2DYB,1OEY


Conserved Protein Domain Family
PB1_P40

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cd06399: PB1_P40 
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The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in many critical cell processes , such as osteoclastogenesis, angiogenesis, early cardiovascular development and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domain, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. The PB1 domain of p40 represents a type I PB1 domain which interacts with the PB1 domain of oxidase activator p67 which belong to type II PB1 domain. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants.
Statistics
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PSSM-Id: 99721
View PSSM: cd06399
Aligned: 4 rows
Threshold Bit Score: 157.343
Threshold Setting Gi: 34810995
Created: 27-Feb-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
PB1 interactionhydrophobic
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:PB1 interaction site [polypeptide binding site]
Evidence:
  • Structure:1OEY; Human NADPH oxidase subunits p40 and p67 form a heterodimer
    View structure with Cn3D
  • Comment:A canonical PB1-PB1 interaction between p40 and p67

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                           # # #        #               
2DYB_A       240 NWLRCYYyEDTISTIKDIaVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSDEDVALMVRQarglp--- 316 human
1OEY_J         6 NWLRVYYyEDTISTIKDIaVEEDLSSTPLLKDLLELTRREFQREDIALNYRDAEGDLVRLLSDEDVALXVRQarglp--- 82  human
NP_001034361 238 NKIRCYYyDETVSTIRDIsVEENLSSIPLFKDLMELIKQEFDQHDIVLNYRDLDGDLIRLLSDQDVELMVSQsrkrs--- 314 chicken
NP_001076354 250 SCLHCYFlQPEGIETRDIcVQEDLSIQPSYEDLLSRMRDVFHVDDIALNYRDAEGDLIRILDDEDVVLMVQEskrmeskv 329 zebrafish
Feature 1                        
2DYB_A       317 -sqkrlFPWKLHITQK 331 human
1OEY_J        83 -sqkrlFPWKLHITQK 97  human
NP_001034361 315 -sekhfFPWKLHITHK 329 chicken
NP_001076354 330 krpviqFPWELLVTHA 345 zebrafish

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