Conserved Protein Domain Family
GH25_LytC-like

?
cd06414: GH25_LytC-like 
The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a C-terminal glycosyl hydrolase family 25 (GH25) domain and an N-terminal choline-binding module (CBM) consisting of eleven homologous repeats that specifically recognizes the choline residues of pneumococcal lipoteichoic and teichoic acids. This domain arrangement is the reverse of the major pneumococcal autolysin, LytA, and the CPL-1-like lytic enzymes of the pneumococcal bacteriophages, in which the CBM (consisting of six repeats) is at the C-terminus. This model represents the C-terminal catalytic domain of the LytC-like enzymes.
Statistics
?
PSSM-Id: 119376
View PSSM: cd06414
Aligned: 44 rows
Threshold Bit Score: 196.635
Threshold Setting Gi: 15903474
Created: 31-May-2007
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1            #                             #                                  # #        
NP_359024    302 KKIIDISEHNGRIn----DWKKVIDenKVDGVIVRLGYSgk-------eDKELAHNIKELNRLGIPYGVYLYTYAenetd 370 Streptococcus p...
ZP_02092212  277 TFGIDVSKYQSGL-----DWNKIKKs-GVSFVIIRIGYRgygaagnlvkDPMFEEHFTNARNAGLKVGAYFFTQAvneae 350 Faecalibacteriu...
YP_815282      2 IPGIDISEWQGHV-----DFNAVKAs-GVKFVLIRAGYGrsa----sqvDHYFAEHYAQAKAAGLQVGAYWYSYAvspad 71  Lactobacillus g...
ZP_02862922   80 VNGIDVSVWNNNI-----NWTKVKNa-GIKYVFIRVAARgygksgtifdDSMFVKNINGAKAAGIKVGVYFFSQAitkae 153 Anaerofustis st...
ZP_02085212  100 FRGIDVSRWQGDI-----NWSQVAAd-DVSFVMLGTRSKga-------vDPYFHRNIQQASAAGVKVGVYIYSLAmtpem 166 Clostridium bol...
ZP_02084286  105 EKGITVTKYQNRAnengiDWSRVASd-GVSFAMIRVGYYkd-------kDPYFDRNVTEAFANGIHTGVFFYTQAldvqt 176 Clostridium bol...
YP_001691680 574 QQGADLSKFNRYV-----DMRLAKKn-GMDFVILKAGSGys------geDPKFQQNYNNAKAAGLNVGAYWYSYAvnvee 641 Finegoldia magn...
ZP_02074340  162 IDGIDISRWQGKI-----DWKKVKAd-GVKFAIIRVALRttesg-vleaDALYKENLQGAIDAGLDVGVYIYSQAistae 234 Clostridium sp....
ZP_02444063    5 IKGIDISSHQGDI-----DFERVKAd-GVRFVIIKAGQGlr------emGTFRQKYLPAVLAAGLDWGAYWWSDAvtvae 72  Anaerotruncus c...
ZP_02207438   86 QKGIDVSEWNGSI-----NWKKVKAs-GITFAFIRVGGRyygsg-kfyvDANYRENLKGAIAAGLDVGVYFYSQAinsse 158 Coprococcus eut...
Feature 1                                 # #                                            #       
NP_359024    371 AENDAKQTIELIkkynmnlsYPIYYDVEnweyvnksk-----rapsdtdtwVKIINKYMDTMKQAGyqNVYVYSYRSLlq 445 Streptococcus p...
ZP_02092212  351 AQEEAEGCNWALngr--mldYPIFYDTEastapggtgr----adglgaedrTKCAIAFCERVKELGy-TPGVYASTTWyr 423 Faecalibacteriu...
YP_815282     72 AANEARACLTVLgnr--hfdYPIYFDLEekwqfa-----------ngrnfcDSLVKSFCSVLEQNGc-YAGLYISRSPlq 137 Lactobacillus g...
ZP_02862922  154 ARQEANYTLNKIkgy--kmdLPVVMDYEysggssgrlt----qaklsktaaTNICMEFLNTIKAAGy-TPMLYANYSMln 226 Anaerofustis st...
ZP_02085212  167 AVEEANFVLNLIhdy--pvsYPVAFDMEdstqgt-----------lskdelAAIANAFCGRISEAGy-YPVIYANDNWla 232 Clostridium bol...
ZP_02084286  177 AIDEANFVLKVIkdf--pisYPIAYDVEsqhlldn---------gltrqqiTDNVNAFCKTISDAGy-HPVVYGNNEWlt 244 Clostridium bol...
YP_001691680 642 AKEEAVRYMKILgkk--qfeYPVYLDFEdpsqrk-----------ipketkTDMAIAFMSILEKNGf-YTGLYSSGSWin 707 Finegoldia magn...
ZP_02074340  235 AKAEADFTMNLLkgy--dinLPIVMDFEyytgntgrla----rahlsvaqaTTICNAFCKEVESKNy-TAMVYANKSLlt 307 Clostridium sp....
ZP_02444063   73 AQKEAAAFVRALdgl--rptYPVYMDQEyespcgnaw-----gvgkgkqlrTDMAKAFLKVLEDAGy-YAGLYASTNWlq 144 Anaerotruncus c...
ZP_02207438  159 AKAEAAYTMNLIsgy--ninLPIVMDYEyaweegvgitgrlynanlsksaaTTVINSFCSAVEIRGy-VGMLYASKSVit 235 Coprococcus eut...
Feature 1                      #                         #                  #     
NP_359024    446 trlk-hpdilkHVNWVAAYtnalewe----npyysgEKGWQYTSSEYMKGIqg----rVDVSVWY 501 Streptococcus pneumoniae R6
ZP_02092212  424 krvdyntlrsrYTIWNAHYgvss---------spigCDLWQGTEKARINGYsg----eLDANISY 475 Faecalibacterium prausnitzii M...
YP_815282    138 nyis-ptvaqrYAIWIAEYgprcn--------yggnYGIWQHYSTGSVPGVsg----nCDLDYAY 189 Lactobacillus gasseri ATCC 33323
ZP_02862922  227 yslnketidakYAVWLAHYststs--------yngdYTFWQYSSDGKVSGIsg----rVDMNFWY 279 Anaerofustis stercorihominis D...
ZP_02085212  233 nkld--mskmnYPVWVARYsakp---------ayqnPVMWQATSTGAVNGIsg----nVDIDFQF 282 Clostridium bolteae ATCC BAA-613
ZP_02084286  245 rnmd--tgqipYDIWYARYgtvn---------sypnRTIWQCTDTGSVDGIng----nVTIELAF 294 Clostridium bolteae ATCC BAA-613
YP_001691680 708 nqfe-rerlkdYDIWIAHWhvtnpn------cytpdYGMWQFTNKSKIKGVpdtgeggVDMNYSY 765 Finegoldia magna ATCC 29328
ZP_02074340  308 ndvnsnaiaknYQIWLAQYpgwdsatgsihasfdgkYSYWQYTSSGSVDGIag----rVDMNFRY 368 Clostridium sp. L2-50
ZP_02444063  145 ywvd-dkqleaYDKWVAQYaekctyt---gsygmwqHHGDARGFVGRVDGIsv----pVDINACY 201 Anaerotruncus colihominis DSM ...
ZP_02207438  236 ddmnisninnkYPVWSALYsdsdtd------slkakHSYWQYSEDGTVAGIgr----aTDMNFRY 290 Coprococcus eutactus ATCC 27759

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap