Conserved Protein Domain Family
PB1_UP2

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cd06410: PB1_UP2 
Uncharacterized protein 2. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in many critical cell processes such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions.
Statistics
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PSSM-Id: 99731
View PSSM: cd06410
Aligned: 27 rows
Threshold Bit Score: 103.454
Threshold Setting Gi: 147810341
Created: 28-Feb-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ABK24411      35 LCRYGGrilprpGDGKLRYAGGNTRVVAASRsiGFADLIAKMSKVFGSsa---vlLKCQLPSEDLd--aLVSVKSDEDLE 109 Sitka spruce
CAN80111       9 LCNFGGef--trQLGKLSYMGGKTRLVLVDRsvSFDELRSKLSQLTCAcpf-sieIKYQLPDESLes-rLVSVECEDDVV 84  wine grape
AAT76996       4 LCSHGGrlvpcgPGGGLRYVGGETRALAVPRgaPFRELTARLAEKAGAggdavtaVRYRLADGGLdedlLVSVTSDEELA 83  Japanese rice
ABK25040      24 LCSYGGkilprpSDGQLRYVGGETRLVTVDRsiTFRDFMKKLEDIFETmn---viIKYQLPTLDLd--iLISVICDEDLQ 98  Sitka spruce
AAL58900       9 ICQSGGefv-tiKDGSLSYSGGDAFAIDIDQntSMTDFKSELAENFGFgle-amtLKYFLPGNKKt---LITISKDKDFI 83  thale cress
Q9M9L2         9 ICMSGGefq-teKGGSLSYKGGDAHAIDVDEqmKFIDFISEIGEMFNCdvr-tvsLKYFLPDNKKt---LISISNDKDLK 83  thale cress
EAZ25023      44 MVSYGGriqprpHDHQLSYVNGETKILSLERplRFADFAARLAGLAGSpgd--fcVKYQLPGEDLd--aLVSVTNDEDLE 119 Japanese rice
EAZ34370      46 LCSFGGrimprpSDGALKYIGGETRVLAVPRsiPFSDLKKKVEEMFRTev---aaIKYQLVAEDLd--vLVSVTCDEDLT 120 Japanese rice
NP_001050317  50 ICNFGGrflprpSDGQLRYVGGERHLIKISRdiSWKELICKTSKLIRRah----mIKYHLPGEPMn--mLISITCDDDLR 123 Japanese rice
NP_001046162   9 VLQVGGefk-tdDDGQMSYSGGEAHAMHVKSdwTFKTFKHEISSTLNNlkldsyvFKYFLPRNNKt---LISISNDKDLK 84  Japanese rice
ABK24411     110 NMLEEYdrvg-------------areGLSKVRAFLF 132 Sitka spruce
CAN80111      85 AMMSEFe-------------------ASQRIQVYIF 101 wine grape
AAT76996      84 HMRDEYdrlr-------------atrPSASFRVFVS 106 Japanese rice
ABK25040      99 NMMEEYdryds----------hkesgPCPRVKAFLF 124 Sitka spruce
AAL58900      84 RMVNFSs-------------------DAGTVEIFVI 100 thale cress
Q9M9L2        84 RMIKFHe-------------------NSNTADVYLL 100 thale cress
EAZ25023     120 HLVLEYdrlhllrpapgsgggssrggSTPRLRVFLF 155 Japanese rice
EAZ34370     121 HMLDEYdrfea----------krspsASPRFRVYVF 146 Japanese rice
NP_001050317 124 NMIDECivl---------------erTKVLLTVYLF 144 Japanese rice
NP_001046162  85 RMVEFHa-------------------ESETTYIYVM 101 Japanese rice
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