Conserved Protein Domain Family
PB1_TFG

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cd06401: PB1_TFG 
The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. The PB1 domains of TFG represent a type I/II PB1 domain. The physiological function of TFG remains unknown.
Statistics
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PSSM-Id: 99722
View PSSM: cd06401
Aligned: 9 rows
Threshold Bit Score: 105.673
Threshold Setting Gi: 66826367
Created: 27-Feb-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAH65630      11 LIIKAQLGDDIRRIPIHNEDiTYDELLLMMQRVFRGqlqssdeVTIKYKDEDDDLITIFD--SSDLSFAIQCsr---iLK 85  zebrafish
Q9DGF6        11 LIIKAQLGEDIRRIPIHNEDiTYDELVLMMQRVFRGklltndeVTIKYKDEDGDLITIFD--SSDLSFAIQCsr---iLK 85  African clawed ...
XP_416608     11 LIIKAQLGEDIRRIPIHNEDiTYDELVLMMQRVFRGkllsndeVTIKYKDEDGDLITIFD--SSDLSFAIQCsr---iLK 85  chicken
Q92734        11 LIVKAQLGEDIRRIPIHNEDiTYDELVLMMQRVFRGkllsndeVTIKYKDEDGDLITIFD--SSDLSFAIQCsr---iLK 85  human
XP_799290     17 LIIKAQLGDDIRRIPIHNEDiTYDELVLMMQRVYRGklnpsdeVVIKYKDEDGDLITIFD--STDLSFAIQCsr---iLK 91  purple urchin
XP_974473     14 LIIKVQLGDDIRRIPIHNEAiTYDELLLMMQRVFKGklfasddITIKYKDEDGDLITIFD--SSDLSFAIQCsr---iLK 88  red flour beetle
XP_001634096   7 LIIKAQLGDDIRRIPIHNEDlTYDELLLMMQRVFRGklnssddVLIKYKDEDGDLVTIFD--SSDLSFAKSMsr---iLR 81  starlet sea ane...
XP_646538      4 LILKIQHNDDTRRVSMERDP-TFLELRKMTVTFFKIn-----sFLIKYFDEDKDLITITSdnDLKEAFSIATts---pRT 74  Dictyostelium d...
AAS21370       2 VILKTEFKGDRRNIPLANEQlTFDDLLLMLCRIYSAdig--ddDLVKYLDSENDWITMND--SNDLSFAIQLaeddgrKF 77  Oikopleura dioica
AAH65630      86 LTLFVN 91  zebrafish
Q9DGF6        86 LTLFVN 91  African clawed frog
XP_416608     86 LTLFVN 91  chicken
Q92734        86 LTLFVN 91  human
XP_799290     92 ITLFVN 97  purple urchin
XP_974473     89 LQILPN 94  red flour beetle
XP_001634096  82 LTLFGK 87  starlet sea anemone
XP_646538     75 VRLFVS 80  Dictyostelium discoideum AX4
AAS21370      78 LKIKVG 83  Oikopleura dioica
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