Conserved Protein Domain Family
GH25_muramidase_1

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cd06413: GH25_muramidase_1 
Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.
Statistics
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PSSM-Id: 119375
View PSSM: cd06413
Aligned: 19 rows
Threshold Bit Score: 271.075
Threshold Setting Gi: 169836239
Created: 30-Aug-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active site
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #                        #                            # #                 
tigr:BR1447  68 YPIHGTDVSKYQSDVDWsav-rasGISFAFIKATEGGDRVDERFNEHWSGTREARLPRGAYHFYYFCRPAIEQARWYIQN 146 Brucella suis 1330
YP_045016    54 YTVRGFDVSHHQGNIDWaki-spqKFQFVYLKATEGGDFQDPKFQENWLKAREYHFHVGAYHFYRLCRDGKTQAENFIAT 132 Acinetobacter sp...
AAP78107     25 YPIKGVDVSAHQGQIEWkil-keqGISFAFIKATEGSKWVDKRFAYNFENAHNQGLFVGAYHFFSFDSSGLTQAENFIRN 103 Helicobacter hep...
YP_020135    39 YEIKGVDVASYQGDIDWrel-ekqNMKFAFIKATEGSAFVDKYFSKNWTNANKTSMRVGAYHFFSFDSKGETQAEQFIRN 117 Bacillus anthrac...
NP_108000    18 YPVRGIDVSHHQGQIDWrrv-aadDVAFAIIKATEGGDHVDRAFATNLREARAAGIAVGAYHFFTFCRPGADQAKNFISV 96  Mesorhizobium lo...
YP_001038    44 YPIRGIDVSNHQGKIDWtlv-pksEISFVYIKATEGRDFKDKSFHLNWKKAKANGFFVGAYHFFTLCKSGKEQAENFIST 122 Leptospira inter...
YP_767148    40 YPIQGIDVSHHQGDIDWkvvasqpNVRFAFMKATEGGDHRDSKFADNWQRAGDAGVVRGAYHFFTFCRPGKDQAQNVLAT 119 Rhizobium legumi...
ZP_01548507  39 YTIRGIDISHHQGDIDWaqv-aadDVAFVYMKATEGGDFKDRAFARNWAGAGGAGLARGAYHFFSLCKSGREQAENFLSV 117 Stappia aggregat...
YP_759175    37 PGAEGLDLSHHNGAVDWprl-staGLSFVYLKATEGEGHVDTRFQENWLGAWRHHWQAGAYHFYLLCQDGRRQADNFIRQ 115 Hyphomonas neptu...
ZP_02086140  71 YPVRGVDVSHYQGEIDWkvl-grqDIDFAYIKATEGSSHVDEKFYQNWSESALSGLAVGAYHFFSFDSSGKDQLAHFIQC 149 Clostridium bolt...
Feature 1                     # #                                      #                      # 
tigr:BR1447 147 VPreq--saLPPVLDMEWnphsptcklrpnaavvRREMRTFLQAVEKHYGKRPVIYTTVDFFDDNdlrq---lseyPFWL 221 Brucella suis 1330
YP_045016   133 VPkki--daLPPVIDLEYdancint---ytkeqlLEQIKVTHDLLKAHYGKQPIFYVSKNFYHIVlmgs---fqnaPLWI 204 Acinetobacter sp...
AAP78107    104 VQndkspkrLPPVIDIEFygtkasn--ppsaqsvYKELDKLLLHLEQYYGVKPIIYTTPSFYDMYlrgr---ykdnPLWI 178 Helicobacter hep...
YP_020135   118 VPkyk--qaLPPVIDVEFyankkdn--ppkredvTKELSVMIEMLEKHYGKKVILYATQEAYDLYikda---ypqcDIWI 190 Bacillus anthrac...
NP_108000    97 VPhdq--plLPPVVDVEFggncpqr---pspeqlNAELQAFLGPVEAAFGKTAIVYLTDEAEAAYarqi----aarPLWL 167 Mesorhizobium lo...
YP_001038   123 VPkei--dsLPPVVDLEFlgncker---ssmkdvSNEIQEFLNRVDSHYGKKTILYLTYEFIDRYigpn---fqdhPIWI 194 Leptospira inter...
YP_767148   120 VPkeq--gtLPIAVDLEFvgncnki---ptleemVAEVNAFFTELKGTFPEKPIFYVTQEFFDQYlkgnesrfpdhYLWL 194 Rhizobium legumi...
ZP_01548507 118 LPqds--dmLAPVVDLEYtgncarr---ppaeevLQEISDFAALVEQGRGKQVILYVPENFYLDYlkgr---glnrRLWT 189 Stappia aggregat...
YP_759175   116 VEvrs--gaLPPAVDLEHahncapq---nsrgetLADLKVFLAALEAEYGAVPVIYTTPAFHAEWlageg--fdahPLWV 188 Hyphomonas neptu...
ZP_02086140 150 LPdre--gmLPPAVDVEFygdkaan--ppnpadvEQELGALLEGLEAQYGIVPVIYATEESWNLYirgr---fdryPLWI 222 Clostridium bolt...
Feature 1                                  #                 #      
tigr:BR1447 222 RSvaghpde--------kygphpWTFWQYTGTGSIPGi---RGDADINTFAG 262 Brucella suis 1330
YP_045016   205 RDydgkpe---------lkddrqWLFWQYTSKSSIKGi---EKPVDLNVYAG 244 Acinetobacter sp. ADP1
AAP78107    179 RSvffaphslwarlfnvyfdknsWIFWQYNPKGVLKGysgaEKYIDLNVFNG 230 Helicobacter hepaticus ATCC 51449
YP_020135   191 RSvltkps---------lsderkWTFWQYTNRGKLSGyngkEKYIDLNVFYG 233 Bacillus anthracis str. 'Ames Ancestor'
NP_108000   168 RSllmep------------drhdWVYWQYHNQGRVDGi---QGNVDLNVLQG 204 Mesorhizobium loti MAFF303099
YP_001038   195 RDlfkhpn---------tfsnqrWILWQYKSRGSLPGi---SGPVDMNVLNG 234 Leptospira interrogans serovar Copenhageni s...
YP_767148   195 RSvfrepr---------qeecshWSIWQFADNGTLDGi---QGPVDLNALCP 234 Rhizobium leguminosarum bv. viciae 3841
ZP_01548507 190 QSiwhsp-----------gyvsdWTLWQYHDRGTIKGv---SGDVDLNVLHP 227 Stappia aggregata IAM 12614
YP_759175   189 RSlegp-------------prlpYAIWQYSMKGRVPGv---TGNVDLNRAAE 224 Hyphomonas neptunium ATCC 15444
ZP_02086140 223 RNvktkpr----------tegepWLLWQYTNRQRLGGyegeETFIDMNVYCG 264 Clostridium bolteae ATCC BAA-613

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