1JFX


Conserved Protein Domain Family
GH25_CH-type

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cd06412: GH25_CH-type 
Click on image for an interactive view with Cn3D
CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme (acetylmuramidase) and diacetylmuramidase activity. The first member of this family to be described was a muramidase from the fungus Chalaropsis. However, a majority of the CH-type lysozymes are found in bacteriophages and Gram-positive bacteria such as Streptomyces and Clostridium. CH-type lysozymes have a single glycosyl hydrolase family 25 (GH25) domain with an unusual beta/alpha-barrel fold in which the last strand of the barrel is antiparallel to strands beta7 and beta1. Most CH-type lysozymes appear to lack the cell wall-binding domain found in other GH25 muramidases.
Statistics
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PSSM-Id: 119374
View PSSM: cd06412
Aligned: 16 rows
Threshold Bit Score: 293.844
Threshold Setting Gi: 40739237
Created: 30-Aug-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            #                       #  #                            # #                 
1JFX_A         5 VQGIDVSHWQGSINWSSVKSAGMSFAYIKATEGTNYKDDRFSANYTNA---YNAGIIRGAYHFARPnassGTAQADYFAS 81  Streptomyces co...
P00721         2 VQGFDISSYQPSVNFAGAYSAGARFVIIKATEGTSYTNPSFSSQYNGAttaTGNYFIRGGYHFAHPgettGAAQADYFIA 81  Chalara sp.
EAA63764      17 VQGFDISHYQETVDYQGAYDSGARFVMIKATEGTSYTDPKFSTHYSGA---TSAGLIRGGYHFAQPgsssGADQASYFIE 93  Aspergillus nid...
EAK83625      31 IPGFDVSGYQPNANMNGAYANGARFVYIKATEGTTFKSSSFSSQYNAA---TNAGLIRGAYHFARPdsssGATQARFFLN 107 Ustilago maydis...
CAC04501      70 TEGVDVSSHQGNVAWSTLWNSGVKWAYAKATEGTYYTNPYFAQQYNGS---YNVGMIRGAYHFATPdttsGATQANYFVD 146 Streptomyces co...
YP_056352     81 PEGMDVSSHDGNVDWPAKVSSGMSFAWVKATEGTSYQNPFYASQYNGS---QSAGLIRGAYHFALPsnssGQAQATYFSD 157 Propionibacteri...
YP_832153    155 VKGLDVSAYQSTVDWLQQWNMGARFAYVKASEGNYYTNPSYSSQYNGS---RNVGMIRGAYHFAIPnwssGADQARYFVQ 231 Arthrobacter sp...
AAC45578      34 ALGIDVSNHNGEVDFAKVGADGRDFAFVLATDGESFTSDLFDSQYSGA---GEAGLYRAGYHFARPdg-sATKQADRFLK 109 Saccharopolyspo...
YP_001107508 157 AEGIDVSNHNGSIDWRKVAADGKQFTFVLATDGTSFTNPRYSEQYHGA---KEAGLIAGAYHFARPdk-sAEAQADRLLA 232 Saccharopolyspo...
YP_001105960  75 VAGMDVSGHQGVVDWRAAWDAGARFAYVKASEGVGFRNKHFPQQYDGS---RGVGMVRGAYHFALPdrssGAEQAHFFVD 151 Saccharopolyspo...
Feature 1                        # #                                               #             
1JFX_A        82 NgggwsrDNRTLPGVLDIEhnps----------gamCYGLSTTQMRTWINDFHARYKARTTrDVVIYTTASWWNTCTGSW 151 Streptomyces co...
P00721        82 HgggwsgDGITLPGMLDLEsegs----------npaCWGLSAASMVAWIKAFSDRYHAVTGrYPMLYTNPSWWSSCTGNS 151 Chalara sp.
EAA63764      94 HgggwsgDGQTLPGMLDLEa---------------gCYGLSTSAMSSWIKDFGETYKAATGrYPMIYTTTSWWQECTGND 158 Aspergillus nid...
EAK83625     108 NgggwsaDGRTLPGALDLEsssg----------vatCYGLSKSQLVSWIQDFGNTYHASTGrYPTLYCSSGWWNQCVASS 177 Ustilago maydis...
CAC04501     147 HgggwsrDGKTLPGALDIEwnpy----------gatCYGKSQSGMVSWIRDFLNTYKARTGrDAVIYTATSWWTQCTGNY 216 Streptomyces co...
YP_056352    158 HgggwseDGYTLPGVVDLEynpy---------genaCYGLSQTAMASWIRDFVSTYQERWGrAPMIYTSTSWWNMCVGSA 228 Propionibacteri...
YP_832153    232 NgggwtpDGYTLPPVLDFEfnpyegrtingfyfgntCYGMSPAQLTSWVRDFGNTMLAMTGrLPMIYTNTSWWKLCTADA 311 Arthrobacter sp...
AAC45578     110 Tvgs-tnDGRTMPPVLDMEanpn----------gatCYGLDDAQMEEWIKSFVGRVKEKTGrEAVIYTSPSFWKECTGNS 178 Saccharopolyspo...
YP_001107508 233 Tady-qpDGRSLPPVLDLEvdpk----------gggCYGLSVQEMHQWTDTFNRKIKDATGkDPIIYANPSFWNQCMGGT 301 Saccharopolyspo...
YP_001105960 152 NgggwvpDGHTLPGALDVEhnpy----------ggaCYGLPPEGMSRWIAEFSDTYRARTGrFPAIYTTTRWWQQCTGGN 221 Saccharopolyspo...
Feature 1                  #                         #              #           
1JFX_A       152 NGMaa-kSPFWVAHWgvs----aptVPSGFPTWTFWQYSATGrvggvsgdVDRNKFNGSAARL 209 Streptomyces coelicolor
P00721       152 NAFvn-tNPLVLANRyasa---pgtIPGGWPYQTIWQNSDAYay-----gGSNNFINGSIDNL 205 Chalara sp.
EAA63764     159 SGFg--eYPLVVARWgss----vgtLPASWSTHSFWQNADTYef-----gGDSEVWNGSEDSL 210 Aspergillus nidulans FGSC A4
EAK83625     178 AFAs--nYALWVANYgvs----spkIPTGFNYYTFWQYSDNGpy-----pGDSDTFNGSLDGL 229 Ustilago maydis 521
CAC04501     217 GGFaa-sNPLWIARYast----vgtLPAGWGYYTMWQYTSSGpt-----vGDHNKFNGALDRV 269 Streptomyces coelicolor A3(2)
YP_056352    229 ASDitavAPLWIARYsst----vgeLPSGWDAWTMWQYSDTG--------YDHDRMAGTREDL 279 Propionibacterium acnes KPA171202
YP_832153    312 AGFg--dYPLWVAAYpssatndagpVPSSWDTYSMWQYSSTGpy-----aGDSNVWNGDYASL 367 Arthrobacter sp. FB24
AAC45578     179 EAFt--tNPLWTAEWdvd----kpsKVGGWPAHTFWQYSNSGkvdgvdgaVDVNRFNGGTAEL 235 Saccharopolyspora erythraea NRRL...
YP_001107508 302 ADYg--dHPLWLASYgvs----npkVPAGFDNWDFWQYTDSGkvagiskpTDLNQFQGGIERL 358 Saccharopolyspora erythraea NRRL...
YP_001105960 222 PSFga-nNPLWLARYape----pgaLPAGWRFHTIWQFADRGvf-----pGDQNTFNGGPEQL 274 Saccharopolyspora erythraea NRRL...

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