1WMH


Conserved Protein Domain Family
PB1_aPKC

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cd06404: PB1_aPKC 
Click on image for an interactive view with Cn3D
PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific protein-protein interaction which play roles in many critical cell processes. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants. The aPKC protein contains a type I/II PB1 domain.
Statistics
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PSSM-Id: 99725
View PSSM: cd06404
Aligned: 12 rows
Threshold Bit Score: 133.625
Threshold Setting Gi: 51701751
Created: 27-Feb-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
PB1 interaction
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:PB1 interaction surface [polypeptide binding site]
Evidence:
  • Structure:1WMH; Human PKCiota and Par6alpha form an asymmetric heterodimer
    View structure with Cn3D
  • Comment:Par6 contains a type II PB1 domain and aPKC contains a type I/II PB1 domain

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                      # # #        #                    
1WMH_A         7 VRVKAYYrGDIMITHFepsISFEGLCNEVRDMCSFdneqlFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDs-ELLIH 85  human
NP_001084068  19 VRVKAYFkGDIMITHFepsITFDGLCNEVRDMCSFendqpFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDs-ELLIH 97  African clawed ...
Q90XF2        19 VRVKAYYrGDIMITHFepsISYEGLCNEVRDMCSMdndqlFTMKWIDEEGDPCTVSSQLELEEALRLYELNKDs-ELIIH 97  zebrafish
NP_001036545  31 ITVKTAYnGQIIITTInknISYEELCYEIRNICRFpldqpFTIKWVDEENDPCTISTKMELDEAIRLYEMNFDs-QLVIH 109 fruit fly
BAF99000      15 IPIKAAFnGSILCIRIdpnVTLEDFLQDMRGICNFpekqnFTVKWLDEDGDPCTISSQEELEEAIRLYELNKDs-NINIH 93  Hemicentrotus p...
Q05513        16 VRLKAHYgGDIFITSVdaaTTFEELCEEVRDMCRLhqqhpLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDe-GLIIH 94  human
XP_417561     30 FRIRAEFgRDILITNLdayISYDELCDEVREMCNLqqeqpITLKWIDDEGDPCTISSQMELEEAFRLYCQNREe-GLIIH 108 chicken
XP_001089400  26 VRVKAYYrGDIMITHFepsISFEGLCNEVRDMCSFdneqlFTMKWIDEEGDSTFLDSTYHVVFAFKLYPLNNSslSLLLH 105 rhesus monkey
XP_001637001   8 IAVRAAYnGDIMCLSMdphISLDTFTEDMKDIFKFrkeqtFTLKWLDEEGDPCTISSQEELNEAIRLYEINRDs-ELVVH 86  starlet sea ane...
NP_001036923  16 VRVKTVYnGDVMITYInhnITFEEFTHEMVATCRFapdqvFTMKWVDEEGDPCTISTQLELDESLRLYELNRDs-ELTVH 94  domestic silkworm
Q19266        13 IKLKTRFqGQVVVLYArppLILDDFFALLKDACKQhkkqdITVKWIDEDGDPISIDSQMELDEAVRCLNSSQEa-ELNIH 91  Caenorhabditis ...
AAX28346       9 LQIKYIHnSIAMVTSCplsANLQAIDQQVRELCRFssdqpFTLKWIDEEQDPIVISSDMELKEAFRLHELNKEw-QLTVL 87  Schistosoma jap...
Feature 1            
1WMH_A        86 VFPC 89  human
NP_001084068  98 VFPC 101 African clawed frog
Q90XF2        98 VFPC 101 zebrafish
NP_001036545 110 VFPN 113 fruit fly
BAF99000      94 VFPT 97  Hemicentrotus pulcherrimus
Q05513        95 VFPS 98  human
XP_417561    109 VFPS 112 chicken
XP_001089400 106 VFPC 109 rhesus monkey
XP_001637001  87 LFLG 90  starlet sea anemone
NP_001036923  95 VFPN 98  domestic silkworm
Q19266        92 VFVG 95  Caenorhabditis elegans
AAX28346      88 VFDG 91  Schistosoma japonicum

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