSDWVRRFVQRVHTLTGVWPMVYVQASAlgqipgd--vrancgLWVAQYasnaptg 183 Bifidobacterium ...
ZP_02028679 125 NGYVGQCVLALDWEsygnh--awgnGDWVRQWVNQVYSRTKVWPMVYVQDSAvyqipsd--vrshcmLWKAQYasmnatg 200 Bifidobacterium ...
ZP_02207814  86 KKYVGKAILVLDWEgqnnpqfgrsdRAWCKEWCDYVYRKTRVKPLIYIQKSAmdnvk-----nlgyrLWVAQYpdyeqtg 160 Coprococcus euta...
ZP_02918384 106 GGYVGKAMLVLDWEsyqns--afgnSSWIREWVNRVHERTGVWPVVYCSKSVvsqipsd--vrahcmLWAAQYannnatg 181 Bifidobacterium ...
YP_809860   538 KSYLKDNPILILDWegsa---ltqgPTWAKQWLDEVHNLTGIRPLIYMSKSVtseynws-svapnygLWVAEYattastg 613 Oenococcus oeni ...
Feature 1                            #              #           
AAS57574    151 wdyq--gagfniapwevFTIHQFTGs--------dMDRNMVNTTKEGW 188 Lactobacillus fermentum
CAA10710    151 yqsepwtdgkgygawssAAIHQYSSagslsnwsgnLDINLAYINANQW 198 Lactococcus lactis
NP_815749   156 ysqp---tpppvpywnfISMYQYTSngqlpgwngrLDLNVFFGDRSMW 200 Enterococcus faecalis V583
ZP_00120808 184 yqs-----rpwnyaiygEAMRQYTSngwvngyngpLDLNYFRGDASQW 226 Bifidobacterium longum DJO10A
ZP_02028679 201 wqs-----tpwnagskgEGMVQYAStgyln-gvgpLDLNLFFGERDAW 242 Bifidobacterium adolescentis L2-32
ZP_02207814 161 yqe-----hpwnegqydCSIRQYTSvgrlpgyegnLDLNKSYIDKATW 203 Coprococcus eutactus ATCC 27759
ZP_02918384 182 yqs-----spwnagssgEGMLQYSSsgyln-grgpLDLNKFFGDRTAW 223 Bifidobacterium dentium ATCC 27678
YP_809860   614 yqsnpwtnnddygawstPTIFQYTDngslsgyggaLDLDLFYGDFEDW 661 Oenococcus oeni PSU-1

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