Conserved Protein Domain Family
PB1_NLP

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cd06407: PB1_NLP 
A PB1 domain is present in NIN like proteins (NLP), a key enzyme in a process of establishment of symbiosis betweeen legumes and nitrogen fixing bacteria (Rhizobium). The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in many critical cell processes like osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants.
Statistics
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PSSM-Id: 99728
View PSSM: cd06407
Aligned: 10 rows
Threshold Bit Score: 112.802
Threshold Setting Gi: 125580730
Created: 27-Feb-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAE30324     817 HRVKVTYGDEKTRFRMpk-swSYEHLLQEIARRFNVsdm--skFDVKYLDDDLEWVLLTCDADLEECIDVClss--esST 891  Lotus japonicus
NP_001048860 845 LKIKAIYGEERCIFRLqp-swGFQRLKEEIVKRFGIsqd--thVDLKYLDDESEWVLLTCDADLLECIDVYkss--snQT 919  Japanese rice
Q9SVF1       674 MKVKAMFGDSMLRMSLlp-hsRLTDLRREIAKRFGMddvlrsnFSLKYLDDDQEWVLLTCDADLEECIQVYkss-slkET 751  thale cress
EAZ45577     798 MRVKVTFGSEKVRFRLkp-ecDFQELKQEISKRLSIadm--nsLIVKYLDDDSEWVLMTCDADLHECFHVYkla--diQT 872  Japanese rice
Q9S7B1       781 FRVKATFADEKIRFSLqp-iwGFSDLQLEIARRFNLndv--tnILLKYLDDDGEWVVLACDGDLEECKDIHrss--qsRT 855  Lotus japonicus
Q9SGW2       748 VSIKATYREDIIRFKIspesvSITELKQQVAKRLKLet---aaFELKYLDDDREWVSVSCDADLSECLDTSaa---kaNT 821  thale cress
XP_001770664 698 VTVKATFGADTVRFKLlv-ksSYLELRTEISGRLKVdd---qgFDLKYLDDEEEWMLITCDADVKECIEVArtl--grHT 771  Physcomitrella...
Q9LE38       745 LRIKVSYGEEKIRLRMrn-srRLRDLLWEIGKRFSIedm--srYDLKYLDEDNEWVLLTCDEDVEECVDVCrtt--psHT 819  thale cress
O22864       848 LIVKASYREDTVRFKFep-svGCPQLYKEVGKRFKLqd---gsFQLKYLDDEEEWVMLVTDSDLQECLEILhgm--gkHS 921  thale cress
EAZ21661     551 VTIKASHRGDIIRFRVpc-saGVAAVKAVVAKRLSLda---gaFDVKYLDDDHEWVLLSCDADFQECLDVVpalpsmsVT 626  Japanese rice
CAE30324     892 IKLCIQA 898  Lotus japonicus
NP_001048860 920 VRILVNP 926  Japanese rice
Q9SVF1       752 IRILVHH 758  thale cress
EAZ45577     873 IKISVHL 879  Japanese rice
Q9S7B1       856 IRLSLFQ 862  Lotus japonicus
Q9SGW2       822 LRLSVHD 828  thale cress
XP_001770664 772 VKLMVRE 778  Physcomitrella patens subsp. patens
Q9LE38       820 IKLLLQA 826  thale cress
O22864       922 VKFLVRD 928  thale cress
EAZ21661     627 ARSGSGA 633  Japanese rice
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