2BKF


Conserved Protein Domain Family
PB1_NBR1

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cd06396: PB1_NBR1 
Click on image for an interactive view with Cn3D
The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domain, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. The NBR1 protein contains a type I PB1 domain.
Statistics
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PSSM-Id: 99718
View PSSM: cd06396
Aligned: 5 rows
Threshold Bit Score: 124.188
Threshold Setting Gi: 156388111
Created: 27-Feb-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
PB1 interaction
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:PB1 interaction site [polypeptide binding site]
Evidence:
  • Comment: NBR1 contains a type I PB1 domain with an acidic amino acid OPCA motif

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                       # # #        #                    
2BKF_A          7 VTLNVTFknEIQSFLVsdpentTWADIEAMVKVSFDLn-tIQIKYLDEENEEVSINSQGEYEEALKMAvkqgnQLQMQVH 85   human
XP_418128       5 VNLRVSYrgETQSFLVsdtahtTWADVEAMVKVSFDLd-dIQIKYIDEDNDEVSVNSKEEYEEALKIAvkqgnQLQMNVY 83   chicken
AAI41800       34 INLKVTFrgNAKSFLLsgsetkSWESMEAMVKRSFGLc-nLQLTYFDEENEEVSVNSQLEYEEALKSAarqgnRLQMNVY 112  zebrafish
XP_001634545    5 VKVKATYnnISRRFEIps--cvEWSSFHALLQDYFGFeesCSTKYVDDESELVLLNSQAELDEAIRLIqrnskLLRIFVE 82   starlet sea a...
NP_001079967    5 VNLCVSCngESQNFLVsdsentTWADVETMVLVSYDLn-dIQIKYMDEDNEEVSVNSQGENEEALKSAvkqggLLRMNVY 83   African clawe...
Feature 1           
2BKF_A         86 EG 87   human
XP_418128      84 EE 85   chicken
AAI41800      113 ET 114  zebrafish
XP_001634545   83 DH 84   starlet sea anemone
NP_001079967   84 EK 85   African clawed frog

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